{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,29]],"date-time":"2025-10-29T19:41:57Z","timestamp":1761766917525,"version":"3.40.5"},"reference-count":94,"publisher":"Wiley","license":[{"start":{"date-parts":[[2021,5,13]],"date-time":"2021-05-13T00:00:00Z","timestamp":1620864000000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Evidence-Based Complementary and Alternative Medicine"],"published-print":{"date-parts":[[2021,5,13]]},"abstract":"<jats:p>Objective. Tripterygium wilfordii polyglycosides tablet (TGt) is an oral preparation extracted from plant Tripterygium wilfordii. It has the effects of anti-inflammation and inhibition of cellular and humoral immunity. However, many reports of adverse reactions caused by TGt have limited its application. In this paper, the clinical efficacy and safety of TGt in the treatment of chronic kidney disease (CKD) were verified by data mining and analysis, so as to provide theoretical data support for the application and development of TGt. Methods. A computer search of the following databases was conducted: PubMed, Web of Science, CBM, VIP, Wanfang Data, and CNKI. The search time limit is from the establishment of the database to September 2020. We searched for clinical randomized controlled trials of TGt in the treatment of CKD. The main types of CKD involved are nephrotic syndrome (NS), primary nephrotic syndrome (PNS), refractory nephrotic syndrome (RNS), and IgA nephropathy (IgAN). RevMan 5.2 and Stata 12.0 software were used to evaluate the literature quality and analyze the data. Finally, GRADEpro software was used to evaluate the quality of evidence. Results. According to the inclusion and exclusion criteria, 75 articles with a total of 6418 subjects were included. The results of the meta-analysis showed that TGt could reduce 24-hour urinary protein, increase serum albumin, improve clinical efficacy, and reduce disease recurrence rate in patients (<jats:inline-formula>\n                     <a:math xmlns:a=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M1\">\n                        <a:mi>P<\/a:mi>\n                        <a:mo>&lt;<\/a:mo>\n                        <a:mn>0.05<\/a:mn>\n                     <\/a:math>\n                  <\/jats:inline-formula>) with CKD compared with adrenocortical hormones or immunosuppressants. TGt could significantly reduce the level of serum creatinine (Scr) in patients with CKD (<jats:inline-formula>\n                     <c:math xmlns:c=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M2\">\n                        <c:mi>P<\/c:mi>\n                        <c:mo>&lt;<\/c:mo>\n                        <c:mn>0.05<\/c:mn>\n                     <\/c:math>\n                  <\/jats:inline-formula>), but it was not significant in reducing the level of blood urea nitrogen (<jats:inline-formula>\n                     <e:math xmlns:e=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M3\">\n                        <e:mi>P<\/e:mi>\n                        <e:mo>&gt;<\/e:mo>\n                        <e:mn>0.05<\/e:mn>\n                     <\/e:math>\n                  <\/jats:inline-formula>). In terms of safety evaluation, in patients with CKD, it could significantly reduce the incidence of gastrointestinal adverse reactions and neurogenic dizziness and headache (<jats:inline-formula>\n                     <g:math xmlns:g=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M4\">\n                        <g:mi>P<\/g:mi>\n                        <g:mo>&lt;<\/g:mo>\n                        <g:mn>0.05<\/g:mn>\n                     <\/g:math>\n                  <\/jats:inline-formula>). However, in terms of adverse reactions such as liver injury, respiratory infection, and leukopenia, TGt was as harmful as corticosteroids or immunosuppressants (<jats:inline-formula>\n                     <i:math xmlns:i=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M5\">\n                        <i:mi>P<\/i:mi>\n                        <i:mo>&lt;<\/i:mo>\n                        <i:mn>0.05<\/i:mn>\n                     <\/i:math>\n                  <\/jats:inline-formula>). The quality of the evidence was evaluated with GRADEpro software, and the results showed that TGt was strongly recommended for the treatment of CKD. Conclusion. TGt has certain efficacy in the treatment of CKD and has fewer side effects in certain types of diseases. The effect of TGt combined with other drugs is better than that of single use. This paper also has some limitations. Due to the limited number of the included studies, with all being from China, there may be methodological differences. Therefore, more high-quality literature data from different countries are needed.<\/jats:p>","DOI":"10.1155\/2021\/6640594","type":"journal-article","created":{"date-parts":[[2021,5,15]],"date-time":"2021-05-15T19:05:09Z","timestamp":1621105509000},"page":"1-27","source":"Crossref","is-referenced-by-count":6,"title":["Meta-Analysis of Clinical Efficacy and Safety of Tripterygium wilfordii Polyglycosides Tablets in the Treatment of Chronic Kidney Disease"],"prefix":"10.1155","volume":"2021","author":[{"given":"Yan-Li","family":"Guo","sequence":"first","affiliation":[{"name":"Shaanxi University of Traditional Chinese Medicine, Shaanxi 712046, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Feng","family":"Gao","sequence":"additional","affiliation":[{"name":"Shaanxi University of Traditional Chinese Medicine, Shaanxi 712046, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tai-Wei","family":"Dong","sequence":"additional","affiliation":[{"name":"Shaanxi University of Traditional Chinese Medicine, Shaanxi 712046, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yang","family":"Bai","sequence":"additional","affiliation":[{"name":"The Second Affiliated Hospital of Shaanxi University of Traditional Chinese Medicine, Shaanxi 712000, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Qiao","family":"Liu","sequence":"additional","affiliation":[{"name":"Shaanxi University of Traditional Chinese Medicine, Shaanxi 712046, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ruo-Lan","family":"Li","sequence":"additional","affiliation":[{"name":"Shaanxi University of Traditional Chinese Medicine, Shaanxi 712046, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6649-0458","authenticated-orcid":true,"given":"Shu-Ting","family":"Yan","sequence":"additional","affiliation":[{"name":"Shaanxi University of Traditional Chinese Medicine, Shaanxi 712046, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5828-602X","authenticated-orcid":true,"given":"Mei","family":"Chen","sequence":"additional","affiliation":[{"name":"Affiliated Hospital of Shaanxi University of Chinese Medicine, Shaanxi 712000, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7973-5584","authenticated-orcid":true,"given":"Pei-Feng","family":"Wei","sequence":"additional","affiliation":[{"name":"Shaanxi University of Traditional Chinese Medicine, Shaanxi 712046, China"},{"name":"The Second Affiliated Hospital of Shaanxi University of Traditional Chinese Medicine, Shaanxi 712000, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Miao-Miao","family":"Xi","sequence":"additional","affiliation":[{"name":"The Second Affiliated Hospital of Shaanxi University of Traditional Chinese Medicine, Shaanxi 712000, China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","reference":[{"key":"1","doi-asserted-by":"crossref","first-page":"11","DOI":"10.7326\/0003-4819-158-11-201306040-00007","article-title":"Evaluation and management of chronic kidney disease: synopsis of the kidney disease: improving global outcomes 2012 clinical practice guideline","volume":"158","author":"L. 