{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T01:49:26Z","timestamp":1787017766241,"version":"build-2736575974"},"reference-count":62,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2021,3,11]],"date-time":"2021-03-11T00:00:00Z","timestamp":1615420800000},"content-version":"vor","delay-in-days":69,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100002767","name":"Department of Science and Technology of Hunan Province","doi-asserted-by":"publisher","award":["2017NK2180"],"award-info":[{"award-number":["2017NK2180"]}],"id":[{"id":"10.13039\/501100002767","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Oxidative Medicine and Cellular Longevity"],"published-print":{"date-parts":[[2021,1]]},"abstract":"<jats:p>\n                    Cigarette smoke\u2010 (CS\u2010) induced oxidative stress and inflammation in the lung are serious health problems. Primary and reprocessed tea products contain multiple antioxidants that have been reported to protect the lung against CS\u2010induced injury. However, the beneficial effects of\n                    <jats:italic>Eurotium cristatum<\/jats:italic>\n                    fermented loose dark tea (ECT) and\n                    <jats:italic>Eurotium cristatum<\/jats:italic>\n                    particle metabolites (ECP) on CS\u2010induced lung injury and its potential hepatic metabolic detoxification are still unclear. Therefore, sixty mice were randomly divided into six equal groups. CS\u2010exposed mice were prevented or treated with ECP or ECT infusions for 12 or 8 weeks to determine the antioxidative stress, anti\u2010inflammatory and potential metabolic detoxification of ECT and ECP. Thirty\u2010six mice were randomly divided into six equal groups to observe the effects on hepatic metabolic detoxification by replacing daily drinking water with ECT. Results showed that CS significantly decreased the activities of glutathione peroxidase (GSH\u2010Px) and superoxide dismutase (SOD) and upregulated the expressions of malondialdehyde (MDA), tumor necrosis factor alpha (TNF\u2010\n                    <jats:italic>\u03b1<\/jats:italic>\n                    ), interleukin\u20106 (IL\u20106), IL\u20108, and IL\u20101\n                    <jats:italic>\u03b2<\/jats:italic>\n                    in serum. These adverse effects were modulated by ECP and ECT. In addition, ECT upregulated the mRNA expression of pregnane X receptor (\n                    <jats:italic>PXR<\/jats:italic>\n                    ) and cytochrome P450 (\n                    <jats:italic>CYP450<\/jats:italic>\n                    ) in the liver on daily free drinking ECT mice group. Western blot analysis further revealed that in CS\u2010exposed mice, ECP and ECT significantly decreased the phosphorylation of mitogen\u2010activated protein kinase (MAPK) in the lung but upregulated the protein expressions of\n                    <jats:italic>PXR<\/jats:italic>\n                    and aryl hydrocarbon receptor (\n                    <jats:italic>AhR<\/jats:italic>\n                    ) in the liver. Overall, our findings demonstrated that ECT and ECP protected against lung injury induced by CS via MAPK pathway and enhanced hepatic metabolic detoxification via\n                    <jats:italic>PXR<\/jats:italic>\n                    and\n                    <jats:italic>AhR<\/jats:italic>\n                    pathways. Therefore, daily intake of ECT and ECP can potentially protect against CS\u2010induced oxidative and inflammatory injuries.