{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,5,14]],"date-time":"2025-05-14T02:42:21Z","timestamp":1747190541666,"version":"3.40.5"},"reference-count":56,"publisher":"Wiley","license":[{"start":{"date-parts":[[2021,6,3]],"date-time":"2021-06-03T00:00:00Z","timestamp":1622678400000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100000038","name":"Natural Resources and Engineering Research Council of Canada","doi-asserted-by":"crossref","award":["RGPIN-2019-04208"],"award-info":[{"award-number":["RGPIN-2019-04208"]}],"id":[{"id":"10.13039\/501100000038","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Autism Research and Treatment"],"published-print":{"date-parts":[[2021,6,3]]},"abstract":"<jats:p>Mutations affecting the synaptic-scaffold gene SHANK3 represent the most common genetic causes of autism with intellectual disability, accounting for about 1-2% of cases. Rare variants of this gene have also been associated with schizophrenia, and its deletion results in the autistic condition known as Phelan\u2013McDermid syndrome. Despite the importance of SHANK3 as a paradigmatic gene mediating neurodevelopmental disorders, its psychological effects in nonclinical populations have yet to be studied. We genotyped the nonsynonymous, functional SHANK3 SNP rs9616915 in a large population of typical individuals scored for autism spectrum traits (the Autism Quotient, AQ) and schizotypy spectrum traits (the Schizotypal Personality Questionnaire, SPQ-BR). Males, but not females, showed significant genotypic effects for the SPQ-BR subscale associated with speech and language: Odd Speech. These findings, in conjunction with animal model studies showing vocalization and auditory effects of SHANK3 mutations, and studies indicating severe language alterations and speech-associated white matter tract abnormalities in Phelan\u2013McDermid syndrome, suggest that SHANK3 differentially affects the development and expression of human language and speech. Imaging genetic and speech-language studies of typical individuals carrying different genotypes of rs9616915 should provide novel insights into the neurological and psychological bases of speech and language alterations among individuals with SHANK3 mutations and Phelan\u2013McDermid syndrome.<\/jats:p>","DOI":"10.1155\/2021\/6634584","type":"journal-article","created":{"date-parts":[[2021,6,4]],"date-time":"2021-06-04T19:35:46Z","timestamp":1622835346000},"page":"1-7","source":"Crossref","is-referenced-by-count":1,"title":["SHANK3 Genotype Mediates Speech and Language Phenotypes in a Nonclinical Population"],"prefix":"10.1155","volume":"2021","author":[{"given":"Christina","family":"Manning","sequence":"first","affiliation":[{"name":"Department of Biological Sciences, Simon Fraser University, Burnaby, BC, Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Peter L.","family":"Hurd","sequence":"additional","affiliation":[{"name":"Department of Psychology and Centre for Neuroscience, University of Alberta, Edmonton, Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Silven","family":"Read","sequence":"additional","affiliation":[{"name":"Department of Biological Sciences, Simon Fraser University, Burnaby, BC, Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0362-392X","authenticated-orcid":true,"given":"Bernard","family":"Crespi","sequence":"additional","affiliation":[{"name":"Department of Biological Sciences, Simon Fraser University, Burnaby, BC, Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","reference":[{"key":"1","doi-asserted-by":"publisher","DOI":"10.1038\/nrn3992"},{"key":"2","doi-asserted-by":"publisher","DOI":"10.1038\/nrn.2016.183"},{"key":"3","doi-asserted-by":"publisher","DOI":"10.1086\/522590"},{"key":"4","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pgen.1004580"},{"key":"5","doi-asserted-by":"publisher","DOI":"10.1007\/978-3-540-72843-6_15"},{"key":"6","doi-asserted-by":"publisher","DOI":"10.1007\/s00401-017-1736-4"},{"key":"7","doi-asserted-by":"publisher","DOI":"10.1038\/s41431-020-00761-1"},{"key":"8","doi-asserted-by":"publisher","DOI":"10.1186\/2040-2392-4-18"},{"key":"9","doi-asserted-by":"publisher","DOI":"10.1186\/s13229-018-0205-9"},{"key":"10","doi-asserted-by":"publisher","DOI":"10.1007\/s00439-014-1423-7"},{"key":"11","doi-asserted-by":"publisher","DOI":"10.1186\/s13229-019-0291-3"},{"key":"12","doi-asserted-by":"publisher","DOI":"10.1542\/peds.2019-1490"},{"key":"13","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0906080106"},{"key":"14","doi-asserted-by":"publisher","DOI":"10.1038\/nature12630"},{"key":"15","doi-asserted-by":"publisher","DOI":"10.1038\/ng1933"},{"key":"16","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0906232107"},{"key":"17","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0034739"},{"key":"18","doi-asserted-by":"publisher","DOI":"10.1038\/ejhg.2012.175"},{"key":"19","doi-asserted-by":"publisher","DOI":"10.1097\/ypg.0b013e328341e069"},{"key":"20","doi-asserted-by":"publisher","DOI":"10.1002\/ajmg.b.32528"},{"key":"21","doi-asserted-by":"publisher","DOI":"10.1007\/s11033-013-3005-5"},{"issue":"3","key":"22","first-page":"251","article-title":"The Association of SHANK3 Gene Polymorphism and Autism","volume":"73","author":"F. 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