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Jiang","year":"2016","journal-title":"Science Report"},{"key":"6","article-title":"Cachexia in chronic kidney disease: a link to defective central nervous system control of appetite","volume":"6","author":"M. We","year":"2005","journal-title":"Journal of Clinical Investigation"},{"key":"7","article-title":"Appetite-regulating hormones in chronic kidney disease patients","volume":"4","author":"G. F. Oner","year":"2020","journal-title":"Journal of Renal Nutrition"},{"issue":"06","key":"8","first-page":"471","article-title":"New progress in clinical research of nephrology","volume":"21","author":"L. Q. Xie","year":"2016","journal-title":"Chinese Journal Of Nephropathy"},{"key":"9","article-title":"Nephrotic syndrome","volume":"47","year":"2015","journal-title":"Primary Care"},{"issue":"3","key":"10","first-page":"179","article-title":"Progress in clinical application of polyglycosides of Tripterygium wilfordii","volume":"29","author":"S. Y. Yao Jiru","year":"2012","journal-title":"Chinese Journal of New Drugs and Clinical Medicine"},{"key":"11","first-page":"63","article-title":"Pharmacological study and clinical application of polyglycosides of Tripterygium wilfordii","volume":"5","author":"L. Fang","year":"2014","journal-title":"Proprietary Chinese Medicine"},{"issue":"4","key":"12","first-page":"66","article-title":"Recent research status of Tripterygium wilfordii in the treatment of nephrotic syndrome","volume":"11","author":"L. G. Yang","year":"2013","journal-title":"Journal of Liaoning University of Traditional Chinese Medicine"},{"volume-title":"Study on Draft Guidelines for Clinical Diagnosis and Treatment of Pediatric Nephrotic Syndrome Based on Standardization of Traditional Chinese Medicine","year":"2015","author":"L. Jiehong","key":"13"},{"key":"14","first-page":"1","article-title":"Research progress on adverse reactions and compatibility of polyglycosides of Tripterygium wilfordii","author":"Z. H. Jiang","year":"2013","journal-title":"Chinese Journal Of Traditional Chinese Medicine"},{"issue":"17","key":"15","first-page":"140","article-title":"Observation on the clinical effect of Tripterygium wilfordii polyglycosides tablets in the diagnosis and treatment of nephrotic syndrome in 30 cases","volume":"12","author":"T. Wei","year":"2007","journal-title":"Chinese Medicine Refers to the South"},{"issue":"31","key":"16","first-page":"119","article-title":"Analysis of the efficacy of Tripterygium wilfordii polyglycosides combined with hormone in the treatment of patients with nephropathy syndrome","volume":"24","author":"LiPeng","year":"2013","journal-title":"Cardiology Medicine and Students"},{"issue":"14","key":"17","first-page":"114","article-title":"Effects of Tripterygium wilfordii polyglycosides tablets combined with glucocorticoids on renal function and renal function in patients with nephrotic syndrome","volume":"28","author":"L. Minghua","year":"2008","journal-title":"Health and Nutrition in China"},{"key":"18","first-page":"105","article-title":"Clinical analysis of Tripterygium wilfordii polyglycosides tablets combined with corticosteroids in the treatment of patients with nephrotic syndrome","volume":"11","author":"S. Qingwan","year":"2002","journal-title":"Modern Health Preservation"},{"key":"19","first-page":"143","article-title":"Comparison of Tripterygium wilfordii polyglycosides and cyclophosphamide in the treatment of nephrotic syndrome","volume":"2","author":"G. Peng","year":"2013","journal-title":"Everyone\u2019s Health"},{"issue":"12","key":"20","first-page":"35","article-title":"Clinical efficacy of adding Tripterygium wilfordii polyglycosides tablets in the treatment of renal syndrome","volume":"15","author":"S. B. L. Yunqi","year":"2019","journal-title":"Glycosuria Heaven and Earth"},{"issue":"4","key":"21","first-page":"843","article-title":"Comparative analysis of clinical therapeutic effects of different prescriptions in the treatment of renal syndromes","volume":"26","author":"Y. Lan","year":"2014","journal-title":"Present Diagnosis And Treatment"},{"issue":"12","key":"22","first-page":"58","article-title":"Analysis of clinical efficacy of different methods in the treatment of nephrotic syndrome","volume":"32","author":"X. Y. Chang","year":"2019","journal-title":"Chinese