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Interleukin\u201010 (IL\u201010) has been suggested as a biomarker of disease activity in patients with adult\u2010onset Still\u2019s disease (AOSD). In this study, we evaluated the serum IL\u201010 levels and investigated its clinical relevance in systemic\u2010onset juvenile idiopathic arthritis (SoJIA). <jats:italic>Methods<\/jats:italic>. IL\u201010 levels were determined in 21 patients diagnosed with SoJIA and 35 patients with fever diseases which were suspected as SoJIA, and IL\u201010 levels were compared between SoJIA patients with regard to disease activity, disease courses, and other biomarkers. <jats:italic>Results<\/jats:italic>. Patients with SoJIA had significantly higher levels of IL\u201010 compared to patients with other febrile diseases. The serum levels of IL\u201010 were significantly higher in active SoJIA compared to inactive and positively correlated with known disease activity markers such as erythrocyte sedimentation rate (ESR), C\u2010reactive protein level (CRP), ferritin (FER), and IL\u20106 levels. Moreover, the levels of IL\u201010 at diagnosis were significantly higher in SoJIA patients with a nonmonocyclic pattern than in patients with a monocyclic pattern. Compared to CRP, ESR, FER, and IL\u20106, IL\u201010 levels were superior in predicting monocyclic patients from nonmonocyclic patients. <jats:italic>Conclusion<\/jats:italic>. Compared to other febrile diseases, SoJIA patients have markedly higher levels of IL\u201010 which may assist with diagnosis. And a clear association of serum IL\u201010 levels with disease activity and disease courses in SoJIA was found. These results suggest that serum IL\u201010 might be a reliable clinical marker in SoJIA.<\/jats:p>","DOI":"10.1155\/2021\/6650928","type":"journal-article","created":{"date-parts":[[2021,3,22]],"date-time":"2021-03-22T20:20:07Z","timestamp":1616444407000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":12,"title":["The Association of Serum IL\u201010 Levels with the Disease Activity in Systemic\u2010Onset Juvenile Idiopathic Arthritis Patients"],"prefix":"10.1155","volume":"2021","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4623-8829","authenticated-orcid":false,"given":"Yu","family":"Peng","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiaohui","family":"Liu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zhao","family":"Duan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6515-6626","authenticated-orcid":false,"given":"Junkai","family":"Duan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6698-5290","authenticated-orcid":false,"given":"Yulan","family":"Zhou","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2021,3,22]]},"reference":[{"key":"e_1_2_9_1_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.autrev.2016.07.004"},{"key":"e_1_2_9_2_2","doi-asserted-by":"publisher","DOI":"10.1007\/s10067-018-4297-6"},{"key":"e_1_2_9_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaut.2018.07.018"},{"key":"e_1_2_9_4_2","doi-asserted-by":"publisher","DOI":"10.53738\/REVMED.2018.14.594.0372"},{"key":"e_1_2_9_5_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.smim.2019.101344"},{"key":"e_1_2_9_6_2","doi-asserted-by":"publisher","DOI":"10.1007\/978-981-13-9367-9_4"},{"key":"e_1_2_9_7_2","doi-asserted-by":"publisher","DOI":"10.3390\/ijms20236008"},{"key":"e_1_2_9_8_2","doi-asserted-by":"publisher","DOI":"10.1146\/annurev-immunol-031210-101312"},{"key":"e_1_2_9_9_2","doi-asserted-by":"publisher","DOI":"10.1101\/cshperspect.a028548"},{"key":"e_1_2_9_10_2","doi-asserted-by":"publisher","DOI":"10.1007\/s10067-019-04642-x"},{"key":"e_1_2_9_11_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00296-002-0191-1"},{"key":"e_1_2_9_12_2","first-page":"1241","article-title":"Serum cytokine levels in children with newly diagnosed active systemic juvenile idiopathic arthritis","volume":"16","author":"Guo L.","year":"2014","journal-title":"Chinese journal of contemporary pediatrics"},{"key":"e_1_2_9_13_2","first-page":"390","article-title":"International League of Associations for Rheumatology classification of juvenile idiopathic arthritis: second revision, Edmonton, 2001","volume":"31","author":"Petty R. 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