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Acute pancreatitis (AP) is a common acute abdomen inflammation, characterized by the dysregulation of digestive enzyme production and secretion. Many studies have shown that Da Cheng Qi Decoction (DCQD) is a secure, effective prescription on AP. In this study, cerulein-stimulated AR42J\u2009cells damage model was established to further explore the feasibility and underlying mechanism of DCQD as a potential inhibitor of JAK2\/STAT3 pathway for the treatment of AP. Methods. Cell viability of DCQD was measured using a cell counting Kit-8 assay. Pancreatic biochemical markers such as amylase, lipase, and C-reactive protein production were measured by assay kits, respectively. Cytokines (TNF-\u03b1, IL-6, IL-10, and IL-1\u03b2) were assayed by ELISA. Protein location and protein expression were detected by immunofluorescence staining and Western blotting, respectively. Gene expression was assessed by real-time PCR. For mechanistic analysis of the effect of DCQD on JAK2\/STAT3 signaling pathway, selective JAK2 inhibitor (Fedratinib) and STAT3 inhibitor (Stattic) as well as STAT3 activator (Garcinone D) were used. Results. DCQD protected cells by regulating cerulein-induced inflammation and reducing the secretion of pancreatic biochemical markers. Moreover, DCQD could not only inhibit the nuclear translocation of p-STAT3, but also decrease the mRNA expression of JAK2 and STAT3 as well as the ratio of p-JAK2\/JAK2 and p-STAT3\/STAT3 in protein level. Additionally, DCQD could regulate the mRNA and protein expression of JAK2\/STAT3 downstream effectors, Bax and Bcl-XL. The activated effect of cerulein on JAK2\/STAT3 pathway was also reversed by JAK2 inhibitor Fedratinib or STAT3 inhibitor Stattic. And the overexpression of JAK2\/STAT3 pathway, via STAT3 activator Garcinone D, did exert damage on cells, which bore a resemblance to cerulein. Conclusion. The activation of JAK2\/STAT3 pathway may play a key role in the pathogenesis of cerulein-stimulated AR42J pancreatic acinar cell injury. DCQD could improve inflammatory cytokines and cell injury, which might be mediated by suppressing the activation of JAK2\/STAT3 signaling pathway.<\/jats:p>","DOI":"10.1155\/2021\/6657036","type":"journal-article","created":{"date-parts":[[2021,4,10]],"date-time":"2021-04-10T17:50:11Z","timestamp":1618077011000},"page":"1-13","source":"Crossref","is-referenced-by-count":5,"title":["Da Cheng Qi Decoction Alleviates Cerulein-Stimulated AR42J Pancreatic Acinar Cell Injury via the JAK2\/STAT3 Signaling Pathway"],"prefix":"10.1155","volume":"2021","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6807-7424","authenticated-orcid":true,"given":"Zehua","family":"Zhou","sequence":"first","affiliation":[{"name":"Shanghai University of Traditional Chinese Medicine, Shanghai 201203, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9290-2391","authenticated-orcid":true,"given":"Ying","family":"Chen","sequence":"additional","affiliation":[{"name":"Shanghai University of Traditional Chinese Medicine, Shanghai 201203, China"},{"name":"Shanghai Traditional Chinese Medicine Integrated Hospital, Shanghai University of Traditional Chinese Medicine, Shanghai 200082, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9135-6974","authenticated-orcid":true,"given":"Wenmin","family":"Dong","sequence":"additional","affiliation":[{"name":"Shanghai University of Traditional Chinese Medicine, Shanghai 201203, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2080-3081","authenticated-orcid":true,"given":"Rui","family":"An","sequence":"additional","affiliation":[{"name":"Shanghai University of Traditional Chinese Medicine, Shanghai 201203, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6834-4083","authenticated-orcid":true,"given":"Kun","family":"Liang","sequence":"additional","affiliation":[{"name":"Shanghai University of Traditional Chinese Medicine, Shanghai 201203, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2687-9001","authenticated-orcid":true,"given":"Xinhong","family":"Wang","sequence":"additional","affiliation":[{"name":"Shanghai University of Traditional Chinese Medicine, Shanghai 201203, China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","reference":[{"key":"1","doi-asserted-by":"crossref","first-page":"2042","DOI":"10.2741\/3362","article-title":"Acute pancreatitis as a model of SIRS","volume":"14","author":"M. 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