{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,3]],"date-time":"2026-07-03T08:49:14Z","timestamp":1783068554708,"version":"3.54.6"},"reference-count":61,"publisher":"Wiley","license":[{"start":{"date-parts":[[2021,5,15]],"date-time":"2021-05-15T00:00:00Z","timestamp":1621036800000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100003968","name":"Iran National Science Foundation","doi-asserted-by":"publisher","award":["39119"],"award-info":[{"award-number":["39119"]}],"id":[{"id":"10.13039\/501100003968","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003968","name":"Iran National Science Foundation","doi-asserted-by":"publisher","award":["37827"],"award-info":[{"award-number":["37827"]}],"id":[{"id":"10.13039\/501100003968","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Dr. Almasian Post Doc. Research","award":["39119"],"award-info":[{"award-number":["39119"]}]},{"name":"Dr. Almasian Post Doc. Research","award":["37827"],"award-info":[{"award-number":["37827"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Evidence-Based Complementary and Alternative Medicine"],"published-print":{"date-parts":[[2021,5,15]]},"abstract":"<jats:p>Diabetic ulcer is regarded as one of the most prevalent chronic diseases. The healing of these ulcers enhances with the use of herbal extracts containing wound dressings with high antibacterial property and creating a nano-sized controlled release system. In this study, new peppermint extract was incorporated in the polyurethane- (PU-) based nanofibers for diabetic wound healing. The peppermint extract was used as an herbal antimicrobial and anti-inflammatory agent. The absorption ability of the wound dressing was enhanced by addition of F127 pluronic into the polymer matrix. The release of the extract was optimized by crosslinking the extract with gelatin nanoparticles (CGN) and their eventual incorporation into the nanofibers. The release of the extract was also controlled through direct addition of the extract into the PU matrix. The results showed that the release of extract from nanofibers was continued during 144 hours. The prepared wound dressing had a maximum absorption of 410.65% and an antibacterial property of 99.9% against Staphylococcus aureus and Escherichia coli bacteria. An in vivo study indicated on significant improving in wound healing after the use of the extract as an effective compound. On day 14, the average healing rate for samples covered by conventional gauze bandage, PU\/F127, PU\/F\/15 (contained extract), and PU\/F\/15\/10 (contained extract and CGN) prepared with different nanoparticle concentrations of 5 and 10 was 47.1\u2009\u00b1\u20090.2, 56.4\u2009\u00b1\u20090.4, 65.14\u2009\u00b1\u20090.2, and 90.55\u2009\u00b1\u20090.15%, respectively. Histopathological studies indicated that the wound treated with the extract containing nanofibers showed a considerable inflammation reduction at day 14. Additionally, this group showed more resemblance to normal skin with a thin epidermis presence of normal rete ridges and rejuvenation of skin appendages. Neovascularization and collagen deposition were higher in wounds treated with the extract containing nanofibrous wound dressing compared to the other groups.<\/jats:p>","DOI":"10.1155\/2021\/6646702","type":"journal-article","created":{"date-parts":[[2021,5,15]],"date-time":"2021-05-15T20:20:09Z","timestamp":1621110009000},"page":"1-16","source":"Crossref","is-referenced-by-count":29,"title":["Preparation of Polyurethane\/Pluronic F127 Nanofibers Containing Peppermint Extract Loaded Gelatin Nanoparticles for Diabetic Wounds Healing: Characterization, In Vitro, and In Vivo Studies"],"prefix":"10.1155","volume":"2021","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2992-0479","authenticated-orcid":true,"given":"Arash","family":"Almasian","sequence":"first","affiliation":[{"name":"Department of Pharmacognosy, Faculty of Pharmacy, Tehran University of Medical Sciences, Tehran, Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3094-1322","authenticated-orcid":true,"given":"Farhood","family":"Najafi","sequence":"additional","affiliation":[{"name":"Department of Resin and