and Foreign Medicine"},{"issue":"5","key":"23","first-page":"631","article-title":"Observation on the efficacy of prednisone acetate and cyclophosphamide pulse therapy combined with Tripterygium wilfordii polyglycosides in the treatment of nephrotic syndrome","volume":"30","author":"Y. Y. Deng","year":"2008","journal-title":"Clinical Research in China"},{"issue":"3","key":"24","first-page":"683","article-title":"Efficacy of methylprednisolone combined with Tripterygium wilfordii in the treatment of senile nephrotic syndrome","volume":"34","author":"D. H. Jiang Xiaoli","year":"2019","journal-title":"Chinese Journal of Old Age Studies"},{"issue":"36","key":"25","first-page":"7261","article-title":"Clinical observation of methylprednisolone combined with Tripterygium wilfordii polyglycosides in the treatment of senile nephrotic syndrome","volume":"3","author":"J. Chunxia","year":"2019","journal-title":"Electronic Journal of Clinical Medical Literature"},{"issue":"11","key":"26","first-page":"1589","article-title":"Clinical analysis of methylprednisolone combined with Tripterygium wilfordii polyglycosides in the treatment of senile nephrotic syndrome","volume":"16","author":"X. L. Liao","year":"2017","journal-title":"Modern Medical Hospital"},{"issue":"2","key":"27","first-page":"58","article-title":"Study on the efficacy of methylprednisolone combined with Tripterygium wilfordii in the treatment of senile nephrotic syndrome","volume":"18","author":"W. Danguo","year":"2017","journal-title":"Chinese Medicine Refers to the South"},{"issue":"5","key":"28","first-page":"176","article-title":"Observation on the efficacy of Tripterygium wilfordii combined with prednisolone in the treatment of nephrotic syndrome","volume":"42","author":"S. J. Zhang","year":"2017","journal-title":"Heilongjiang Medicine and Pharmacology"},{"issue":"20","key":"29","first-page":"3051","article-title":"Effect of Tripterygium wilfordii combined with glucocorticoid on regulatory T cells in patients with nephrotic syndrome","volume":"30","author":"X. L. Deng","year":"2007","journal-title":"Modern Medicine and Health"},{"issue":"18","key":"30","first-page":"2745","article-title":"Evaluation of the efficacy of Tripterygium wilfordii combined with glucocorticoid in patients with nephrotic syndrome","volume":"31","author":"Z. Zhaoxie","year":"2007","journal-title":"Medical Theory and Practice"},{"issue":"3","key":"31","first-page":"310","article-title":"Efficacy of Tripterygium wilfordii combined with glucocorticoid in the treatment of nephrotic syndrome","volume":"36","author":"W. X. Niu","year":"2007","journal-title":"Anhui Medicine"},{"issue":"11","key":"32","first-page":"89","article-title":"Clinical efficacy and safety of Tripterygium wilfordii polyglycoside combined with prednisone acetate in the treatment of nephrotic syndrome","volume":"14","author":"Z. P. Guang","year":"2007","journal-title":"Chinese Pharmacoeconomics"},{"issue":"12","key":"33","first-page":"110","article-title":"Clinical analysis of Tripterygium wilfordii polyglycosides combined with cyclophosphamide in the treatment of 60 cases of nephrotic syndrome","volume":"10","author":"Y. Lingzhi","year":"2009","journal-title":"Asia-Pacific Traditional Medicine"},{"issue":"36","key":"34","first-page":"19","article-title":"Clinical observation of Tripterygium wilfordii polyglycosides combined with cyclophosphamide in the treatment of nephrotic syndrome","volume":"5","author":"C. Fang","year":"2007","journal-title":"Clinical Rational Use of Drugs"},{"issue":"5","key":"35","first-page":"511","article-title":"Clinical study of multi-target therapy on renal function of refractory adult nephrotic syndrome","volume":"26","author":"L. Qian","year":"2007","journal-title":"Southwest National Defense Medicine"},{"issue":"9","key":"36","first-page":"80","article-title":"Effects of Tripterygium wilfordii polyglycosides combined with mycophenolate mofetil on renal function and recurrence