{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,27]],"date-time":"2026-10-27T06:51:34Z","timestamp":1793083894072,"version":"4.5.0"},"reference-count":104,"publisher":"Wiley","license":[{"start":{"date-parts":[[2021,3,5]],"date-time":"2021-03-05T00:00:00Z","timestamp":1614902400000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100002322","name":"Coordena\u00e7\u00e3o de Aperfei\u00e7oamento de Pessoal de N\u00edvel Superior","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100002322","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003593","name":"Conselho Nacional de Desenvolvimento Cient\u00edfico e Tecnol\u00f3gico","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100003593","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100005667","name":"Funda\u00e7\u00e3o de Amparo \u00e0 Pesquisa e Inova\u00e7\u00e3o do Estado de Santa Catarina","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100005667","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Universidade do Vale do Itaja\u00ed"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Evidence-Based Complementary and Alternative Medicine"],"published-print":{"date-parts":[[2021,3,5]]},"abstract":"<jats:p>The Equisetum genus, Equisetaceae family, is widely distributed worldwide and may be the oldest nonextinct genus on Earth. There are about 30 known species, which are very often used in traditional medicine with diverse applications. This review aimed to compile scientific reports about Equisetum species with relevant pharmacological properties and\/or therapeutic potential for kidney diseases. Our bibliographic survey demonstrates that the most widespread traditional use of Equisetum is as a diuretic, followed by the treatment of genitourinary diseases (kidney diseases, urethritis, kidney stones, and others), inflammation, wound healing, rheumatic diseases, prostatitis, and hypertension. The most popular species from the Equisetum genus with medicinal use is E. arvense L., whose diuretic effect was confirmed in animal models and clinical trials. The species E. bogotense Kunth also demonstrated the beneficial effect of inducing diuresis in both experimental and clinical assays. Several other species have also been studied regarding their therapeutic potential, showing different biological actions. Regarding the chemical composition, it contains many active constituents, such as alkaloids, flavonoids, phenol, phytosterols, saponins, sterols, silicic acid, tannin, triterpenoids, and volatile oils. However, despite the widespread traditional use, many species need to be explored in detail for scientific validation of popular use. Indeed, the species of the Equisetum genus have great potential in the management of kidney disorders.<\/jats:p>","DOI":"10.1155\/2021\/6658434","type":"journal-article","created":{"date-parts":[[2021,3,5]],"date-time":"2021-03-05T17:52:21Z","timestamp":1614966741000},"page":"1-17","source":"Crossref","is-referenced-by-count":50,"title":["Phytochemistry and Pharmacology of the Genus Equisetum (Equisetaceae): A Narrative Review of the Species with Therapeutic Potential for Kidney Diseases"],"prefix":"10.1155","volume":"2021","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3793-6166","authenticated-orcid":true,"given":"Thaise","family":"Boeing","sequence":"first","affiliation":[{"name":"Escola de Ci\u00eancias Farmac\u00eauticas de Ribeir\u00e3o Preto, Universidade de Sa\u0303o Paulo, Ribeira\u0303o Preto, Sa\u0303o Paulo, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0725-7805","authenticated-orcid":true,"given":"Karyne Garcia","family":"Tafarelo Moreno","sequence":"additional","affiliation":[{"name":"Laborat\u00f3rio de Farmacologia Cardiovascular (LaFaC), Faculdade de Ci\u00eancias da