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Associated with epidemics of obesity, nonalcoholic fatty liver disease (NAFLD) is becoming the most prevalent liver disease worldwide. The cornerstone of therapy for NAFLD is lifestyle intervention, mainly focused on weight loss. Significant weight loss results from energy\u2010restricted diets, regardless of macronutrient distribution. An anti\u2010inflammatory diet was related to lower odds of NAFLD among daily alcohol drinkers and individuals with metabolic syndrome. This study aims to evaluate the effect of an energy\u2010reduced anti\u2010inflammatory diet on liver status in younger adults with obesity after a 6\u2010month follow\u2010up. <jats:italic>Methods<\/jats:italic>. A two\u2010arm randomized controlled trial surveyed 81 participants\u2019 (mean age, 43\u2009years) anthropometric and body composition changes. Metabolic status was determined with glycaemic and lipid status, inflammatory status with hs\u2010CRP, IL\u20106, and TNF\u2010<jats:italic>\u03b1<\/jats:italic>, and liver status with liver enzymes, NAFLD\u2010FLS, FLI, and FIB\u20104 indices. The inflammatory potential of the diet was assessed by the Dietary Inflammatory Index, DII\u00ae. <jats:italic>Results<\/jats:italic>. Energy\u2010restricted anti\u2010inflammatory diet resulted in significant weight loss (\u22127.1%, <jats:italic>p<\/jats:italic>\u2009&lt;\u20090.001), in reducing the visceral adiposity (\u221222.3%, <jats:italic>p<\/jats:italic>\u2009&lt;\u20090.001), metabolic (HOMA\u2010IR, \u221215.5%; total cholesterol, \u22125.3%; LDL\u2010C, \u22124.6%; triglycerides, \u221212.2%), and inflammatory biomarkers (hs\u2010CRP, \u221229.5%; IL\u20106, \u221218.2%; TNF\u2010<jats:italic>\u03b1<\/jats:italic>, \u221234.2%), with significant improvement of liver parameters (NAFLD\u2010FLS, \u2212143.4%; FLI, \u221214.3%; FIB\u20104, \u22122.5%). <jats:italic>Conclusion<\/jats:italic>. The study showed the effectiveness of the anti\u2010inflammatory diet with significant improvement of liver parameters in younger adults with obesity, which may reinforce the effectiveness of nutrition\u2010based lifestyle programs, with an anti\u2010inflammatory dietary approach for the treatment and resolution of NAFLD.<\/jats:p>","DOI":"10.1155\/2021\/6649142","type":"journal-article","created":{"date-parts":[[2021,2,9]],"date-time":"2021-02-09T20:48:49Z","timestamp":1612903729000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":17,"title":["Metabolic and Hepatic Effects of Energy\u2010Reduced Anti\u2010Inflammatory Diet in Younger Adults with Obesity"],"prefix":"10.1155","volume":"2021","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8694-8761","authenticated-orcid":false,"given":"Gordana","family":"Ken\u0111el Jovanovi\u0107","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0679-2849","authenticated-orcid":false,"given":"Ines","family":"Mrakovcic-Sutic","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7943-0617","authenticated-orcid":false,"given":"Sandra","family":"Pavi\u010di\u0107 \u017de\u017eelj","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9740-3310","authenticated-orcid":false,"given":"Indira","family":"Benjak Horvat","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lucia","family":"\u0160u\u0161a","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2901-0646","authenticated-orcid":false,"given":"Dario","family":"Raheli\u0107","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0287-4735","authenticated-orcid":false,"given":"Sanja","family":"Klobu\u010dar Majanovi\u0107","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2021,2,9]]},"reference":[{"key":"e_1_2_10_1_2","doi-asserted-by":"publisher","DOI":"10.3748\/wjg.v20.i37.13306"},{"key":"e_1_2_10_2_2","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2008.01.075"},{"key":"e_1_2_10_3_2","doi-asserted-by":"publisher","DOI":"10.1152\/ajpendo.00064.2004"},{"key":"e_1_2_10_4_2","doi-asserted-by":"publisher","DOI":"10.3390\/ijms17050717"},{"key":"e_1_2_10_5_2","doi-asserted-by":"publisher","DOI":"10.1155\/2020\/9181368"},{"key":"e_1_2_10_6_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhep.2011.06.010"},{"key":"e_1_2_10_7_2","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2009.01.048"},{"key":"e_1_2_10_8_2","doi-asserted-by":"publisher","DOI":"10.1097\/mog.0b013e3283358a58"},{"key":"e_1_2_10_9_2","doi-asserted-by":"publisher","DOI":"10.3390\/nu11030544"},{"key":"e_1_2_10_10_2","doi-asserted-by":"publisher","DOI":"10.1002\/hep.29367"},{"key":"e_1_2_10_11_2","doi-asserted-by":"publisher","DOI":"10.1111\/liv.13311"},{"key":"e_1_2_10_12_2","doi-asserted-by":"publisher","DOI":"10.3390\/nu11102543"},{"key":"e_1_2_10_13_2","doi-asserted-by":"publisher","DOI":"10.3390\/nu9080800"},{"key":"e_1_2_10_14_2","doi-asserted-by":"publisher","DOI":"10.1017\/s000711451800137x"},{"key":"e_1_2_10_15_2","doi-asserted-by":"publisher","DOI":"10.1024\/0300-9831\/a000571"},{"key":"e_1_2_10_16_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.clnu.2017.06.027"},{"key":"e_1_2_10_17_2","doi-asserted-by":"publisher","DOI":"10.1177\/1756284819858039"},{"key":"e_1_2_10_18_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.eujim.2020.101165"},{"key":"e_1_2_10_19_2","article-title":"Odluka o standardu prehrane bolesnika u bolnicama","volume":"59","author":"zdravlja M.","year":"2015","journal-title":"Narodne Novine"},{"key":"e_1_2_10_20_2","doi-asserted-by":"publisher","DOI":"10.1093\/ajcn\/51.2.241"},{"key":"e_1_2_10_21_2","doi-asserted-by":"publisher","DOI":"10.1079\/phn2002439"},{"key":"e_1_2_10_22_2","doi-asserted-by":"publisher","DOI":"10.1111\/jhn.12695"},{"key":"e_1_2_10_23_2","volume-title":"Tablice O Sastavu Namirnica I Pica","author":"Kai\u0107-Rak A.","year":"1990"},{"key":"e_1_2_10_24_2","unstructured":"Frida Food Data Ver. 1 National Food Institute Technical University of Denmark 2015 http:\/\/frida.fooddata.dk."},{"key":"e_1_2_10_25_2","volume-title":"Agricultural Research Service","author":"U.S. Department of Agriculture"},{"key":"e_1_2_10_26_2","volume-title":"Phenol-Explorer 3.0: A Major Update of the Phenol-Explorer Database to Incorporate Data on the Effects of Food Processing on Polyphenol Content","author":"Rothwell J. 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