{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,12]],"date-time":"2026-06-12T22:58:19Z","timestamp":1781305099666,"version":"3.54.1"},"reference-count":36,"publisher":"Wiley","license":[{"start":{"date-parts":[[2021,4,5]],"date-time":"2021-04-05T00:00:00Z","timestamp":1617580800000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Toxicology"],"published-print":{"date-parts":[[2021,4,5]]},"abstract":"<jats:p>Tectona grandis (T. grandis) is a medicinal plant widely used in Cameroon to treat typhoid fever and several other diseases. Despite its heavy use for medical purposes, no study has yet been conducted to assess its potentially toxic effects. This study aimed at evaluating the acute and subchronic toxicological profile of Tectona grandis leaf extract in rats. The acute toxicity study revealed neither behavioral disturbances nor death in rats. The lethal dose (DL50) of this extract is greater than 5000\u2009mg\/kg body weight. The subchronic toxicity study showed no significant change in weight gain in rats at test doses throughout the treatment period. However, there was a significant decrease in alanine transaminase activity and serum protein levels at all doses. Alkaline phosphatase activity decreased at doses of 30, 90, and 270\u2009mg\/kg and increased at the dose of 810\u2009mg\/kg body weight. Serum and urinary urea levels increased simultaneously at doses of 270 and 810\u2009mg\/kg body weight. Repeated administration of the extract also increased total cholesterol, high-density lipoprotein levels in both sexes were compared to respective controls, and the ratio of high- to low-density lipoprotein was found to be greater than 1 in all animals. However, at the dose of 810\u2009mg\/kg, necrosis was observed on the kidney sections and vascular congestion on the liver sections of animals. Aqueous extract of T. grandis did not lead to any adverse effects in rats after acute and subchronic treatment at 30 and 90\u2009mg\/kg doses. This extract can, therefore, be used for the formulation of typhoid fever phytomedicine at the therapeutic dose of 30\u2009mg\/kg, but before this, chronic and mutagenic toxicity evaluations must be carried out.<\/jats:p>","DOI":"10.1155\/2021\/6646771","type":"journal-article","created":{"date-parts":[[2021,4,7]],"date-time":"2021-04-07T22:12:35Z","timestamp":1617833555000},"page":"1-10","source":"Crossref","is-referenced-by-count":15,"title":["Toxicological Profile of the Aqueous Extract of Tectona grandis L.F. (Verbenaceae) Leaves: A Medicinal Plant Used in the Treatment of Typhoid Fever in Traditional Cameroonian Medicine"],"prefix":"10.1155","volume":"2021","author":[{"given":"Gabriel Tchuente","family":"Kamsu","sequence":"first","affiliation":[{"name":"Department of Biochemistry, Faculty of Science, University of Dschang, P.O. Box 67, Dschang, Cameroon"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dieudonn\u00e9 Pascal","family":"Djamen Chuisseu","sequence":"additional","affiliation":[{"name":"Department of Basic Sciences, Higher Institute of Health Sciences, Universit\u00e9 des Montagnes, P.O. Box 208, Bangangt\u00e9, Cameroon"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sim\u00e9on Pierre","family":"Fodouop Chegaing","sequence":"additional","affiliation":[{"name":"Department of Biomedical Sciences, Faculty of Medicine, University of Ngaound\u00e9r\u00e9, P.O. 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