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The ubiquitous distributions of H<jats:sub>2<\/jats:sub>S\u2010producing enzymes and potent chemical reactivities of H<jats:sub>2<\/jats:sub>S in biological systems make H<jats:sub>2<\/jats:sub>S unique in its ability to regulate cellular and organ functions in both health and disease. Acting as an antioxidant, H<jats:sub>2<\/jats:sub>S can combat oxidative species such as reactive oxygen species (ROS) and reactive nitrogen species (RNS) and protect the skin from oxidative stress. The aberrant metabolism of H<jats:sub>2<\/jats:sub>S is involved in the pathogenesis of several skin diseases, such as vascular disorders, psoriasis, ulcers, pigment disorders, and melanoma. Furthermore, H<jats:sub>2<\/jats:sub>S donors and some H<jats:sub>2<\/jats:sub>S hybrids have been evaluated in many experimental models of human disease and have shown promising therapeutic results. In this review, we discuss recent advances in understanding H<jats:sub>2<\/jats:sub>S and its antioxidant effects on skin pathology, the roles of altered H<jats:sub>2<\/jats:sub>S metabolism in skin disorders, and the potential value of H<jats:sub>2<\/jats:sub>S as a therapeutic intervention in skin diseases.<\/jats:p>","DOI":"10.1155\/2021\/6652086","type":"journal-article","created":{"date-parts":[[2021,4,21]],"date-time":"2021-04-21T03:03:43Z","timestamp":1618974223000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":33,"title":["Hydrogen Sulfide in Skin Diseases: A Novel Mediator and Therapeutic 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