Sa\u00fade, Universidade Federal da Grande Dourados, Dourados, MS, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3433-5098","authenticated-orcid":true,"given":"Arquimedes","family":"Gasparotto Junior","sequence":"additional","affiliation":[{"name":"Laborat\u00f3rio de Farmacologia Cardiovascular (LaFaC), Faculdade de Ci\u00eancias da Sa\u00fade, Universidade Federal da Grande Dourados, Dourados, MS, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5329-7301","authenticated-orcid":true,"given":"Luisa","family":"Mota da Silva","sequence":"additional","affiliation":[{"name":"Programa de P\u00f3s-Gradua\u00e7\u00e3o em Ci\u00eancias Farmac\u00eauticas, N\u00facleo de Investiga\u00e7\u00f5es Qu\u00edmico-Farmac\u00eauticas, Universidade do Vale do Itaja\u00ed, Itaja\u00ed, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5251-5642","authenticated-orcid":true,"given":"Priscila","family":"de Souza","sequence":"additional","affiliation":[{"name":"Programa de P\u00f3s-Gradua\u00e7\u00e3o em Ci\u00eancias Farmac\u00eauticas, N\u00facleo de Investiga\u00e7\u00f5es Qu\u00edmico-Farmac\u00eauticas, Universidade do Vale do Itaja\u00ed, Itaja\u00ed, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","reference":[{"key":"1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jep.2014.09.047"},{"key":"2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jep.2007.07.023"},{"key":"3","volume-title":"Encyclopedia of Garden Ferns","author":"S. Olsen","year":"2007","edition":"1st"},{"key":"4","volume-title":"The Herb Society of America, Encyclopedia of Herbs & Their Uses","author":"D. Bown","year":"1995"},{"key":"5","volume-title":"Reader\u2019s Digest- Segredos e Virtudes das Plantas Medicinais","author":"R. Boorhem","year":"1999"},{"key":"6","volume-title":"Medicinal Plants of Brazil","author":"W. B. Mors","year":"2000"},{"key":"7","doi-asserted-by":"publisher","DOI":"10.9790\/3013-0702013142"},{"key":"8","doi-asserted-by":"publisher","DOI":"10.1186\/1746-4269-8-29"},{"issue":"1","key":"9","doi-asserted-by":"crossref","first-page":"129","DOI":"10.2174\/1874312901307010129","article-title":"Effect of aqueous extract of giant horsetail (equisetum giganteum L.) in antigen-induced arthritis","volume":"7","author":"M. Farinon","year":"2014","journal-title":"The Open Rheumatology Journal"},{"key":"10","doi-asserted-by":"publisher","DOI":"10.1155\/2015\/939625"},{"key":"11","doi-asserted-by":"publisher","DOI":"10.1016\/j.jep.2006.07.003"},{"key":"12","doi-asserted-by":"publisher","DOI":"10.1186\/1746-4269-6-29"},{"key":"13","doi-asserted-by":"publisher","DOI":"10.1155\/2014\/760683"},{"key":"14","doi-asserted-by":"publisher","DOI":"10.3109\/13880209.2010.527992"},{"key":"15","doi-asserted-by":"publisher","DOI":"10.3389\/fphar.2020.00215"},{"key":"16","doi-asserted-by":"publisher","DOI":"10.1016\/j.jep.2007.10.031"},{"key":"17","doi-asserted-by":"publisher","DOI":"10.1016\/j.jep.2005.04.019"},{"key":"18","doi-asserted-by":"publisher","DOI":"10.1016\/0378-8741(96)01444-4"},{"key":"19","doi-asserted-by":"publisher","DOI":"10.1016\/j.jep.2008.08.024"},{"key":"20","doi-asserted-by":"publisher","DOI":"10.3390\/nu9010070"},{"key":"21","doi-asserted-by":"publisher","DOI":"10.1016\/j.clindermatol.2018.03.008"},{"key":"22","doi-asserted-by":"publisher","DOI":"10.1186\/1472-6882-14-283"},{"issue":"3","key":"23","doi-asserted-by":"crossref","first-page":"803","DOI":"10.1016\/j.jep.2013.02.006","article-title":"Ethnobotanical study on traditional use of medicinal plants in South-Western Serbia, Zlatibor District","volume":"146","author":"K. \u0160avikin","year":"2013","journal-title":"Journal of Ethnopharmacology"},{"issue":"3","key":"24","doi-asserted-by":"crossref","first-page":"113","DOI":"10.1007\/s11130-007-0050-z","article-title":"Antioxidant, antimicrobial