\n                  <\/jats:p>","DOI":"10.1155\/2021\/6635080","type":"journal-article","created":{"date-parts":[[2021,3,11]],"date-time":"2021-03-11T12:35:09Z","timestamp":1615466109000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":22,"title":["<i>Eurotium cristatum<\/i>\n                    Fermented Loose Dark Tea Ameliorates Cigarette Smoke\u2010Induced Lung Injury by MAPK Pathway and Enhances Hepatic Metabolic Detoxification by\n                    <i>PXR<\/i>\n                    \/\n                    <i>AhR<\/i>\n                    Pathway in Mice"],"prefix":"10.1155","volume":"2021","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3157-689X","authenticated-orcid":false,"given":"Xiang-Xiang","family":"Huang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6818-1977","authenticated-orcid":false,"given":"Shuai","family":"Xu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0753-4465","authenticated-orcid":false,"given":"Li-Jun","family":"Yu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3418-5720","authenticated-orcid":false,"given":"Yu-Fei","family":"Zhou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1889-1553","authenticated-orcid":false,"given":"Ying","family":"Zhou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0000-4565","authenticated-orcid":false,"given":"Zhong-Hua","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2021,3,11]]},"reference":[{"key":"e_1_2_9_1_2","doi-asserted-by":"publisher","DOI":"10.1136\/tc.12.4.424"},{"key":"e_1_2_9_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.tiv.2013.11.004"},{"key":"e_1_2_9_3_2","doi-asserted-by":"publisher","DOI":"10.1111\/and.12926"},{"key":"e_1_2_9_4_2","doi-asserted-by":"publisher","DOI":"10.1042\/bsr20193667"},{"key":"e_1_2_9_5_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.freeradbiomed.2014.01.026"},{"key":"e_1_2_9_6_2","doi-asserted-by":"publisher","DOI":"10.7860\/JCDR\/2013\/4360.2832"},{"key":"e_1_2_9_7_2","doi-asserted-by":"publisher","DOI":"10.3748\/wjg.v12.i38.6098"},{"key":"e_1_2_9_8_2","doi-asserted-by":"publisher","DOI":"10.2165\/00003088-199936060-00004"},{"key":"e_1_2_9_9_2","doi-asserted-by":"publisher","DOI":"10.2133\/dmpk.DMPK-11-RG-094"},{"key":"e_1_2_9_10_2","doi-asserted-by":"publisher","DOI":"10.3390\/antiox8070215"},{"key":"e_1_2_9_11_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijbiomac.2018.04.184"},{"key":"e_1_2_9_12_2","doi-asserted-by":"publisher","DOI":"10.1002\/mnfr.201700485"},{"key":"e_1_2_9_13_2","doi-asserted-by":"publisher","DOI":"10.3390\/nu7075218"},{"key":"e_1_2_9_14_2","doi-asserted-by":"publisher","DOI":"10.1002\/fsn3.1331"},{"key":"e_1_2_9_15_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.lfs.2020.118260"},{"key":"e_1_2_9_16_2","doi-asserted-by":"publisher","DOI":"10.1183\/09031936.00012412"},{"key":"e_1_2_9_17_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00011-020-01333-1"},{"key":"e_1_2_9_18_2","doi-asserted-by":"publisher","DOI":"10.3109\/10715762.2012.692786"},{"key":"e_1_2_9_19_2","doi-asserted-by":"publisher","DOI":"10.1186\/1476-9255-4-3"},{"key":"e_1_2_9_20_2","doi-asserted-by":"publisher","DOI":"10.1111\/1750-3841.12831"},{"key":"e_1_2_9_21_2","doi-asserted-by":"publisher","DOI":"10.1089\/ars.2016.6895"},{"key":"e_1_2_9_22_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2016.05.011"},{"key":"e_1_2_9_23_2","doi-asserted-by":"publisher","DOI":"10.1016\/S1470-2045(02)00815-X"},{"key":"e_1_2_9_24_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.brainres.2015.09.018"},{"key":"e_1_2_9_25_2","doi-asserted-by":"publisher","DOI":"10.2147\/copd.s42414"},{"key":"e_1_2_9_26_2","doi-asserted-by":"publisher","DOI":"10.3390\/ijms161125942"},{"key":"e_1_2_9_27_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jnutbio.2016.05.005"},{"key":"e_1_2_9_28_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.fct.2014.04.043"},{"key":"e_1_2_9_29_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.lwt.2019.108629"},{"key":"e_1_2_9_30_2","doi-asserted-by":"publisher","DOI":"10.3390\/molecules191117839"},{"key":"e_1_2_9_31_2","doi-asserted-by":"publisher","DOI":"10.1039\/C9FO02921D"},{"key":"e_1_2_9_32_2","doi-asserted-by":"publisher","DOI":"10.1093\/cvr\/cvr032"},{"key":"e_1_2_9_33_2","doi-asserted-by":"publisher","DOI":"10.1183\/09031936.00158