{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T21:15:19Z","timestamp":1791321319005,"version":"4.3.1"},"reference-count":48,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2021,1,18]],"date-time":"2021-01-18T00:00:00Z","timestamp":1610928000000},"content-version":"vor","delay-in-days":17,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100004829","name":"Science and Technology Department of Sichuan Province","doi-asserted-by":"publisher","award":["2019YFH0025"],"award-info":[{"award-number":["2019YFH0025"]}],"id":[{"id":"10.13039\/501100004829","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004829","name":"Science and Technology Department of Sichuan Province","doi-asserted-by":"publisher","award":["2020YJ0296"],"award-info":[{"award-number":["2020YJ0296"]}],"id":[{"id":"10.13039\/501100004829","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81600864"],"award-info":[{"award-number":["81600864"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["BioMed Research International"],"published-print":{"date-parts":[[2021,1]]},"abstract":"<jats:p>\n                    <jats:italic>Background<\/jats:italic>\n                    . Chemotherapy is the primary treatment modality used for patients with acute lymphoblastic leukemia (ALL), but inevitably causes microbiota\u2010related oral complications. This study is aimed at investigating the effects of chemotherapy on oral health status, caries risk, and oral microbiome in pediatric patients with ALL.\n                    <jats:italic>Methods<\/jats:italic>\n                    . Thirty\u2010nine children with ALL receiving chemotherapy were enrolled, and a gender\u2010, age\u2010, dentition stage, and socioeconomic class matched healthy counterpart were recruited. Demographic information and overall health condition were obtained through the questionnaire and medical records. Oral examination was performed to assess caries and salivary status, plaque index, and other oral manifestations. Cariogram was used to assess the overall caries risk. Supragingival samples of thirteen ALL subjects and their counterparts were randomly selected to perform a 16S ribosomal RNA gene 454 pyrosequencing. Raw sequence data were screened, trimmed, and filtered using Seqcln and MOTHUR.\n                    <jats:italic>Results<\/jats:italic>\n                    . The prevalence of dental caries, gingivitis, oral mucositis, xerostomia, and candidiasis in ALL groups was higher than that of the control group (\n                    <jats:italic>p<\/jats:italic>\n                    &lt; 0.05). Children with ALL demonstrated higher caries risk compared to healthy controls (HC) based upon Cariogram (\n                    <jats:italic>p<\/jats:italic>\n                    &lt; 0.05). The oral microbial structure of ALL patients receiving chemotherapy is different from that of healthy controls. Oral microbiota of ALL groups showed less alpha diversity and significant differences in the composition of the oral microbiome compared to healthy controls.\n                    <jats:italic>Conclusions<\/jats:italic>\n                    . ALL patients receiving chemotherapy demonstrated compromised oral health, high caries risk, alteration of caries\u2010related factors, and dysbiosis of oral microbiota. These findings may be of clinical importance in developing better strategies for personalized preventive management of oral diseases for pediatric children with ALL.\n                  <\/jats:p>","DOI":"10.1155\/2021\/6637503","type":"journal-article","created":{"date-parts":[[2021,1,18]],"date-time":"2021-01-18T13:50:16Z","timestamp":1610977816000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":30,"title":["Oral Health, Caries Risk Profiles, and Oral Microbiome of Pediatric Patients with Leukemia Submitted to Chemotherapy"],"prefix":"10.1155","volume":"2021","author":[{"given":"Yan","family":"Wang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xinyi","family":"Zeng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xue","family":"Yang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiajia","family":"Que","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qin","family":"Du","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5039-4648","authenticated-orcid":false,"given":"Qiong","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3618-9672","authenticated-orcid":false,"given":"Jing","family":"Zou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2021,1,18]]},"reference":[{"key":"e_1_2_11_1_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(19)33018-1"},{"key":"e_1_2_11_2_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41568-018-0015-6"},{"key":"e_1_2_11_3_2","first-page":"641","article-title":"Guidelines for the diagnosis and treatment of childhood acute lymphoblastic leukemia","volume":"52","author":"Subspecialty Group of Hematology, the Society of Pediatrics, Chinese Medical Association","year":"2014","journal-title":"Zhonghua Er Ke Za