and genotoxicity screening of hydro-alcoholic extracts of five Serbian Equisetum species","volume":"62","author":"V. Milovanovi\u0107","year":"2007","journal-title":"Plant Foods for Human Nutrition"},{"key":"25","doi-asserted-by":"publisher","DOI":"10.1016\/j.jep.2004.08.015"},{"key":"26","doi-asserted-by":"publisher","DOI":"10.1155\/2016\/2853543"},{"key":"27","doi-asserted-by":"publisher","DOI":"10.1016\/j.jep.2012.09.015"},{"key":"28","doi-asserted-by":"publisher","DOI":"10.1016\/j.jep.2005.01.062"},{"key":"29","doi-asserted-by":"publisher","DOI":"10.22490\/24629448.1707"},{"key":"30","doi-asserted-by":"publisher","DOI":"10.1080\/09735070.2017.1335123"},{"key":"31","doi-asserted-by":"publisher","DOI":"10.1016\/j.jep.2012.11.024"},{"key":"32","doi-asserted-by":"crossref","first-page":"647","DOI":"10.1016\/B978-0-12-813822-9.00042-4","article-title":"Chapter 42-traditional herbal products used for the management of diabetes in Croatia: linking traditional use with \u03b1-glucosidase-inhibitory activity","volume-title":"Bioactive Food as Dietary Interventions for Diabetes","author":"M. Zovko Kon\u010di\u0107","year":"2019","edition":"Second"},{"key":"33","doi-asserted-by":"crossref","DOI":"10.1155\/2019\/4513792","article-title":"Ethnobotanical study of medicinal plants used in Central Macedonia, Greece","volume":"2019","author":"E. E. Tsioutsiou","year":"2019","journal-title":"Evidence-Based Complementary and Alternative Medicine"},{"key":"34","doi-asserted-by":"publisher","DOI":"10.1016\/j.jep.2004.07.013"},{"key":"35","doi-asserted-by":"publisher","DOI":"10.1016\/j.jep.2008.11.016"},{"key":"36","doi-asserted-by":"publisher","DOI":"10.1002\/pca.864"},{"key":"37","doi-asserted-by":"publisher","DOI":"10.1080\/13880209.2016.1230636"},{"key":"38","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2184.2012.00848.x"},{"key":"39","doi-asserted-by":"publisher","DOI":"10.5812\/ircmj.25637"},{"key":"40","doi-asserted-by":"publisher","DOI":"10.1016\/j.micpath.2018.01.014"},{"key":"41","doi-asserted-by":"publisher","DOI":"10.3390\/nu9101105"},{"key":"42","doi-asserted-by":"publisher","DOI":"10.1016\/j.jep.2015.03.078"},{"key":"43","doi-asserted-by":"publisher","DOI":"10.1590\/s0102-86502009000600005"},{"key":"44","doi-asserted-by":"publisher","DOI":"10.1293\/tox.23.245"},{"key":"45","doi-asserted-by":"publisher","DOI":"10.1186\/1752-1947-5-129"},{"issue":"3","key":"46","first-page":"190","article-title":"Thiaminase activity in equisetum arvense and its extracts","volume":"26","author":"B. Fabre","year":"1993","journal-title":"Plantes m\u00e9dicinales et phytoth\u00e9rapie"},{"key":"47","first-page":"59","article-title":"Great horsetail (equisetum telmateia Ehrh.): active substances content and biological effects","volume":"11","author":"I. D. Radojevic","year":"2012","journal-title":"EXCLI Journal"},{"key":"48","doi-asserted-by":"publisher","DOI":"10.1002\/ptr.2650060404"},{"key":"49","doi-asserted-by":"publisher","DOI":"10.1016\/j.jep.2006.11.011"},{"key":"50","doi-asserted-by":"publisher","DOI":"10.1016\/j.phytochem.2015.03.003"},{"key":"51","doi-asserted-by":"publisher","DOI":"10.1016\/0031-9422(95)00941-y"},{"key":"52","doi-asserted-by":"publisher","DOI":"10.3390\/molecules13071455"},{"issue":"2","key":"53","first-page":"53","article-title":"Triterpenoids and sterols from equiseturn arvense","volume":"54","author":"Y. Ganeva","year":"2001","journal-title":"Dokladi na Bulgarskata Akademiya na Naukite"},{"issue":"2","key":"54","first-page":"193","article-title":"Three new phenolic glycosides from the fertile sprouts of equisetum arvense","volume":"43","author":"J. Chang","year":"2001","journal-title":"Journal of Integrative Plant