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CD4+CD8+ double-positive T (DPT) cells have been discovered in recent years to play an important role in autoimmune diseases and viral infections, but the frequency and significance of DPT in primary Sjogren\u2019s syndrome are still unclear. This study detected the frequency of DPT in the peripheral blood of patients with pSS and detected the clinical indicators and cytokines in patients. We then analyzed the correlation between DPT and clinical indicators, cytokines, and disease activity scores. The results showed that the peripheral DPT frequency of pSS patients was significantly higher than that of healthy controls. The peripheral DPT frequency was negatively correlated with ESR, IgA, and IgG, and peripheral DPT frequency was positively correlated with anti-inflammatory cytokine IL-10. Analysis of DPT and pSS disease activity scores found that DPT frequency had a negative correlation with ESSDAI and SSDAI. This study suggests that peripheral DPT may play a protective role in pSS. The frequency of peripheral DPT cells can be used as an indicator for disease activity. Regulating the expression of peripheral DPT cells is expected to become a new strategy for treatment of pSS.<\/jats:p>","DOI":"10.1155\/2021\/6658324","type":"journal-article","created":{"date-parts":[[2021,5,15]],"date-time":"2021-05-15T23:35:06Z","timestamp":1621121706000},"page":"1-9","source":"Crossref","is-referenced-by-count":14,"title":["Increased CD4+CD8+ Double-Positive T Cell in Patients with Primary Sj\u00f6gren\u2019s Syndrome Correlated with Disease Activity"],"prefix":"10.1155","volume":"2021","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9636-6298","authenticated-orcid":true,"given":"Sen","family":"Wang","sequence":"first","affiliation":[{"name":"Department of Clinical Laboratory Medicine, Jinling Hospital, Medical School of Nanjing University, Nanjing 210002, China"},{"name":"Department of Clinical Laboratory Medicine, Nanjing Drum Tower Hospital, Medical School of Nanjing University, Nanjing 210008, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Han","family":"Shen","sequence":"additional","affiliation":[{"name":"Department of Clinical Laboratory Medicine, Nanjing Drum Tower Hospital, Medical School of Nanjing University, Nanjing 210008, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bing","family":"Bai","sequence":"additional","affiliation":[{"name":"Department of Clinical Laboratory Medicine, Nanjing Drum Tower Hospital, Medical School of Nanjing University, Nanjing 210008, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jia","family":"Wu","sequence":"additional","affiliation":[{"name":"Department of Clinical Laboratory Medicine, Jinling Hospital, Medical School of Nanjing University, Nanjing 210002, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5595-0754","authenticated-orcid":true,"given":"Junjun","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Clinical Laboratory Medicine, Jinling Hospital, Medical School of Nanjing University, Nanjing 210002, China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","reference":[{"key":"1","doi-asserted-by":"publisher","DOI":"10.1016\/j.berh.2016.04.003"},{"key":"2","doi-asserted-by":"publisher","DOI":"10.2217\/bmm-2017-0297"},{"key":"3","doi-asserted-by":"publisher","DOI":"10.5114\/reum.2018.75521"},{"issue":"4","key":"4","first-page":"315","article-title":"Pathogenesis of primary Sjogren's syndrome beyond B lymphocytes","volume":"126","author":"S. 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