{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,20]],"date-time":"2026-05-20T02:04:12Z","timestamp":1779242652798,"version":"3.51.4"},"reference-count":31,"publisher":"Wiley","license":[{"start":{"date-parts":[[2021,5,12]],"date-time":"2021-05-12T00:00:00Z","timestamp":1620777600000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100003605","name":"Korea International Cooperation Agency","doi-asserted-by":"publisher","award":["2018-0119"],"award-info":[{"award-number":["2018-0119"]}],"id":[{"id":"10.13039\/501100003605","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Korea Disease Control and Prevention Agency","award":["2018-0119"],"award-info":[{"award-number":["2018-0119"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Canadian Journal of Infectious Diseases and Medical Microbiology"],"published-print":{"date-parts":[[2021,5,12]]},"abstract":"<jats:p>The detection of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) in upper and lower respiratory specimens and coinfection with other respiratory pathogens in patients with coronavirus disease 2019 (COVID-19) was investigated. Study subjects (N\u2009=\u2009342) were retrospectively enrolled after being confirmed as SARS-CoV-2 positive, and their nasopharyngeal swab (NPS), oropharyngeal swab (OPS), and sputum specimens were restored for SARS-CoV-2 retesting and respiratory pathogen detection. The majority of the subjects (96.5%, N\u2009=\u2009330) were confirmed as SARS-CoV-2 positive using NPS\/OPS specimens. Among the COVID-19 patients (N\u2009=\u2009342), 7.9% (N\u2009=\u200927) and 0.9% (N\u2009=\u20093) were coinfected with respiratory viruses and Mycoplasma pneumoniae, respectively, yielding an 8.8% (N\u2009=\u200930) overall respiratory pathogen coinfection rate. Of the respiratory virus coinfection cases (N\u2009=\u200927), 92.6% (N\u2009=\u200925) were coinfected with a single respiratory virus and 7.4% (N\u2009=\u20092) with two viruses (metapneumovirus\/adenovirus and rhinovirus\/bocavirus). No triple coinfections of other respiratory viruses or bacteria with SARS-CoV-2 were detected. Respiratory viruses coinfected in the patients with COVID-19 were as follows: rhinovirus (N\u2009=\u20097, 2.1%), respiratory syncytial virus A and B (N\u2009=\u20096, 1.8%), non-SARS-CoV-2 coronaviruses (229E, NL63, and OC43, N\u2009=\u20095, 1.5%), metapneumovirus (N\u2009=\u20094, 1.2%), influenza A (N\u2009=\u20093, 0.9%), adenovirus (N\u2009=\u20093, 0.9%), and bocavirus (N\u2009=\u20091, 0.3%). In conclusion, the diagnostic value of utilizing NPS\/OPS specimens is excellent, and, as the first report in Korea, coinfection with respiratory pathogens was detected at a rate of 8.8% in patients with COVID-19.<\/jats:p>","DOI":"10.1155\/2021\/6651045","type":"journal-article","created":{"date-parts":[[2021,5,18]],"date-time":"2021-05-18T14:05:05Z","timestamp":1621346705000},"page":"1-9","source":"Crossref","is-referenced-by-count":19,"title":["Coinfections with Respiratory Pathogens among COVID-19 Patients in Korea"],"prefix":"10.1155","volume":"2021","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6291-9229","authenticated-orcid":true,"given":"Kyoung Ho","family":"Roh","sequence":"first","affiliation":[{"name":"Clinical Research Institute\/Molecular Diagnosis Center, Seegene Medical Foundation, Seoul 04805, Republic of Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4699-8502","authenticated-orcid":true,"given":"Yu Kyung","family":"Kim","sequence":"additional","affiliation":[{"name":"Department of Clinical Pathology, School of Medicine, Kyungpook National University Hospital, Daegu 41944, Republic of Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3755-8249","authenticated-orcid":true,"given":"Shin-Woo","family":"Kim","sequence":"additional","affiliation":[{"name":"Division of Infectious Disease, Department of Internal Medicine, Kyungpook National University Hospital, Daegu 41944, Republic of Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1677-9883","authenticated-orcid":true,"given":"Eun-Rim","family":"Kang","sequence":"additional","affiliation":[{"name":"Clinical Research Institute\/Molecular Diagnosis Center, Seegene Medical Foundation, Seoul 04805, Republic of Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6153-9646","authenticated-orcid":true,"given":"Yong-Jin","family":"Yang","sequence":"additional","affiliation":[{"name":"Clinical Research Institute\/Molecular Diagnosis Center, Seegene Medical Foundation, Seoul 04805, Republic of Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1450-8150","authenticated-orcid":true,"given":"Sun-Kyung","family":"Jung","sequence":"additional","affiliation":[{"name":"Clinical Research Institute\/Molecular Diagnosis Center, Seegene Medical Foundation, Seoul 04805, Republic of Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6393-4500","authenticated-orcid":true,"given":"Sun-Hwa","family":"Lee","sequence":"additional","affiliation":[{"name":"Clinical Research Institute\/Molecular Diagnosis Center, Seegene Medical Foundation, Seoul 04805, Republic of Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8951-163X","authenticated-orcid":true,"given":"Nackmoon","family":"Sung","sequence":"additional","affiliation":[{"name":"Clinical Research Institute\/Molecular Diagnosis Center, Seegene Medical Foundation, Seoul 04805, Republic of Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","reference":[{"key":"1","volume-title":"Coronavirus Disease (COVID-19) Weekly Epidemiological Update; 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