Zhi"},{"key":"e_1_2_11_4_2","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2013.53.0808"},{"key":"e_1_2_11_5_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijporl.2007.07.006"},{"key":"e_1_2_11_6_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0199574"},{"key":"e_1_2_11_7_2","doi-asserted-by":"publisher","DOI":"10.1111\/jop.12266"},{"key":"e_1_2_11_8_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.oraloncology.2010.02.025"},{"key":"e_1_2_11_9_2","doi-asserted-by":"publisher","DOI":"10.17796\/1053-4628-42.3.11"},{"key":"e_1_2_11_10_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00520-017-3829-y"},{"key":"e_1_2_11_11_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00520-010-0873-2"},{"key":"e_1_2_11_12_2","doi-asserted-by":"publisher","DOI":"10.1111\/ipd.12476"},{"key":"e_1_2_11_13_2","doi-asserted-by":"publisher","DOI":"10.1186\/s12903-018-0585-4"},{"key":"e_1_2_11_14_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0528.2005.00233.x"},{"key":"e_1_2_11_15_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jdent.2017.04.010"},{"key":"e_1_2_11_16_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1875-595x.2007.tb00122.x"},{"key":"e_1_2_11_17_2","doi-asserted-by":"publisher","DOI":"10.1007\/s002620050616"},{"key":"e_1_2_11_18_2","first-page":"132","article-title":"Oral diseases in children with acute lymphoblastic leukemia with chemotherapy treatment","volume":"56","author":"Ju\u00e1rez-L\u00f3pez M. L. A.","year":"2018","journal-title":"Revista medica del Instituto Mexicano del Seguro Social"},{"key":"e_1_2_11_19_2","doi-asserted-by":"publisher","DOI":"10.1007\/s40368-019-00454-4"},{"key":"e_1_2_11_20_2","doi-asserted-by":"publisher","DOI":"10.5935\/1808-8694.20140015"},{"key":"e_1_2_11_21_2","doi-asserted-by":"publisher","DOI":"10.1093\/oxfordjournals.jncimonographs.a003437"},{"key":"e_1_2_11_22_2","first-page":"21","article-title":"Oral complications of cancer therapies. Infectious and noninfectious systemic consequences","volume":"9","author":"Wingard J. R.","year":"1990","journal-title":"National Cancer Institute Monographs"},{"key":"e_1_2_11_23_2","doi-asserted-by":"publisher","DOI":"10.1093\/infdis\/137.1.14"},{"key":"e_1_2_11_24_2","doi-asserted-by":"publisher","DOI":"10.1128\/JB.00542-10"},{"key":"e_1_2_11_25_2","doi-asserted-by":"publisher","DOI":"10.1186\/s12903-019-0947-6"},{"key":"e_1_2_11_26_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0063139"},{"key":"e_1_2_11_27_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00248-010-9712-8"},{"key":"e_1_2_11_28_2","doi-asserted-by":"publisher","DOI":"10.1038\/ismej.2011.71"},{"key":"e_1_2_11_29_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0056343"},{"key":"e_1_2_11_30_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.archoralbio.2015.05.006"},{"key":"e_1_2_11_31_2","doi-asserted-by":"publisher","DOI":"10.1038\/ijos.2013.15"},{"key":"e_1_2_11_32_2","volume-title":"Oral Health Surveys: Basic Methods-5th Edition","author":"World Health Organization"},{"key":"e_1_2_11_33_2","doi-asserted-by":"publisher","DOI":"10.3109\/00016356408993968"},{"key":"e_1_2_11_34_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0102116"},{"key":"e_1_2_11_35_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pcbi.1000352"},{"key":"e_1_2_11_36_2","doi-asserted-by":"publisher","DOI":"10.4103\/1735-3327.208764"},{"key":"e_1_2_11_37_2","doi-asserted-by":"publisher","DOI":"10.17796\/jcpd.34.3.y060151580h301t7"},{"key":"e_1_2_11_38_2","doi-asserted-by":"publisher","DOI":"10.17796\/jcpd.32.4.0p1462t621w20477"},{"key":"e_1_2_11_39_2","first-page":"47","article-title":"Etiology and outcome of oral mucosal lesions in children on chemotherapy for acute lymphoblastic leukemia","volume":"45","author":"Anirudhan D.","year":"2008","journal-title":"Indian Pediatrics"},{"key":"e_1_2_11_40_2","doi-asserted-by":"publisher","DOI":"10.17796\/jcpd.35.3.u5kx28q33m760834"},{"key":"e_1_2_11_41_2","doi-asserted-by":"publisher","DOI":"10.4103\/0971-5851.133717"},{"key":"e_1_2_11_42_2","doi-asserted-by":"publisher","DOI":"10.1111\/idj.12378"},{"key":"e_1_2_11_43_2","doi-asserted-by":"publisher","DOI":"10.2319\/012708-47.1"},{"key":"e_1_2_11_44_2","doi-asserted-by":"publisher","DOI":"10.2319\/040911-253.1"},{"key":"e_1_2_11_45_2","doi-asserted-by":"publisher","DOI":"10.1902\/jop.2011.100655"},{"key":"e_1_2_11_46_2","first-page":"391","article-title":"Validation of three caries risk assessment tools for preschool children from areas with high caries prevalence","volume":"41","author":"Agouropoulos A.","year":"2019","journal-title":"Pediatric Dentistry"},{"key":"e_1_2_11_47_2","doi-asserted-by":"publisher","DOI":"10.1186\/s13073-017-0409-1"},{"key":"e_1_2_11_48_2","doi-asserted-by":"publisher","DOI":"10.1186\/s40168-019-0679-5"}],"container-title":["BioMed Research International"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/downloads.hindawi.com\/journals\/bmri\/2021\/6637503.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/downloads.hindawi.com\/journals\/bmri\/2021\/6637503.xml","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1155\/2021\/6637503","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,12,31]],"date-time":"2024-12-31T11:15:06Z","timestamp":1735643706000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1155\/2021\/6637503"}},"subtitle":[],"editor":[{"given":"Atsushi","family":"Harimaya","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"editor"}]}],"short-title":[],"issued":{"date-parts":[[2021,1]]},"references-count":48,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2021,1]]}},"alternative-id":["10.1155\/2021\/6637503"],"URL":"https:\/\/doi.org\/10.1155\/2021\/6637503","archive":["Portico"],"relation":{"has-preprint":[{"id-type":"doi","id":"10.21203\/rs.3.rs-97387\/v1","asserted-by":"object"}]},"ISSN":["2314-6133","2314-6141"],"issn-type":[{"value":"2314-6133","type":"print"},{"value":"2314-6141","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,1]]},"assertion":[{"value":"2020-11-17","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2021-01-06","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2021-01-18","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"6637503"}}