Additives, Institute for Color Science and Technology, Tehran, Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2786-5111","authenticated-orcid":true,"given":"Mahdieh","family":"Eftekhari","sequence":"additional","affiliation":[{"name":"Department of Pharmacognosy, Faculty of Pharmacy, Kermanshah University of Medical Sciences, Tehran, Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7326-5788","authenticated-orcid":true,"given":"Mohammad Reza","family":"Shams Ardekani","sequence":"additional","affiliation":[{"name":"Department of Pharmacognosy, Faculty of Pharmacy, Tehran University of Medical Sciences, Tehran, Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2991-7384","authenticated-orcid":true,"given":"Mohammad","family":"Sharifzadeh","sequence":"additional","affiliation":[{"name":"Department of Toxicology, Faculty of Pharmacy, Tehran University of Medical Sciences, Tehran, Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4053-6331","authenticated-orcid":true,"given":"Mahnaz","family":"Khanavi","sequence":"additional","affiliation":[{"name":"Department of Pharmacognosy, Faculty of Pharmacy and Persian Medicine and Pharmacy Research Center, Tehran University of Medical Sciences, Tehran, Iran"},{"name":"Faculty of Land and Food Systems, University of British Columbia, Vancouver, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","reference":[{"key":"1","doi-asserted-by":"publisher","DOI":"10.1016\/j.fitote.2010.05.001"},{"key":"2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jconrel.2016.09.017"},{"key":"3","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijpharm.2007.09.008"},{"key":"4","doi-asserted-by":"publisher","DOI":"10.1263\/jbb.102.425"},{"key":"5","doi-asserted-by":"publisher","DOI":"10.1007\/s12274-011-0150-9"},{"key":"6","doi-asserted-by":"publisher","DOI":"10.1016\/j.polymer.2015.04.083"},{"key":"7","doi-asserted-by":"publisher","DOI":"10.1590\/1980-5373-mr-2017-0488"},{"key":"8","doi-asserted-by":"publisher","DOI":"10.1016\/j.carbpol.2010.04.048"},{"key":"9","doi-asserted-by":"publisher","DOI":"10.1016\/j.colsurfb.2015.10.039"},{"key":"10","doi-asserted-by":"publisher","DOI":"10.1016\/j.foodhyd.2009.03.010"},{"key":"11","doi-asserted-by":"publisher","DOI":"10.1016\/j.jconrel.2013.09.019"},{"key":"12","doi-asserted-by":"publisher","DOI":"10.1016\/j.apsusc.2009.10.069"},{"key":"13","doi-asserted-by":"publisher","DOI":"10.1007\/s10856-006-8235-9"},{"key":"14","doi-asserted-by":"publisher","DOI":"10.1016\/j.msec.2020.111039"},{"key":"15","doi-asserted-by":"publisher","DOI":"10.1021\/acsinfecdis.0c00321"},{"key":"16","doi-asserted-by":"publisher","DOI":"10.1002\/jbm.b.33078"},{"key":"17","doi-asserted-by":"publisher","DOI":"10.1111\/j.1440-1681.2009.05216.x"},{"key":"18","doi-asserted-by":"publisher","DOI":"10.1007\/s11694-014-9171-x"},{"key":"19","doi-asserted-by":"publisher","DOI":"10.1016\/j.foodchem.2016.09.179"},{"key":"20","doi-asserted-by":"publisher","DOI":"10.3389\/fbioe.2019.00346"},{"key":"21","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijbiomac.2020.02.102"},{"key":"22","doi-asserted-by":"publisher","DOI":"10.3390\/ijms16010805"},{"key":"23","doi-asserted-by":"publisher","DOI":"10.1016\/j.lwt.2010.12.002"},{"key":"24","doi-asserted-by":"publisher","DOI":"10.1093\/jac\/dkq105"},{"key":"25","doi-asserted-by":"publisher","DOI":"10.1016\/j.jiec.2015.08.002"},{"key":"26","doi-asserted-by":"publisher","DOI":"10.1016\/j.jtice.2016.07.037"},{"key":"27","doi-asserted-by":"publisher","DOI":"10.1016\/j.polymer.2005.04.040"},{"key":"28","doi-asserted-by":"publisher","DOI":"10.1016\/j.foodchem.2012.11.069"},{"key":"29","doi-asserted-by":"publisher","DOI":"10.1016\/j.sna.2012.08.004"},{"key":"30","doi-asserted-by":"publisher","DOI":"10.1016\/j.foodhyd.2015.03.006"},{"key":"31","doi-asserted-by":"publisher","DOI":"10.1016\/j.compositesb.2013.04.037"},{"key":"32","doi-asserted-by":"publisher","DOI":"10.1016\/j.cej.2017.06.040"},{"key":"33","doi-asserted-by":"publisher","DOI":"10.1016\/j.polymer.2008.01.028"},{"key":"34","doi-asserted-by":"publisher","DOI":"10.1016\/j.compositesb.2012.07.052"},{"key":"35","doi-asserted-by":"publisher","DOI":"10.1016\/j.polymertesting.2017.05.008"},{"key":"36","doi-asserted-by":"publisher","DOI":"10.1016\/j.colsurfa.2012.09.029"},{"key":"37","doi-asserted-by":"publisher","DOI":"10.1002\/adfm.201910748"},{"key":"38","doi-asserted-by":"publisher","DOI":"10.1016\/j.cej.2020.124888"},{"key":"39","doi-asserted-by":"crossref","DOI":"10.1201\/9781420079944","volume-title":"Microbiology