{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,11]],"date-time":"2026-05-11T10:21:28Z","timestamp":1778494888681,"version":"3.51.4"},"reference-count":44,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2021,3,13]],"date-time":"2021-03-13T00:00:00Z","timestamp":1615593600000},"content-version":"vor","delay-in-days":71,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100012226","name":"Fundamental Research Funds for the Central Universities","doi-asserted-by":"publisher","award":["WK9110000044"],"award-info":[{"award-number":["WK9110000044"]}],"id":[{"id":"10.13039\/501100012226","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002858","name":"China Postdoctoral Science Foundation","doi-asserted-by":"publisher","award":["2019M662179"],"award-info":[{"award-number":["2019M662179"]}],"id":[{"id":"10.13039\/501100002858","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81801175"],"award-info":[{"award-number":["81801175"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Oxidative Medicine and Cellular Longevity"],"published-print":{"date-parts":[[2021,1]]},"abstract":"<jats:p>Palmatine (PAL), a natural isoquinoline alkaloid, possesses extensive biological and pharmaceutical activities, including antioxidative stress, anti\u2010inflammatory, antitumor, neuroprotective, and gastroprotective activities. However, it is unknown whether PAL has a protective effect against ischemic stroke and cerebral ischemia\/reperfusion (I\/R) injury. In the present study, a transient middle cerebral artery occlusion (MCAO) mouse model was used to mimic ischemic stroke and cerebral I\/R injury in mice. Our study demonstrated that PAL treatment ameliorated cerebral I\/R injury by decreasing infarct volume, neurological scores, and brain water content. PAL administration attenuated oxidative stress, the inflammatory response, and neuronal apoptosis in mice after cerebral I\/R injury. In addition, PAL treatment also decreases hypoxia and reperfusion\u2010 (H\/R\u2010) induced neuronal injury by reducing oxidative stress, the inflammatory response, and neuronal apoptosis. Moreover, the neuroprotective effects of PAL were associated with the activation of the AMP\u2010activated protein kinase (AMPK)\/nuclear factor E2\u2010related factor 2 (Nrf2) pathway, and Nrf2 knockdown offsets PAL\u2010mediated antioxidative stress and anti\u2010inflammatory effects. Therefore, our results suggest that PAL may be a novel treatment strategy for ischemic stroke and cerebral I\/R injury.<\/jats:p>","DOI":"10.1155\/2021\/6660193","type":"journal-article","created":{"date-parts":[[2021,3,13]],"date-time":"2021-03-13T20:20:09Z","timestamp":1615666809000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":70,"title":["Palmatine Protects against Cerebral Ischemia\/Reperfusion Injury by Activation of the AMPK\/Nrf2 Pathway"],"prefix":"10.1155","volume":"2021","author":[{"given":"Chaoliang","family":"Tang","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Junmou","family":"Hong","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chengyun","family":"Hu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chunxia","family":"Huang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jie","family":"Gao","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jun","family":"Huang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Di","family":"Wang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6873-7821","authenticated-orcid":false,"given":"Qingtian","family":"Geng","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1740-1375","authenticated-orcid":false,"given":"Yongfei","family":"Dong","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2021,3,13]]},"reference":[{"key":"e_1_2_9_1_2","doi-asserted-by":"publisher","DOI":"10.1155\/2020\/5457049"},{"key":"e_1_2_9_2_2","doi-asserted-by":"publisher","DOI":"10.1155\/2019\/3652894"},{"key":"e_1_2_9_3_2","doi-asserted-by":"publisher","DOI":"10.1155\/2020\/2979260"},{"key":"e_1_2_9_4_2","doi-asserted-by":"publisher","DOI":"10.1016\/S1474-4422(19)30030-4"},{"key":"e_1_2_9_5_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ebiom.2018.11.024"},{"key":"e_1_2_9_6_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopha.2020.110870"},{"key":"e_1_2_9_7_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ebiom.2019.03.035"},{"key":"e_1_2_9_8_2","doi-asserted-by":"publisher","DOI":"10.1111\/jcmm.15820"},{"key":"e_1_2_9_9_2","doi-asserted-by":"publisher","DOI":"10.1155\/2020\/5080832"},{"key":"e_1_2_9_10_2","doi-asserted-by":"publisher","DOI":"10.1155\/2020\/6454281"},{"key":"e_1_2_9_