110"},{"key":"e_1_2_9_34_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.pupt.2013.03.002"},{"key":"e_1_2_9_35_2","doi-asserted-by":"publisher","DOI":"10.1002\/jbt.21586"},{"key":"e_1_2_9_36_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jep.2015.08.056"},{"key":"e_1_2_9_37_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejphar.2010.12.040"},{"key":"e_1_2_9_38_2","doi-asserted-by":"publisher","DOI":"10.1002\/cbf.3273"},{"key":"e_1_2_9_39_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.freeradbiomed.2015.06.021"},{"key":"e_1_2_9_40_2","doi-asserted-by":"publisher","DOI":"10.1007\/s11655-018-2577-2"},{"key":"e_1_2_9_41_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.cbi.2005.04.008"},{"key":"e_1_2_9_42_2","doi-asserted-by":"publisher","DOI":"10.1186\/s12931-017-0625-7"},{"key":"e_1_2_9_43_2","doi-asserted-by":"publisher","DOI":"10.1093\/carcin\/bgt492"},{"key":"e_1_2_9_44_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.biochi.2018.09.010"},{"key":"e_1_2_9_45_2","doi-asserted-by":"publisher","DOI":"10.3390\/nu11010060"},{"key":"e_1_2_9_46_2","doi-asserted-by":"publisher","DOI":"10.1155\/2018\/9364364"},{"key":"e_1_2_9_47_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.phymed.2018.11.028"},{"key":"e_1_2_9_48_2","doi-asserted-by":"publisher","DOI":"10.3389\/fphar.2016.00456"},{"key":"e_1_2_9_49_2","doi-asserted-by":"publisher","DOI":"10.1124\/mol.117.110155"},{"key":"e_1_2_9_50_2","doi-asserted-by":"publisher","DOI":"10.1289\/EHP6262"},{"key":"e_1_2_9_51_2","doi-asserted-by":"publisher","DOI":"10.1093\/toxsci\/kfn058"},{"key":"e_1_2_9_52_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41577-019-0125-8"},{"key":"e_1_2_9_53_2","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2019.05.066"},{"key":"e_1_2_9_54_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.isci.2018.05.006"},{"key":"e_1_2_9_55_2","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M800685200"},{"key":"e_1_2_9_56_2","doi-asserted-by":"publisher","DOI":"10.2353\/ajpath.2007.060391"},{"key":"e_1_2_9_57_2","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M111.258764"},{"key":"e_1_2_9_58_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.cair.2006.04.002"},{"key":"e_1_2_9_59_2","doi-asserted-by":"publisher","DOI":"10.1080\/10715762.2019.1608982"},{"key":"e_1_2_9_60_2","doi-asserted-by":"publisher","DOI":"10.1093\/toxsci\/kfu068"},{"key":"e_1_2_9_61_2","doi-asserted-by":"publisher","DOI":"10.1186\/s13046-019-1052-z"},{"key":"e_1_2_9_62_2","doi-asserted-by":"publisher","DOI":"10.3390\/ijms19072140"}],"container-title":["Oxidative Medicine and Cellular Longevity"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/downloads.hindawi.com\/journals\/omcl\/2021\/6635080.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/downloads.hindawi.com\/journals\/omcl\/2021\/6635080.xml","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1155\/2021\/6635080","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,8,7]],"date-time":"2024-08-07T14:55:22Z","timestamp":1723042522000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1155\/2021\/6635080"}},"subtitle":[],"editor":[{"given":"Silvana","family":"Hrelia","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"editor"}]}],"short-title":[],"issued":{"date-parts":[[2021,1]]},"references-count":62,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2021,1]]}},"alternative-id":["10.1155\/2021\/6635080"],"URL":"https:\/\/doi.org\/10.1155\/2021\/6635080","archive":["Portico"],"relation":{},"ISSN":["1942-0900","1942-0994"],"issn-type":[{"value":"1942-0900","type":"print"},{"value":"1942-0994","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,1]]},"assertion":[{"value":"2020-10-07","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2021-02-26","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2021-03-11","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"6635080"}}