{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,7,30]],"date-time":"2025-07-30T15:01:07Z","timestamp":1753887667710,"version":"3.41.2"},"reference-count":47,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2021,8,5]],"date-time":"2021-08-05T00:00:00Z","timestamp":1628121600000},"content-version":"vor","delay-in-days":216,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["BioMed Research International"],"published-print":{"date-parts":[[2021,1]]},"abstract":"<jats:p><jats:italic>Background<\/jats:italic>. Lipid metabolism may be altered in red cell genetic disorders. The erythrocyte and plasma lipids are defected which may increase the risk of cardiovascular disease. In the present study, we hypothesized a possible link between severity of anemia and altered lipid profile in SCD. <jats:italic>Methods<\/jats:italic>. A total of 151 SCD patients, including 62 patients with sickle cell anemia (SS), 54 patients with sickle <jats:italic>\u03b2<\/jats:italic>\u2010thalassemia (ST), and 35 individuals with sickle cell trait (AS), were studied. The control group consisted of 160 healthy individuals. Total cholesterol (TC), triglyceride (TG), and high\u2010density lipoprotein cholesterol (HDL\u2010C) were enzymatically measured. <jats:italic>Results<\/jats:italic>. Total cholesterol and LDL\u2010C were significantly lower (<jats:italic>P<\/jats:italic> value &lt; 0.001) in SS and ST patients compared to AS individuals and AA controls. However, LDL\u2010C was significantly lower in AS individuals (both males and female) compared to AA controls (<jats:italic>P<\/jats:italic> value &lt; 0.001). The HDL\u2010C in SS and ST patients (both males and females) was significantly lower than that in AS individuals (<jats:italic>P<\/jats:italic> value &lt; 0.001). In addition, the HDL\u2010C was significantly higher in SS and ST males and AS (males and females) compared to AA controls (<jats:italic>P<\/jats:italic> value &lt; 0.001). The HDL\u2010C was also significantly higher in SS males (<jats:italic>P<\/jats:italic> value &lt; 0.001) and females (<jats:italic>P<\/jats:italic> value &lt; 0.05) compared to ST patients. The HDL\u2010C was significantly higher in AS individuals (<jats:italic>P<\/jats:italic> value &lt; 0.001) compared to AA controls. The triglycerides in SS males was significantly lower than that in ST patients (<jats:italic>P<\/jats:italic> value &lt; 0.001), but there was no significant difference when compared to AS individuals and AA controls. In contrast, triglycerides in SS females were significantly lower than those in ST (<jats:italic>P<\/jats:italic> value &lt; 0.05), AS (<jats:italic>P<\/jats:italic> value &lt; 0.001), and AA controls (<jats:italic>P<\/jats:italic> value &lt; 0.001). In males of ST patients, triglycerides were significantly higher than those observed in AS males and AA males (<jats:italic>P<\/jats:italic> value &lt; 0.001). In contrast, females of ST patients have a significantly lower triglycerides compared to AS and AA females (<jats:italic>P<\/jats:italic> value &lt; 0.001). <jats:italic>Conclusions<\/jats:italic>. In SCD, the plasma is affected in some way, especially the plasma cholesterol that was investigated in this study. Further prospective studies should examine the contribution of an altered lipid profile to the severity and clinical complications in SCD patients.<\/jats:p>","DOI":"10.1155\/2021\/6640956","type":"journal-article","created":{"date-parts":[[2021,8,5]],"date-time":"2021-08-05T20:05:07Z","timestamp":1628193907000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Plasma Lipids and Lipoproteins in Sickle Cell Disease Patients in the Northern West Bank, Palestine"],"prefix":"10.1155","volume":"2021","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2925-4875","authenticated-orcid":false,"given":"Fekri","family":"Samarah","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9333-4856","authenticated-orcid":false,"given":"Mahmoud A.","family":"Srour","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2039-927X","authenticated-orcid":false,"given":"Kamal","family":"Dumaidi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2021,8,5]]},"reference":[{"key":"e_1_2_12_1_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2257.1998.00037.x"},{"key":"e_1_2_12_2_2","first-page":"1771","article-title":"Prenatal diagnosis of beta-thalassemia in the west Bank and Gaza","volume":"26","author":"Ayesh S. 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