{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,2,21]],"date-time":"2025-02-21T21:54:19Z","timestamp":1740174859513,"version":"3.37.3"},"reference-count":20,"publisher":"Wiley","license":[{"start":{"date-parts":[[2021,1,21]],"date-time":"2021-01-21T00:00:00Z","timestamp":1611187200000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81774267","BK20141502"],"award-info":[{"award-number":["81774267","BK20141502"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Jiangsu Provincial Science and Technology Department Provincial Natural Fund Project","award":["81774267","BK20141502"],"award-info":[{"award-number":["81774267","BK20141502"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Scientific Programming"],"published-print":{"date-parts":[[2021,1,21]]},"abstract":"<jats:p>Network pharmacology analysis has shown that Qu Feng Xuan Bi Formula (QFXBF) is a traditional Chinese herbal medicine used to treat bronchial asthma, with demonstrated remarkable effects; however, its effects on airway inflammation and bronchial asthma alleviation remain unclear. This study aimed to explore the underlying mechanism of QFXBF by assessing toll-like receptor-9 (TLR-9) and the downstream MAPK signaling pathway as well as the immune modulation of the Th1\/Th2 balance. The results showed that the aqueous extract of QFXBF increased TLR-9 expression, regulated the downstream genes AP-1, JNK, and ERK1\/2, and reduced serum IL-5 levels in the high-dose QFXBF group; meanwhile, following QFXBF treatment, IFN-\u03b3 and TNF-\u03b1 levels were increased, indicating that the Th1\/Th2 immune balance was reversed as predicted. These findings provide a mechanism underlying QFXBF\u2019s effects, which significantly improves the treatment and management of patients with bronchial asthma and profoundly impacts medical information processing.<\/jats:p>","DOI":"10.1155\/2021\/6648834","type":"journal-article","created":{"date-parts":[[2021,1,22]],"date-time":"2021-01-22T01:51:09Z","timestamp":1611280269000},"page":"1-10","source":"Crossref","is-referenced-by-count":1,"title":["Qu Feng Xuan Bi Formula Alleviates Airway Inflammation and Guides Clinical Treatment by Improving Bronchial Immune Balance in the Asthma Model"],"prefix":"10.1155","volume":"2021","author":[{"given":"Po","family":"Hu","sequence":"first","affiliation":[{"name":"The First Clinical Medical College, Nanjing University of Traditional Chinese Medicine, Nanjing, Jiangsu 210029, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1447-7059","authenticated-orcid":true,"given":"Suofang","family":"Shi","sequence":"additional","affiliation":[{"name":"Department of Respiratory Diseases, The First Affiliation Hospital of Nanjing University of Traditional Chinese Medicine, Nanjing, Jiangsu 210029, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Li","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Molecular Biology, The First Affiliation Hospital of Nanjing University of Traditional Chinese Medicine, Nanjing, Jiangsu 210029, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shuomiao","family":"Yin","sequence":"additional","affiliation":[{"name":"The First Clinical Medical College, Guangzhou University of Traditional Chinese Medicine, Guangzhou, Guangdong 510006, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lingfu","family":"Wang","sequence":"additional","affiliation":[{"name":"The First Clinical Medical College, Nanjing University of Traditional Chinese Medicine, Nanjing, Jiangsu 210029, China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","reference":[{"key":"1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2006.02.015"},{"volume-title":"Global Surveillance, Prevention and Control of Chronic Respiratory Diseases: A Comprehensive Approach","year":"2007","author":"WHO","key":"2"},{"key":"3","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2012.12.1561"},{"key":"4","doi-asserted-by":"publisher","DOI":"10.1159\/000362553"},{"key":"5","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.g5517"},{"key":"6","doi-asserted-by":"publisher","DOI":"10.1016\/j.jep.2014.02.006"},{"key":"7","doi-asserted-by":"publisher","DOI":"10.2165\/11536140-000000000-00000"},{"issue":"1","key":"8","first-page":"1","article-title":"When ubiquitination meets phosphorylation: a systems biology perspective of EGFR\/MAPK signaling","volume":"11","author":"K. 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