rate in patients with nephrotic syndrome","volume":"16","author":"G. Xiaofeng","year":"2009","journal-title":"Exploration of Rational Drug Use in China"},{"issue":"7","key":"37","first-page":"889","article-title":"Clinical analysis of Tripterygium wilfordii polyglycosides combined with mycophenolate mofetil in the treatment of nephrotic syndrome","volume":"29","author":"N. Ying","year":"2009","journal-title":"Modern Practical Medicine"},{"issue":"11","key":"38","first-page":"1592","article-title":"Clinical study of Tripterygium wilfordii combined with immunosuppressant in the treatment of nephrotic syndrome","volume":"39","author":"W. J. Zhao","year":"2009","journal-title":"Shaanxi Traditional Chinese Medicine"},{"issue":"11","key":"39","first-page":"92","article-title":"Effects of Tripterygium wilfordii polyglycosides combined with prednisone on serum inflammatory mediators and renal function in patients with nephrotic syndrome","volume":"14","author":"W. Wensheng","year":"2009","journal-title":"Chinese Pharmacoeconomics"},{"issue":"19","key":"40","first-page":"100","article-title":"Clinical effect of Tripterygium wilfordii polyglycosides tablets combined with prednisone in the treatment of nephrotic syndrome","volume":"26","author":"X. Xinrong","year":"2009","journal-title":"Chinese Contemporary Medicine"},{"issue":"5","key":"41","first-page":"138","article-title":"Effects of Tripterygium wilfordii polyglycosides tablets combined with glucocorticoids on efficacy, renal function and serum inflammatory factors in patients with nephrotic syndrome","volume":"14","author":"L. Fan","year":"2008","journal-title":"Journal of Hunan Normal University (Medical Edition)"},{"issue":"8","key":"42","first-page":"1122","article-title":"Analysis of clinical efficacy of Tripterygium wilfordii polyglycosides combined with glucocorticoid in the treatment of patients with nephrotic syndrome and its effect on serum inflammatory factors","volume":"10","author":"Z. Zhifang","year":"2008","journal-title":"World Journal of Integrated Traditional Chinese and Western Medicine"},{"issue":"13","key":"43","first-page":"28","article-title":"Efficacy of Tripterygium wilfordii polyglycosides combined with glucocorticoid in the treatment of nephrotic syndrome","volume":"29","author":"L. Lijun","year":"2005","journal-title":"Mixed Records of Shenzhen Integrated Traditional Chinese and Western Medicine"},{"issue":"5","key":"44","first-page":"65","article-title":"Comparative study of Tripterygium wilfordii polyglycosides and cyclophosphamide in the treatment of nephrotic syndrome","volume":"27","author":"L. Zhimou","year":"2005","journal-title":"Drugs and People"},{"issue":"3","key":"45","first-page":"510","article-title":"Clinical analysis of 50 cases of nephrotic syndrome treated with Tripterygium wilfordii","volume":"35","author":"h.J. Liu Shusheng","year":"2005","journal-title":"Jilin Medicine"},{"issue":"21","key":"46","first-page":"137","article-title":"Clinical observation of prednisone combined with Tripterygium wilfordii in the treatment of nephrotic syndrome","volume":"20","author":"Z. Huiqing","year":"2013","journal-title":"Contemporary Medicine"},{"issue":"11","key":"47","first-page":"1366","article-title":"Preliminary evaluation on the effect of Tripterygium wilfordii combined with hormone in the treatment of nephrotic syndrome","volume":"28","author":"L. X. Lihua","year":"2013","journal-title":"Journal of Aeronautical and Aerospace Medicine"},{"issue":"7","key":"48","first-page":"831","article-title":"Clinical observation on the treatment of nephrotic syndrome with combination of traditional Chinese and western medicine","volume":"35","author":"Z. Baoguo","year":"2013","journal-title":"Journal of Practical Traditional Chinese Medicine"},{"issue":"12","key":"49","first-page":"107","article-title":"Observation on the efficacy of Tripterygium wilfordii polyglycosides combined with glucocorticoid in the treatment of refractory nephrotic