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Historically, it was known as a marine medicinal herb to treat hemorrhoids and cholera morbus in Donguibogam. We investigated the effects of P. tenera extract (PTE) for its antioxidant and anti-inflammatory activities. These activities were measured using assays for 2,2-diphenyl-1-picrylhydrazyl (DPPH) and nitric oxide (NO) radical scavenging and its superoxide dismutase- (SOD-) like activity, and through the inhibitory production of inflammatory mediators (prostaglandin E2 (PGE2), NO, tumor necrosis factor alpha (TNF-\u03b1), and interleukin-6 (IL-6)) in lipopolysaccharide- (LPS-) stimulated Raw 264.7 cells. The antioxidant assay results showed that PTE displayed DPPH radical scavenging activity (46.44%), NO radical scavenging activity (67.14%), and SOD-like activity (80.29%) at a concentration of 5\u2009mg\/mL. In the anti-inflammatory assays, treatment with PTE (1\u2009mg\/mL) significantly inhibited expression levels of LPS-induced COX-2 and iNOS, as well as the production of PGE2, NO, TNF-\u03b1, and IL-6. These results show that PTE has antioxidant and anti-inflammatory properties and provide scientific evidence to explain the antioxidative and anti-inflammatory properties of PTE.<\/jats:p>","DOI":"10.1155\/2021\/6650037","type":"journal-article","created":{"date-parts":[[2021,4,2]],"date-time":"2021-04-02T23:05:05Z","timestamp":1617404705000},"page":"1-10","source":"Crossref","is-referenced-by-count":8,"title":["Inhibitory Effects of Porphyra tenera Extract on Oxidation and Inflammatory Responses"],"prefix":"10.1155","volume":"2021","author":[{"given":"Chul Won","family":"Lee","sequence":"first","affiliation":[{"name":"Research Institute for Korean Medicine, Pusan National University, Yangsan 50612, Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yong-Tae","family":"Ahn","sequence":"additional","affiliation":[{"name":"Research Institute for Korean Medicine, Pusan National University, Yangsan 50612, Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rongjie","family":"Zhao","sequence":"additional","affiliation":[{"name":"Department of Psychopharmacology, Qiqihar Medical University, Qiqihar 161006, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Youn Sook","family":"Kim","sequence":"additional","affiliation":[{"name":"School of Medicine, Pusan National University, Yangsan 50612, Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sang Mi","family":"Park","sequence":"additional","affiliation":[{"name":"College of Korean Medicine, Daegu Haany University, Gyeongsan 38610, Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dae Hwa","family":"Jung","sequence":"additional","affiliation":[{"name":"College of Korean Medicine, Daegu Haany University, Gyeongsan 38610, Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jae Kwang","family":"Kim","sequence":"additional","affiliation":[{"name":"Korean Medicine-Application Center, Korea Institute of Oriental Medicine, Daegu 41062, Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hyung Woo","family":"Kim","sequence":"additional","affiliation":[{"name":"Division of Pharmacology, School of Korean Medicine, Pusan National University, Yangsan 50612, Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0515-0764","authenticated-orcid":true,"given":"Sang Chan","family":"Kim","sequence":"additional","affiliation":[{"name":"College of Korean Medicine, Daegu Haany University, Gyeongsan 38610, Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1341-2114","authenticated-orcid":true,"given":"Won G.","family":"An","sequence":"additional","affiliation":[{"name":"Division of Pharmacology, School of Korean Medicine, Pusan National University, Yangsan 50612, Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","reference":[{"issue":"4","key":"1","first-page":"469","article-title":"Nitric oxide and superoxide in inflammation and immune regulation","volume":"54","author":"T. 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