{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,5]],"date-time":"2025-10-05T12:14:04Z","timestamp":1759666444904,"version":"3.37.3"},"reference-count":44,"publisher":"Wiley","license":[{"start":{"date-parts":[[2021,3,19]],"date-time":"2021-03-19T00:00:00Z","timestamp":1616112000000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100003453","name":"Natural Science Foundation of Guangdong Province","doi-asserted-by":"publisher","award":["2019A1515010360","2020T130132"],"award-info":[{"award-number":["2019A1515010360","2020T130132"]}],"id":[{"id":"10.13039\/501100003453","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002858","name":"China Postdoctoral Science Foundation","doi-asserted-by":"publisher","award":["2019A1515010360","2020T130132"],"award-info":[{"award-number":["2019A1515010360","2020T130132"]}],"id":[{"id":"10.13039\/501100002858","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Oncology"],"published-print":{"date-parts":[[2021,3,19]]},"abstract":"<jats:p>Incidence of hepatoblastoma has been increasing, but the causes of this disease remain unclear. Some studies have suggested that abnormal expressions of ALKBH5 gene are associated with multiple cancers. This study aims to test the hypothesis that hepatoblastoma risk may be modulated by genetic polymorphisms in ALKBH5 gene based on genotyped data from samples of 328 cases and 1476 controls enrolled from eight hospitals in China. We used TaqMan assay to genotype ALKBH5 gene single nucleotide polymorphisms (SNPs) rs1378602G &gt; A and rs8400G &gt; A. We calculated the odds ratios (ORs) and <jats:inline-formula>\n                     <a:math xmlns:a=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M1\">\n                        <a:mi>P<\/a:mi>\n                     <\/a:math>\n                  <\/jats:inline-formula> values using logistic regression models to estimate the association between hepatoblastoma risk and ALKBH5 gene SNPs. We found the rs1378602G &gt; A and rs8400G &gt; A could not impact hepatoblastoma risk in single or combined analysis. Stratified analysis revealed that subjects with the rs8400 AA genotype are prone to getting hepatoblastoma in the clinical stage III\u2009+\u2009IV subgroup (adjusted OR\u2009=\u20091.93, 95% CI\u2009=\u20091.20\u20133.10, <jats:inline-formula>\n                     <c:math xmlns:c=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M2\">\n                        <c:mi>P<\/c:mi>\n                        <c:mo>=<\/c:mo>\n                        <c:mn>0.007<\/c:mn>\n                     <\/c:math>\n                  <\/jats:inline-formula>), when compared to those with GG\/GA genotype. False-positive report probability validated the reliability of the significant results. Preliminary functional annotations revealed that rs8400 A is correlated with increased expression of ALKBH5 gene in the expression quantitative trait locus (eQTL) analysis. In all, our investigation presents evidence of a weak impact of ALKBH5 gene polymorphisms on hepatoblastoma risk, using the largest hepatoblastoma sample size. These findings shed some light on the genetic basis of hepatoblastoma, implicating the role of ALKBH5 gene polymorphisms in the etiology of hepatoblastoma.<\/jats:p>","DOI":"10.1155\/2021\/6658480","type":"journal-article","created":{"date-parts":[[2021,3,20]],"date-time":"2021-03-20T00:50:08Z","timestamp":1616201408000},"page":"1-6","source":"Crossref","is-referenced-by-count":11,"title":["ALKBH5 Gene Polymorphisms and Hepatoblastoma Susceptibility in Chinese Children"],"prefix":"10.1155","volume":"2021","author":[{"given":"Hui","family":"Ren","sequence":"first","affiliation":[{"name":"Department of Pediatric General Surgery, Hebei Children\u2019s Hospital of Hebei Medical University, Shijiazhuang 050031, Hebei, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zhen-Jian","family":"Zhuo","sequence":"additional","affiliation":[{"name":"Department of Pediatric Surgery, Guangzhou Institute of Pediatrics, Guangdong Provincial Key Laboratory of Research in Structural Birth Defect Disease, Guangzhou Women and Children\u2019s Medical Center, Guangzhou Medical University, Guangzhou 510623, Guangdong, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fei","family":"Duan","sequence":"additional","affiliation":[{"name":"Department of Pediatric General Surgery, Hebei Children\u2019s Hospital of Hebei Medical University, Shijiazhuang 050031, Hebei, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yong","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Pediatric Surgery, Hunan Children\u2019s Hospital, Changsha 410004, Hunan, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zhonghua","family":"Yang","sequence":"additional","affiliation":[{"name":"Department of Pediatric Surgery, Shengjing Hospital of China Medical University, Shenyang 110004, Liaoning, 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Children\u2019s Major Disease Research, Yunnan Institute of Pediatrics Research, Yunnan Medical Center for Pediatric Diseases, Kunming Children\u2019s Hospital, Kunming 650228, Yunnan, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jianlei","family":"Geng","sequence":"additional","affiliation":[{"name":"Department of Pediatric General Surgery, Hebei Children\u2019s Hospital of Hebei Medical University, Shijiazhuang 050031, Hebei, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zhiguang","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Pediatric General Surgery, Hebei Children\u2019s Hospital of Hebei Medical University, Shijiazhuang 050031, Hebei, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1954-2892","authenticated-orcid":true,"given":"Jing","family":"He","sequence":"additional","affiliation":[{"name":"Department of Pediatric Surgery, Guangzhou 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