syndrome","volume":"11","author":"L. Yi","year":"2013","journal-title":"World Clinical Medicine"},{"issue":"46","key":"50","first-page":"58","article-title":"Evaluation of the efficacy of leflunomide combined with Tripterygium wilfordii polyglycosides in the treatment of refractory nephrotic syndrome","volume":"5","author":"Z. Tingting","year":"2013","journal-title":"Diet to Keep Healthy"},{"issue":"5","key":"51","first-page":"511","article-title":"Clinical study on renal function of refractory adult nephrotic syndrome treated by multi-target therapy","volume":"26","author":"L. Qian","year":"2011","journal-title":"Southwest Defense Medicine"},{"issue":"3","key":"52","first-page":"382","article-title":"Clinical analysis of cyclophosphamide combined with Tripterygium wilfordii polyglycosides in the treatment of hormone-dependent nephrotic syndrome","volume":"12","author":"N. Qing","year":"2011","journal-title":"Internal Medicine"},{"issue":"6","key":"53","first-page":"105","article-title":"Observation on the efficacy of leflunomide combined with Tripterygium wilfordii polyglycosides in the treatment of refractory nephrotic syndrome","volume":"56","author":"G. Yong","year":"2011","journal-title":"Chinese Modern Medicine and Students"},{"issue":"12","key":"54","first-page":"139","article-title":"Effect of Tripterygium wilfordii polyglycosides combined with mycophenolate mofetil on renal function in patients with refractory nephrotic syndrome","volume":"36","author":"G. Xiaoping","year":"2014","journal-title":"Chinese and Foreign Medical Treatment"},{"issue":"11","key":"55","first-page":"112","article-title":"Effects of Tripterygium wilfordii polyglycosides tablets on blood lipids, urinary protein, renal tissue KIM-1 and urinary TH glycoprotein in patients with refractory nephrotic syndrome","volume":"17","author":"Z. Q. Wan","year":"2014","journal-title":"Journal of Liaoning University of Traditional Chinese Medicine"},{"issue":"1","key":"56","first-page":"137","article-title":"Effects of Tripterygium wilfordii polyglycosides tablets on urinary protein, inflammatory factors and immune function in patients with refractory nephrotic syndrome","volume":"28","author":"C. Q. Jiao","year":"2014","journal-title":"Clinical Research in China"},{"issue":"4","key":"57","first-page":"363","article-title":"Efficacy and renal function of mycophenolate mofetil combined with Tripterygium wilfordii polyglycosides in patients with refractory nephrotic syndrome","volume":"14","author":"C. F. Chen","year":"2004","journal-title":"Journal of Difficult and Difficult Diseases"},{"issue":"34","key":"58","first-page":"26","article-title":"Observation on the efficacy of mycophenolate mofetil combined with Tripterygium wilfordii polyglycosides in the treatment of patients with refractory nephrotic syndrome","volume":"12","author":"X. Hua","year":"2004","journal-title":"Journal of Clinical Rational Drug Use"},{"issue":"24","key":"59","first-page":"136","article-title":"Analysis of the effect of prednisone combined with Tripterygium wilfordii polyglycosides in the treatment of refractory nephrotic syndrome","volume":"11","author":"W. Xiaoxue","year":"2004","journal-title":"Chinese Practical Medicine"},{"issue":"19","key":"60","first-page":"129","article-title":"Analysis of the effect of Tripterygium wilfordii polyglycosides combined with glucocorticoid in the treatment of refractory nephrotic syndrome","volume":"12","author":"Q. M. Wang","year":"2004","journal-title":"A Series of Contemporary Medical Theories"},{"issue":"16","key":"61","first-page":"33","article-title":"Clinical analysis of glucocorticoid combined with Tripterygium wilfordii polyglycosides in the treatment of refractory nephrotic syndrome","volume":"19","author":"X. Qingyun","year":"2004","journal-title":"The New World of Diabetes"},{"issue":"4","key":"62","first-page":"958","article-title":"Observation on the efficacy of Tripterygium wilfordii combined with glucocorticoid in the treatment of refractory nephrotic