{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,27]],"date-time":"2026-01-27T21:26:24Z","timestamp":1769549184590,"version":"3.49.0"},"reference-count":29,"publisher":"Wiley","license":[{"start":{"date-parts":[[2021,3,8]],"date-time":"2021-03-08T00:00:00Z","timestamp":1615161600000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Computational and Mathematical Methods in Medicine"],"published-print":{"date-parts":[[2021,3,8]]},"abstract":"<jats:p>The lipolysis-stimulated lipoprotein receptor (LSR) displays an important regulatory role in cancer. However, the association between LSR and lung cancer is still elusive. Here, the candidate oncogene LSR on Ch.9q was obtained and assessed by bioinformatics analysis of The Cancer Genome Atlas (TCGA) dataset of lung cancer. We conducted clinical pathology and survival analysis based on the lung cancer database. We assessed the biological effects of LSR in lung cancer cells on cell proliferation. Our data indicated that LSR was upregulated in lung cancer cells. Meanwhile, LSR was identified in this study to be a poor prognostic factor, and its high expression exhibited relations with grades, stages, and nodal metastasis status. Using in vitro analysis, our data revealed that LSR could promote lung cancer progression by regulating cell proliferation, migration, and invasion. In our study, our data demonstrated that LSR was a tumor promoter for lung cancer and was a potential biomarker and target for lung cancer prognosis and treatment.<\/jats:p>","DOI":"10.1155\/2021\/6651907","type":"journal-article","created":{"date-parts":[[2021,3,9]],"date-time":"2021-03-09T19:20:09Z","timestamp":1615317609000},"page":"1-8","source":"Crossref","is-referenced-by-count":8,"title":["LSR Promotes Cell Proliferation and Invasion in Lung Cancer"],"prefix":"10.1155","volume":"2021","author":[{"given":"Min","family":"Zhang","sequence":"first","affiliation":[{"name":"Department of Respiratory Medicine, The Second Affiliated Hospital of Zhejiang University School of Medicine, 88 Jiefang Road, 310009 Hangzhou, Zhejiang, China"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5603-5964","authenticated-orcid":true,"given":"Cui","family":"Ma","sequence":"additional","affiliation":[{"name":"Department of Endocrinology, Zhejiang Greentown Cardiovascular Hospital, 409 Gudun Road, 310012 Hangzhou, Zhejiang, China"}]}],"member":"311","reference":[{"key":"1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijrobp.2011.01.069"},{"key":"2","doi-asserted-by":"publisher","DOI":"10.1016\/j.clnu.2005.05.001"},{"key":"3","doi-asserted-by":"publisher","DOI":"10.1016\/j.ccm.2011.09.001"},{"key":"4","doi-asserted-by":"publisher","DOI":"10.1378\/chest.112.4_Supplement.251S"},{"key":"5","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2005.11.138"},{"key":"6","doi-asserted-by":"publisher","DOI":"10.1016\/j.neurobiolaging.2018.04.013"},{"key":"7","doi-asserted-by":"publisher","DOI":"10.1016\/j.pathol.2018.11.002"},{"key":"8","doi-asserted-by":"publisher","DOI":"10.1111\/j.1432-1033.2004.04223.x"},{"key":"9","doi-asserted-by":"publisher","DOI":"10.1111\/cge.13181"},{"key":"10","doi-asserted-by":"publisher","DOI":"10.1242\/jcs.072058"},{"key":"11","doi-asserted-by":"publisher","DOI":"10.1007\/s00418-019-01821-4"},{"key":"12","doi-asserted-by":"publisher","DOI":"10.1186\/1755-8794-1-31"},{"key":"13","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-2275(20)34932-4"},{"key":"14","doi-asserted-by":"publisher","DOI":"10.18632\/oncotarget.10425"},{"key":"15","doi-asserted-by":"publisher","DOI":"10.18632\/oncotarget.25952"},{"key":"16","doi-asserted-by":"publisher","DOI":"10.1158\/1541-7786.MCR-16-0085-T"},{"key":"17","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2004.06.006"},{"key":"18","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0091747"},{"key":"19","doi-asserted-by":"publisher","DOI":"10.1158\/1078-0432.CCR-07-0882"},{"key":"20","doi-asserted-by":"publisher","DOI":"10.18632\/oncotarget.8408"},{"key":"21","doi-asserted-by":"publisher","DOI":"10.1245\/s10434-013-3325-7"},{"key":"22","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0045825"},{"key":"23","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbamcr.2011.03.010"},{"key":"24","doi-asserted-by":"publisher","DOI":"10.1007\/s00018-015-2112-y"},{"key":"25","doi-asserted-by":"publisher","DOI":"10.1517\/14728222.2011.648617"},{"key":"26","doi-asserted-by":"publisher","DOI":"10.1101\/gad.1211604"},{"key":"27","doi-asserted-by":"publisher","DOI":"10.1038\/nrm.2017.98"},{"key":"28","doi-asserted-by":"publisher","DOI":"10.1093\/carcin\/bgw098"},{"key":"29","doi-asserted-by":"publisher","DOI":"10.1111\/j.1582-4934.2008.00455.x"}],"container-title":["Computational and Mathematical Methods in Medicine"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/downloads.hindawi.com\/journals\/cmmm\/2021\/6651907.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/downloads.hindawi.com\/journals\/cmmm\/2021\/6651907.xml","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/downloads.hindawi.com\/journals\/cmmm\/2021\/6651907.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,3,9]],"date-time":"2021-03-09T19:20:11Z","timestamp":1615317611000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.hindawi.com\/journals\/cmmm\/2021\/6651907\/"}},"subtitle":[],"editor":[{"given":"Tao","family":"Huang","sequence":"additional","affiliation":[]}],"short-title":[],"issued":{"date-parts":[[2021,3,8]]},"references-count":29,"alternative-id":["6651907","6651907"],"URL":"https:\/\/doi.org\/10.1155\/2021\/6651907","relation":{},"ISSN":["1748-6718","1748-670X"],"issn-type":[{"value":"1748-6718","type":"electronic"},{"value":"1748-670X","type":"print"}],"subject":[],"published":{"date-parts":[[2021,3,8]]}}}