{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,14]],"date-time":"2026-07-14T19:52:46Z","timestamp":1784058766079,"version":"3.55.0"},"reference-count":43,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2021,5,31]],"date-time":"2021-05-31T00:00:00Z","timestamp":1622419200000},"content-version":"vor","delay-in-days":150,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2021,1,1]],"date-time":"2021-01-01T00:00:00Z","timestamp":1609459200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"name":"NTEC DOVS"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Journal of Ophthalmology"],"published-print":{"date-parts":[[2021,1]]},"abstract":"<jats:p>\n                    <jats:italic>Objective<\/jats:italic>\n                    . To describe the morphological changes on fundus autofluorescence (FAF) and spectral\u2010domain optical coherence tomography (SD\u2010OCT) imaging at different chronicity of central serous chorioretinopathy (CSC).\n                    <jats:italic>Methods<\/jats:italic>\n                    . This cross\u2010sectional study included patients with CSC of different chronicity. Changes in FAF scans and morphological changes on SD\u2010OCT were evaluated and compared at different stages of CSC.\n                    <jats:italic>Results<\/jats:italic>\n                    . Sixty\u2010nine patients were enrolled in the study, with a mean age of 52.1\u2009\u00b1\u200911.8 years. A distinct hypoautofluorescence (AF) pattern was observed at the leakage point in acute CSC (100%). The leakage site was indistinguishable in 48% of the patients with late\u2010chronic CSC. The majority of acute CSC patients showed hyper\u2010AF in the area of serous retinal detachment (SRD), which persisted in the early\u2010chronic stage of CSC. In late\u2010chronic CSC, many cases of hypo\u2010AF (22.2%) and mixed\u2010pattern AF (14.8%) were observed. SD\u2010OCT revealed evolving features of retinal pigment epithelium (RPE) abnormalities in a time\u2010dependent manner: from peaked PEDs in acute CSC to low\u2010lying PEDs in early\u2010chronic CSC and, eventually, flat, irregular PEDs in late\u2010chronic CSC. The average thickness of the photoreceptor layer (inner and outer segment; IS\/OS) was 79\u2009\n                    <jats:italic>\u03bc<\/jats:italic>\n                    m in the acute group and 55.2\u2009\n                    <jats:italic>\u03bc<\/jats:italic>\n                    m in the chronic group. The photoreceptor layer (IS\/OS) height was positively associated with visual acuity (\n                    <jats:italic>p<\/jats:italic>\n                    = 0.002).\n                    <jats:italic>Conclusion<\/jats:italic>\n                    . Different stages of CSC present different patterns on FAF and SD\u2010OCT imaging. Chronicity of CSC can be estimated using specific features in these images. Photoreceptor layer (IS\/OS) height acts as a good and objective predictor of visual outcomes in CSC patients.\n                  <\/jats:p>","DOI":"10.1155\/2021\/6649064","type":"journal-article","created":{"date-parts":[[2021,5,31]],"date-time":"2021-05-31T21:57:56Z","timestamp":1622498276000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Fundus Autofluorescence and Optical Coherence Tomography Characteristics in Different Stages of Central Serous Chorioretinopathy"],"prefix":"10.1155","volume":"2021","author":[{"given":"Mary","family":"Ho","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stephanie H. W.","family":"Kwok","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrew C. 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