syndrome","volume":"32","author":"X. C. Fan de Yong","year":"2004","journal-title":"Chinese Journal of Traditional Chinese Medicine"},{"issue":"23","key":"63","first-page":"90","article-title":"Short-term efficacy of double-dose Tripterygium wilfordii polyglycosides in the treatment of primary nephrotic syndrome","volume":"11","author":"X. Sufang","year":"2014","journal-title":"World Clinical Medicine"},{"key":"64","first-page":"174","article-title":"Comparative study of two drug regimens in the treatment of primary nephrotic syndrome","volume":"20","author":"W. Yongqing","year":"2018","journal-title":"Medical Frontier"},{"issue":"11","key":"65","first-page":"75","article-title":"Clinical observation of Tripterygium wilfordii polyglycosides combined with prednisone in the treatment of adult primary nephrotic syndrome","volume":"25","author":"L. Han","year":"2018","journal-title":"Chinese Medical Engineering Program"},{"issue":"6","key":"66","first-page":"519","article-title":"Observation on the efficacy of leflunomide combined with Tripterygium wilfordii polyglycosides and low-dose prednisone in the treatment of middle-aged and elderly patients with refractory nephrotic syndrome","volume":"7","author":"J. Ganru","year":"2014","journal-title":"New Clinical Medicine in China"},{"issue":"7","key":"67","first-page":"172","article-title":"Clinical study of Tripterygium wilfordii combined with small and medium dose prednisone in the treatment of senile primary nephrotic syndrome","volume":"9","author":"B. Yu","year":"2001","journal-title":"Asia-Pacific Traditional Medicine"},{"issue":"7","key":"68","first-page":"47","article-title":"Effect of Tripterygium wilfordii polyglycosides on serum indexes in elderly patients with primary nephrotic syndrome","volume":"21","author":"H. Y. Tian","year":"2019","journal-title":"Journal of Practical Clinical Medicine"},{"issue":"9","key":"69","first-page":"792","article-title":"Comparison of the efficacy of cyclophosphamide and Tripterygium wilfordii polyglycosides in the treatment of primary nephrotic syndrome in the middle-aged","volume":"24","author":"G. L. Lou","year":"2018","journal-title":"Zhejiang Journal of Combination of Chinese and Western Medicine"},{"issue":"1","key":"70","first-page":"179","article-title":"Effects of Tripterygium wilfordii polyglycosides combined with benazepril on renal function and serum immunoglobulin levels in elderly patients with primary nephrotic syndrome","volume":"24","author":"M. Y. Zhu","year":"2018","journal-title":"Anhui Medicine"},{"issue":"2","key":"71","first-page":"58","article-title":"Efficacy of Tripterygium wilfordii polyglycosides combined with ramipril in the treatment of senile primary nephrotic syndrome","volume":"16","author":"Z. Qian","year":"2018","journal-title":"Exploration of Rational Drug Use in China"},{"issue":"6","key":"72","first-page":"692","article-title":"Of Tripterygium wilfordii polyglycosides combined with immunosuppressant in the treatment of primary nephrotic syndrome","volume":"36","author":"N. Xiaoli","year":"2016","journal-title":"Chinese Journal of Metallurgical Industry Medicine"},{"issue":"4","key":"73","first-page":"108","article-title":"Efficacy of Tripterygium wilfordii combined with glucocorticoid in the treatment of patients with PNS","volume":"11","author":"H. X. Xu","year":"2016","journal-title":"Management of Health Standards in China"},{"issue":"2","key":"74","first-page":"76","article-title":"Clinical observation of Tripterygium wilfordii polyglycosides combined with low-dose prednisone in the treatment of senile primary nephrotic syndrome","volume":"25","author":"J. Liangyan","year":"2016","journal-title":"Strait Pharmacology"},{"issue":"10","key":"75","first-page":"1031","article-title":"Clinical observation of Tripterygium wilfordii polyglycosides combined with medium-dose prednisone in the treatment of senile primary nephrotic syndrome","volume":"8","author":"C. 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