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Hyperhomocysteinemia (HHct) is caused by numerous factors, such as genetic defects, lack of folic acid, vitamin B<jats:sub>6<\/jats:sub> and B<jats:sub>12<\/jats:sub> deficiency, hypothyroidism, drugs, aging, and renal dysfunction. Increased Hct in peripheral blood may lead to vascular illnesses, coronary artery dysfunction, atherosclerotic changes, and embolic diseases. Compared to nonpregnant women, the Hct level is lower in normal pregnancies. Recent studies have reported that HHct was associated with numerous pregnancy complications, including recurrent pregnancy loss (RPL), preeclampsia (PE), preterm delivery, placental abruption, fetal growth restriction (FGR), and gestational diabetes mellitus (GDM). Besides, it was discovered that neonatal birth weight and maternal Hct levels were negatively correlated. However, a number of these findings lack consistency. In this review, we summarized the metabolic process of Hct in the human body, the levels of Hct in different stages of normal pregnancy reported in previous studies, and the relationship between Hct and pregnancy complications. The work done is helpful for obstetricians to improve the likelihood of a positive outcome during pregnancy complications. Reducing the Hct level with a high dosage of folic acid supplements during the next pregnancy could be helpful for females who have suffered pregnancy complications due to HHct.<\/jats:p>","DOI":"10.1155\/2021\/6652231","type":"journal-article","created":{"date-parts":[[2021,5,7]],"date-time":"2021-05-07T18:06:50Z","timestamp":1620410810000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":123,"title":["A Novel Review of Homocysteine and Pregnancy Complications"],"prefix":"10.1155","volume":"2021","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6183-0882","authenticated-orcid":false,"given":"Chuce","family":"Dai","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9844-6777","authenticated-orcid":false,"given":"Yiming","family":"Fei","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8277-0137","authenticated-orcid":false,"given":"Jianming","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1390-1217","authenticated-orcid":false,"given":"Yang","family":"Shi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4949-131X","authenticated-orcid":false,"given":"Xiuhua","family":"Yang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2021,5,7]]},"reference":[{"key":"e_1_2_12_1_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.261469998"},{"key":"e_1_2_12_2_2","first-page":"237","article-title":"MTHFR genetic testing: controversy and clinical implications","volume":"45","author":"Long S.","year":"2016","journal-title":"Australian Family Physician"},{"key":"e_1_2_12_3_2","doi-asserted-by":"publisher","DOI":"10.1097\/MBC.0b013e328344f80f"},{"key":"e_1_2_12_4_2","doi-asserted-by":"publisher","DOI":"10.1079\/BJN2000302"},{"key":"e_1_2_12_5_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.febslet.2009.03.038"},{"key":"e_1_2_12_6_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.nut.2007.01.002"},{"key":"e_1_2_12_7_2","doi-asserted-by":"publisher","DOI":"10.1016\/0741-5214(94)90230-5"},{"key":"e_1_2_12_8_2","doi-asserted-by":"publisher","DOI":"10.1001\/jama.1997.03540460039030"},{"key":"e_1_2_12_9_2","doi-asserted-by":"publisher","DOI":"10.1001\/jama.1992.03490070059042"},{"key":"e_1_2_12_10_2","doi-asserted-by":"publisher","DOI":"10.1001\/jama.1995.03530130055028"},{"key":"e_1_2_12_11_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199603213341203"},{"key":"e_1_2_12_12_2","doi-asserted-by":"publisher","DOI":"10.1055\/s-0038-1655990"},{"key":"e_1_2_12_13_2","doi-asserted-by":"publisher","DOI":"10.1055\/s-2000-8472"},{"key":"e_1_2_12_14_2","doi-asserted-by":"publisher","DOI":"10.1079\/BJN2000209"},{"key":"e_1_2_12_15_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-9378(99)70269-3"},{"key":"e_1_2_12_16_2","doi-asserted-by":"publisher","DOI":"10.1067\/mob.2000.109044"},{"key":"e_1_2_12_17_2","doi-asserted-by":"publisher","DOI":"10.1038\/sj.ejcn.1601236"},{"key":"e_1_2_12_18_2","doi-asserted-by":"publisher","DOI":"10.1093\/ajcn\/76.3.614"},{"key":"e_1_2_12_19_2","doi-asserted-by":"publisher","DOI":"10.1067\/S0002-9378(03)00669-0"},{"key":"e_1_2_12_20_2","doi-asserted-by":"publisher","DOI":"10.1093\/ajcn\/81.6.1383"},{"key":"e_1_2_12_21_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.0902-4441.2006.t01-1-EJH2550.x"},{"key":"e_1_2_12_22_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0609.2007.00873.x"},{"key":"e_1_2_12_23_2","doi-asserted-by":"publisher","DOI":"10.1093\/ajcn\/87.2.391"},{"key":"e_1_2_12_24_2","doi-asserted-by":"publisher","DOI":"10.3945\/jn.109.117424"},{"key":"e_1_2_12_25_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajog.2010.01.045"},{"key":"e_1_2_12_26_2","doi-asserted-by":"publisher","DOI":"10.1159\/000345589"},{"key":"e_1_2_12_27_2","doi-asserted-by":"publisher","DOI":"10.3390\/nu8120797"},{"key":"e_1_2_12_28_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00404-017-4457-y"},{"key":"e_1_2_12_29_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.cca.2018.11.026"},{"key":"e_1_2_12_30_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1538-7836.2011.04553.x"},{"key":"e_1_2_12_31_2","first-page":"129","article-title":"Homocysteine altered ROS generation and NO accumulation in endothelial cells","volume":"46","author":"Tsen C. 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