Biology"},{"key":"55","doi-asserted-by":"publisher","DOI":"10.1177\/1934578x1300800426"},{"key":"56","doi-asserted-by":"publisher","DOI":"10.1002\/pca.2840"},{"key":"57","doi-asserted-by":"publisher","DOI":"10.1080\/10286020.2011.596829"},{"key":"58","doi-asserted-by":"publisher","DOI":"10.1002\/hlca.200690142"},{"key":"59","doi-asserted-by":"publisher","DOI":"10.1248\/cpb.55.1277"},{"key":"60","doi-asserted-by":"publisher","DOI":"10.1016\/j.talanta.2012.11.072"},{"key":"61","doi-asserted-by":"publisher","DOI":"10.1089\/jmf.2014.0089"},{"key":"62","doi-asserted-by":"publisher","DOI":"10.1080\/14786419.2014.947491"},{"key":"63","doi-asserted-by":"publisher","DOI":"10.1016\/s0305-1978(99)00074-5"},{"issue":"5","key":"64","first-page":"471","article-title":"Chemical Studies on Mexican Plants used in Traditional Medicine XXII: constituents of Equisetum myriochaetum Schlecht. et Cham","volume":"63","author":"M. R. Camacho","year":"1992","journal-title":"Fitoterapia"},{"key":"65","doi-asserted-by":"publisher","DOI":"10.1002\/jssc.201400575"},{"key":"66","doi-asserted-by":"publisher","DOI":"10.1016\/s0378-8741(00)00218-x"},{"key":"67","doi-asserted-by":"publisher","DOI":"10.4314\/tjpr.v14i8.18"},{"issue":"2","key":"68","doi-asserted-by":"crossref","first-page":"138","DOI":"10.1016\/j.jtcme.2017.10.005","article-title":"Clinical study of effectiveness and safety of CELcomplex \u00ae containing cucurbita pepo seed extract and flax and casuarina on stress urinary incontinence in women","volume":"9","author":"A. Ga\u017eov\u00e1","year":"2019","journal-title":"Journal of Traditional and Complementary Medicine"},{"key":"69","doi-asserted-by":"publisher","DOI":"10.1080\/14786419.2018.1539975"},{"issue":"10","key":"70","first-page":"739","article-title":"Antiurolithiasic effect of a plant mixture of herniaria glabra, agropyron repens, equisetum arvense and sambucus nigra (herbensurina\u00ae) in the prevention of experimentally induced nephrolithiasis in rats","volume":"68","author":"A. Crescenti","year":"2015","journal-title":"Arch Esp Urol"},{"key":"71","doi-asserted-by":"publisher","DOI":"10.1016\/j.pharep.2017.05.010"},{"key":"72","doi-asserted-by":"publisher","DOI":"10.1016\/j.jep.2012.03.018"},{"key":"73","doi-asserted-by":"publisher","DOI":"10.1002\/ptr.3431"},{"key":"74","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.2.4725.199"},{"key":"75","doi-asserted-by":"publisher","DOI":"10.1016\/0378-8741(85)90093-5"},{"key":"76","doi-asserted-by":"publisher","DOI":"10.1007\/s00210-018-1502-8"},{"key":"77","doi-asserted-by":"publisher","DOI":"10.1007\/s43450-020-00075-9"},{"key":"78","doi-asserted-by":"publisher","DOI":"10.1021\/acs.jnatprod.0c00274"},{"key":"79","doi-asserted-by":"publisher","DOI":"10.1007\/s11356-019-05420-7"},{"key":"80","doi-asserted-by":"publisher","DOI":"10.3389\/fphar.2019.00027"},{"key":"81","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopha.2018.01.169"},{"key":"82","doi-asserted-by":"publisher","DOI":"10.1039\/c9fo00114j"},{"key":"83","doi-asserted-by":"publisher","DOI":"10.1097\/fjc.0b013e31827cb600"},{"key":"84","doi-asserted-by":"publisher","DOI":"10.1016\/j.phrs.2003.10.002"},{"key":"85","doi-asserted-by":"publisher","DOI":"10.1055\/s-0043-123075"},{"issue":"1","key":"86","first-page":"14","article-title":"Five herbs plus thiamine reduce pain and improve functional mobility in patients with pain: a pilot study","volume":"23","author":"R. Hedaya","year":"2017","journal-title":"Alternative Therapies in Health and Medicine"},{"issue":"2","key":"87","doi-asserted-by":"crossref","first-page":"452","DOI":"10.1089\/jmf.2008.0159","article-title":"Antioxidative and antiproliferative activities of different horsetail (Equisetum arvense L.) extracts","volume":"13","author":"D. D. Cetojevi\u0107-Simin","year":"2010","journal-title":"Journal of