of Wounds","author":"S. Percival","year":"2010"},{"key":"40","doi-asserted-by":"publisher","DOI":"10.31248\/JDPS2018.015"},{"key":"41","first-page":"34","article-title":"Composition of the volatile oil of Achillea conferta DC. from Iran","volume":"13","author":"S. Saeidnia","year":"2005","journal-title":"DARU Journal of Pharmaceutical Sciences"},{"key":"42","first-page":"179","article-title":"Recent advances in research of antimicrobial effects of essential oils and plant derived compounds on bacteria","volume":"6","author":"Z. Schelz","year":"2010","journal-title":"Ethnomedicine: A Source of Complementary Therapeutics"},{"key":"43","first-page":"107","article-title":"Optimisation des conditions d\u2019extraction des polyph\u00e9nols de dattes lyophilis\u00e9es (Phoenix dactylifera L.) vari\u00e9t\u00e9 ghars","volume":"2","author":"A. Telli","year":"2010","journal-title":"Annales des Sciences et Technologie"},{"key":"44","doi-asserted-by":"publisher","DOI":"10.1177\/1934578x0900400419"},{"key":"45","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijantimicag.2005.09.002"},{"key":"46","doi-asserted-by":"publisher","DOI":"10.1002\/ffj.2082"},{"key":"47","doi-asserted-by":"publisher","DOI":"10.1002\/mabi.201300561"},{"key":"48","first-page":"616","article-title":"Evaluation of cutaneous wound healing activity of Malva sylvestris aqueous extract in BALB\/c mice","volume":"18","author":"M. Afshar","year":"2015","journal-title":"Iranian Journal of Basic Medical Sciences"},{"key":"49","first-page":"341","article-title":"Effect of Malva sylvestris cream on burn injury and wounds in rats","volume":"5","author":"E. Nasiri","year":"2015","journal-title":"Avicenna Journal of Phytomedicine"},{"key":"50","doi-asserted-by":"publisher","DOI":"10.1177\/0883911518792288"},{"key":"51","doi-asserted-by":"publisher","DOI":"10.1021\/jf801111c"},{"key":"52","first-page":"377","volume-title":"Biofunctionalization of Nanomaterials","author":"C. S. Kumar","year":"2005"},{"key":"53","doi-asserted-by":"publisher","DOI":"10.1002\/term.2998"},{"key":"54","doi-asserted-by":"publisher","DOI":"10.1007\/s12262-010-0169-2"},{"key":"55","doi-asserted-by":"publisher","DOI":"10.1016\/j.colsurfb.2015.08.029"},{"key":"56","doi-asserted-by":"publisher","DOI":"10.1016\/j.jep.2012.02.025"},{"key":"57","doi-asserted-by":"publisher","DOI":"10.1021\/acs.chemmater.0c02823"},{"key":"58","doi-asserted-by":"publisher","DOI":"10.1016\/j.biomaterials.2018.08.044"},{"key":"59","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-020-65268-7"},{"key":"60","doi-asserted-by":"publisher","DOI":"10.1016\/j.fct.2015.04.025"},{"key":"61","doi-asserted-by":"publisher","DOI":"10.1007\/s10853-012-7092-9"}],"container-title":["Evidence-Based Complementary and Alternative Medicine"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/downloads.hindawi.com\/journals\/ecam\/2021\/6646702.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/downloads.hindawi.com\/journals\/ecam\/2021\/6646702.xml","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/downloads.hindawi.com\/journals\/ecam\/2021\/6646702.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,5,15]],"date-time":"2021-05-15T20:20:17Z","timestamp":1621110017000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.hindawi.com\/journals\/ecam\/2021\/6646702\/"}},"subtitle":[],"editor":[{"given":"Francesca","family":"Mancianti","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"editor"}]}],"short-title":[],"issued":{"date-parts":[[2021,5,15]]},"references-count":61,"alternative-id":["6646702","6646702"],"URL":"https:\/\/doi.org\/10.1155\/2021\/6646702","relation":{},"ISSN":["1741-4288","1741-427X"],"issn-type":[{"value":"1741-4288","type":"electronic"},{"value":"1741-427X","type":"print"}],"subject":[],"published":{"date-parts":[[2021,5,15]]}}}