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Acupuncture improves endometrial receptivity and promotes the formation of pinopodes, the ultrastructure marker implantation window. However, the specific underlying mechanisms remain unclear. In this study, the efficacy of acupuncture treatment and its underlying mechanism were investigated by analyzing pregnancy rate, pinopode formation, and related molecular markers in thin endometrium model rats. Absolute ethanol (95%) was injected into the uteruses of female Sprague\u2010Dawley rats to construct a thin endometrium model. In this model, acupuncture stimulation at EX\u2010CA1, SP6, and CV4 ameliorated the pregnancy rate. Significantly increased embryo implantation, endometrial thickness, numbers of glands, and blood vessels were observed in the electroacupuncture (EA) group compared to the model group. The number of pinopodes in the EA group was abundant, with a shape similar to that of the control group. Additionally, significantly higher expression levels of pinopode\u2010related markers, including integrin\n                    <jats:italic>\u03b1<\/jats:italic>\n                    v\n                    <jats:italic>\u03b2<\/jats:italic>\n                    3, homeobox A10 (HOXA10), heparin\u2010binding EGF\u2010like growth factor (HBEGF), estrogen receptor alpha (ER\n                    <jats:italic>\u03b1<\/jats:italic>\n                    ), and progesterone receptor (PR), were observed in the EA group than those in the model group. In conclusion, EA had a positive effect on the endometrial receptivity of thin endometrium model rats by improving pinopode formation through multiple molecular targets.\n                  <\/jats:p>","DOI":"10.1155\/2021\/6658321","type":"journal-article","created":{"date-parts":[[2021,4,15]],"date-time":"2021-04-15T14:38:14Z","timestamp":1618497494000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":27,"title":["Electroacupuncture Improves Pregnancy Outcomes in Rats with Thin Endometrium by Promoting the Expression of Pinopode\u2010Related Molecules"],"prefix":"10.1155","volume":"2021","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2533-9321","authenticated-orcid":false,"given":"Jin","family":"Xi","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7568-8669","authenticated-orcid":false,"given":"Jie","family":"Cheng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6781-7750","authenticated-orcid":false,"given":"Chun-chun","family":"Jin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0268-590X","authenticated-orcid":false,"given":"Jing-yu","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9435-3699","authenticated-orcid":false,"given":"Zhen-ru","family":"Shen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6594-8260","authenticated-orcid":false,"given":"Liang-jun","family":"Xia","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8814-6180","authenticated-orcid":false,"given":"Qian","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0680-3333","authenticated-orcid":false,"given":"Jie","family":"Shen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0408-2045","authenticated-orcid":false,"given":"You-bing","family":"Xia","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4006-3009","authenticated-orcid":false,"given":"Bin","family":"Xu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2021,4,15]]},"reference":[{"key":"e_1_2_11_1_2","doi-asserted-by":"publisher","DOI":"10.1186\/s40738-018-0050-8"},{"key":"e_1_2_11_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/S1472-6483(10)60428-2"},{"key":"e_1_2_11_3_2","doi-asserted-by":"publisher","DOI":"10.4103\/jhrs.JHRS_9_17"},{"key":"e_1_2_11_4_2","doi-asserted-by":"publisher","DOI":"10.1093\/humupd\/dmu011"},{"key":"e_1_2_11_5_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.rbmo.2017.12.016"},{"key":"e_1_2_11_6_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.rbmo.2019.02.013"},{"key":"e_1_2_11_7_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.rbmo.2016.02.001"},{"key":"e_1_2_11_8_2","doi-asserted-by":"publisher","DOI":"10.1007\/s10815-019-01576-w"},{"key":"e_1_2_11_9_2","first-page":"29","article-title":"Relationship between endometrial thickness and in vitro fertilization-intracytoplasmic sperm injection outcome","volume":"7","author":"Aydin T.","year":"2013","journal-title":"International Journal of Fertility & Sterility"},{"key":"e_1_2_11_10_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.fertnstert.2017.07.006"},{"key":"e_1_2_11_11_2","doi-asserted-by":"publisher","DOI":"10.1196\/annals.1290.042"},{"key":"e_1_2_11_12_2","doi-asserted-by":"publisher","DOI":"10.1093\/biolre\/iox101"},{"key":"e_1_2_11_13_2","doi-asserted-by":"publisher","DOI":"10.1538\/expanim.54.349"},{"key":"e_1_2_11_14_2","first-page":"2723","article-title":"Study of the surface of the uterine epithelium by scanning electron microscope. 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