Medicinal Food"},{"issue":"2","key":"88","first-page":"3139","article-title":"Investigation of pro-apoptotic activity of Equisetum arvense L. water extract on human leukemia U 937 cells","volume":"12","author":"V. Alexandru","year":"2007","journal-title":"Romanian Biotechnological Letters"},{"issue":"5","key":"89","first-page":"1947","article-title":"Anticancer activity of EA1 extracted from equisetum arvense","volume":"30","author":"H. I. Al Mohammed","year":"2017","journal-title":"Pakistan Journal of Pharmaceutical Sciences"},{"key":"90","doi-asserted-by":"publisher","DOI":"10.1016\/j.sjbs.2020.01.029"},{"issue":"1","key":"91","doi-asserted-by":"crossref","first-page":"85","DOI":"10.1002\/ptr.1815","article-title":"Composition and antimicrobial activity of equisetum arvense L. essential oil","volume":"20","author":"N. Radulovi\u0107","year":"2006","journal-title":"Phytotherapy Research"},{"issue":"4","key":"92","first-page":"2249","article-title":"Equisetum arvense: ethanopharmacological and phytochemical review with reference to osteoporosis","volume":"1","author":"S. Badole","year":"2014","journal-title":"The International Journal of Pharmaceuticals Sciences and Health Care"},{"issue":"2","key":"93","first-page":"77","article-title":"Phytochemical screening of some species of Iranian plants","volume":"2","author":"F. Mojab","year":"2003","journal-title":"Iranian Journal of Pharmaceutical Research"},{"key":"94","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2184.2012.00826.x"},{"key":"95","doi-asserted-by":"publisher","DOI":"10.4103\/0253-7613.182880"},{"issue":"2","key":"96","first-page":"176","article-title":"Effect of equisetum arvense extract on bone mineral density in wistar rats via digital radiography","volume":"10","author":"N. Arbabzadegan","year":"2019","journal-title":"Caspian Journal of Internal Medicine"},{"key":"97","doi-asserted-by":"publisher","DOI":"10.1016\/j.jep.2020.112898"},{"key":"98","doi-asserted-by":"publisher","DOI":"10.1080\/13880209.2017.1321024"},{"key":"99","doi-asserted-by":"publisher","DOI":"10.1016\/s0378-8741(02)00053-3"},{"key":"100","doi-asserted-by":"publisher","DOI":"10.1016\/j.micpath.2016.11.008"},{"key":"101","doi-asserted-by":"publisher","DOI":"10.1016\/j.foodchem.2004.04.016"},{"key":"102","doi-asserted-by":"publisher","DOI":"10.1016\/j.fitote.2006.06.006"},{"key":"103","doi-asserted-by":"publisher","DOI":"10.1016\/j.fitote.2005.04.017"},{"issue":"5","key":"104","first-page":"352","article-title":"Anxiolytic effects of Equisetum arvense Linn. extracts in mice","volume":"49","author":"N. Singh","year":"2011","journal-title":"Indian Journal of Experimental Biology"}],"container-title":["Evidence-Based Complementary and Alternative Medicine"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/downloads.hindawi.com\/journals\/ecam\/2021\/6658434.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/downloads.hindawi.com\/journals\/ecam\/2021\/6658434.xml","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/downloads.hindawi.com\/journals\/ecam\/2021\/6658434.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,3,5]],"date-time":"2021-03-05T17:52:53Z","timestamp":1614966773000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.hindawi.com\/journals\/ecam\/2021\/6658434\/"}},"subtitle":[],"editor":[{"given":"Sebastian","family":"Granica","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"editor"}]}],"short-title":[],"issued":{"date-parts":[[2021,3,5]]},"references-count":104,"alternative-id":["6658434","6658434"],"URL":"https:\/\/doi.org\/10.1155\/2021\/6658434","relation":{},"ISSN":["1741-4288","1741-427X"],"issn-type":[{"value":"1741-4288","type":"electronic"},{"value":"1741-427X","type":"print"}],"subject":[],"published":{"date-parts":[[2021,3,5]]}}}