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An ideal model would be relatively easy to use and reliable, besides being ethically acceptable. Furthermore, it would address the pathogenic features of the cardiovascular disease that one seeks to investigate. No universally valid model has been identified, even though a host of models have been developed. The object of this review is to describe several of the most relevant mathematical models of the cardiovascular system: the physiological features of circulatory dynamics are explained, and their mathematical formulations are compared. The focus is on the whole-body scale mathematical models that portray the subject\u2019s responses to hypovolemic shock. The models contained in this review differ from one another, both in the mathematical methodology adopted and in the physiological or pathological aspects described. Each model, in fact, mimics different aspects of cardiocirculatory physiology and pathophysiology to varying degrees: some of these models are geared to better understand the mechanisms of vascular hemodynamics, whereas others focus more on disease states so as to develop therapeutic standards of care or to test novel approaches. We will elucidate key issues involved in the modeling of cardiovascular system and its control by reviewing seven of these models developed to address these specific purposes.<\/jats:p>","DOI":"10.1155\/2021\/6640638","type":"journal-article","created":{"date-parts":[[2021,6,4]],"date-time":"2021-06-04T20:50:40Z","timestamp":1622839840000},"page":"1-34","source":"Crossref","is-referenced-by-count":7,"title":["Seven Mathematical Models of Hemorrhagic Shock"],"prefix":"10.1155","volume":"2021","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4571-1757","authenticated-orcid":true,"given":"Luciano","family":"Curcio","sequence":"first","affiliation":[{"name":"National Research Council of Italy, Institute for Biomedical Research and Innovation, Via Ugo La Malfa, 153, 90146 Palermo, Italy"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4899-9573","authenticated-orcid":true,"given":"Laura","family":"D'Orsi","sequence":"additional","affiliation":[{"name":"National Research Council of Italy, Institute for Systems Analysis and Computer Science \u201cA. 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