11_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.biochi.2019.04.008"},{"key":"e_1_2_9_12_2","doi-asserted-by":"publisher","DOI":"10.14336\/AD.2016.0620"},{"key":"e_1_2_9_13_2","doi-asserted-by":"publisher","DOI":"10.3390\/molecules171011294"},{"key":"e_1_2_9_14_2","doi-asserted-by":"publisher","DOI":"10.1080\/13880209.2020.1784961"},{"key":"e_1_2_9_15_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.fct.2009.10.004"},{"key":"e_1_2_9_16_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.phrs.2018.09.010"},{"key":"e_1_2_9_17_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.fct.2009.05.031"},{"key":"e_1_2_9_18_2","doi-asserted-by":"publisher","DOI":"10.1111\/jcmm.15659"},{"key":"e_1_2_9_19_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.STR.20.1.84"},{"key":"e_1_2_9_20_2","doi-asserted-by":"publisher","DOI":"10.1155\/2020\/8163789"},{"key":"e_1_2_9_21_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.lfs.2016.11.004"},{"key":"e_1_2_9_22_2","doi-asserted-by":"publisher","DOI":"10.1042\/BSR20171562"},{"key":"e_1_2_9_23_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.lfs.2020.118004"},{"key":"e_1_2_9_24_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopha.2020.110357"},{"key":"e_1_2_9_25_2","doi-asserted-by":"publisher","DOI":"10.1089\/ars.2010.3576"},{"key":"e_1_2_9_26_2","doi-asserted-by":"publisher","DOI":"10.1007\/s13311-016-0483-x"},{"key":"e_1_2_9_27_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.brainres.2019.146590"},{"key":"e_1_2_9_28_2","doi-asserted-by":"publisher","DOI":"10.1155\/2020\/4717258"},{"key":"e_1_2_9_29_2","doi-asserted-by":"publisher","DOI":"10.1002\/ptr.6504"},{"key":"e_1_2_9_30_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.pharep.2013.06.001"},{"key":"e_1_2_9_31_2","doi-asserted-by":"publisher","DOI":"10.2174\/1389450117666160401120514"},{"key":"e_1_2_9_32_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopha.2020.109860"},{"key":"e_1_2_9_33_2","doi-asserted-by":"publisher","DOI":"10.1155\/2020\/6801587"},{"key":"e_1_2_9_34_2","doi-asserted-by":"publisher","DOI":"10.1155\/2020\/5291852"},{"key":"e_1_2_9_35_2","doi-asserted-by":"publisher","DOI":"10.1089\/ars.2019.7929"},{"key":"e_1_2_9_36_2","doi-asserted-by":"publisher","DOI":"10.1155\/2020\/2405135"},{"key":"e_1_2_9_37_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejphar.2015.12.003"},{"key":"e_1_2_9_38_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopha.2020.110151"},{"key":"e_1_2_9_39_2","doi-asserted-by":"publisher","DOI":"10.1155\/2020\/6458204"},{"key":"e_1_2_9_40_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopha.2019.108816"},{"key":"e_1_2_9_41_2","doi-asserted-by":"publisher","DOI":"10.1038\/jcbfm.2012.88"},{"key":"e_1_2_9_42_2","doi-asserted-by":"publisher","DOI":"10.1089\/ars.2017.7003"},{"key":"e_1_2_9_43_2","first-page":"199","article-title":"Schizandrin A protects against cerebral ischemia-reperfusion injury by suppressing inflammation and oxidative stress and regulating the AMPK\/Nrf2 pathway regulation","volume":"11","author":"Zhou F.","year":"2019","journal-title":"American Journal of Translational Research"},{"key":"e_1_2_9_44_2","doi-asserted-by":"publisher","DOI":"10.1080\/1061186X.2019.1700262"}],"container-title":["Oxidative Medicine and Cellular Longevity"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/downloads.hindawi.com\/journals\/omcl\/2021\/6660193.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/downloads.hindawi.com\/journals\/omcl\/2021\/6660193.xml","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1155\/2021\/6660193","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,8,7]],"date-time":"2024-08-07T18:51:49Z","timestamp":1723056709000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1155\/2021\/6660193"}},"subtitle":[],"editor":[{"given":"Shi Yuan","family":"Xu","sequence":"additional","affiliation":[],"role":[{"role":"editor","vocabulary":"crossref"}]}],"short-title":[],"issued":{"date-parts":[[2021,1]]},"references-count":44,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2021,1]]}},"alternative-id":["10.1155\/2021\/6660193"],"URL":"https:\/\/doi.org\/10.1155\/2021\/6660193","archive":["Portico"],"relation":{},"ISSN":["1942-0900","1942-0994"],"issn-type":[{"value":"1942-0900","type":"print"},{"value":"1942-0994","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,1]]},"assertion":[{"value":"2020-11-13","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2021-02-21","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2021-03-13","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"6660193"}}