{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,14]],"date-time":"2026-04-14T16:51:07Z","timestamp":1776185467474,"version":"3.50.1"},"reference-count":37,"publisher":"Wiley","license":[{"start":{"date-parts":[[2021,2,2]],"date-time":"2021-02-02T00:00:00Z","timestamp":1612224000000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Evidence-Based Complementary and Alternative Medicine"],"published-print":{"date-parts":[[2021,2,2]]},"abstract":"<jats:p>Objective. To systematically evaluate the efficacy and safety of acupuncture for patients with recurrent implantation failure (RIF) undergoing in vitro fertilization-embryo transfer (IVF-ET) and hopefully provide reliable guidance for clinicians and patients. Methods. Through searching domestic and foreign medical journals, the literature of randomized controlled trials (RCTs) of acupuncture for RIF undergoing IVF-ET was collected. RevMan 5.3 software was used for meta-analysis and Cochrane\u2019s risk of bias assessment tool was used to evaluate the quality of the included studies. Results. Seven documents meeting the criteria were finally included. The results showed that the intervention group contributes more in outcomes including clinical pregnancy rate (RR\u2009=\u20091.90, 95% CI (1.51, 2.40), <jats:inline-formula>\n                     <a:math xmlns:a=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M1\">\n                        <a:mi>P<\/a:mi>\n                        <a:mo>&lt;<\/a:mo>\n                        <a:mn>0.05<\/a:mn>\n                     <\/a:math>\n                  <\/jats:inline-formula>), biochemical pregnancy rate (RR\u2009=\u20091.59, 95% CI (1.27, 1.99), <jats:inline-formula>\n                     <c:math xmlns:c=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M2\">\n                        <c:mi>P<\/c:mi>\n                        <c:mo>&lt;<\/c:mo>\n                        <c:mn>0.05<\/c:mn>\n                     <\/c:math>\n                  <\/jats:inline-formula>), embryo implantation rate (RR\u2009=\u20091.89, 95% CI (1.47, 2.45), <jats:inline-formula>\n                     <e:math xmlns:e=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M3\">\n                        <e:mi>P<\/e:mi>\n                        <e:mo>&lt;<\/e:mo>\n                        <e:mn>0.05<\/e:mn>\n                     <\/e:math>\n                  <\/jats:inline-formula>), and endometrial thickness (MD\u2009=\u20091.11, 95% CI (0.59, 1.63), <jats:inline-formula>\n                     <g:math xmlns:g=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M4\">\n                        <g:mi>P<\/g:mi>\n                        <g:mo>&lt;<\/g:mo>\n                        <g:mn>0.05<\/g:mn>\n                     <\/g:math>\n                  <\/jats:inline-formula>) when compared with the control group, and the difference is statistically significant. In terms of the number of embryo transfers and the type of endometrium, the difference between the acupuncture group and the control group was not statistically significant. Conclusion. Acupuncture therapy on patients with RIF can improve the pregnancy outcome of patients. It is a relatively effective treatment with satisfactory safety and suitable for clinical application. However, as the quality of the included studies is not good enough, the conclusion of this meta-analysis should be treated with caution. More double-blind RCTs equipped with high quality and large samples are expected for the improvement of the level of evidence.<\/jats:p>","DOI":"10.1155\/2021\/6661235","type":"journal-article","created":{"date-parts":[[2021,2,4]],"date-time":"2021-02-04T18:41:41Z","timestamp":1612464101000},"page":"1-11","source":"Crossref","is-referenced-by-count":9,"title":["The Effects of Acupuncture on Pregnancy Outcomes of Recurrent Implantation Failure: A Systematic Review and Meta-Analysis"],"prefix":"10.1155","volume":"2021","author":[{"given":"Menglin","family":"Li","sequence":"first","affiliation":[{"name":"Guangzhou University of Chinese Medicine, Guangzhou, Guangdong, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yunyun","family":"Liu","sequence":"additional","affiliation":[{"name":"Guangzhou University of Chinese Medicine, Guangzhou, Guangdong, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Haoran","family":"Wang","sequence":"additional","affiliation":[{"name":"Guangzhou University of Chinese Medicine, Guangzhou, Guangdong, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shuzhen","family":"Zheng","sequence":"additional","affiliation":[{"name":"The Third Affiliated Hospital of Sun Yat-Sen University, Guangzhou, Guangdong, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yinhe","family":"Deng","sequence":"additional","affiliation":[{"name":"Guangzhou University of Chinese Medicine, Guangzhou, Guangdong, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5936-2415","authenticated-orcid":true,"given":"Yuemei","family":"Li","sequence":"additional","affiliation":[{"name":"The First Affiliated Hospital of Guangzhou University of Chinese Medicine, Guangzhou, Guangdong, China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","reference":[{"key":"1","doi-asserted-by":"publisher","DOI":"10.1016\/j.fertnstert.2012.03.033"},{"key":"2","doi-asserted-by":"publisher","DOI":"10.1016\/j.rbmo.2017.04.004"},{"key":"3","doi-asserted-by":"publisher","DOI":"10.1016\/j.rbmo.2013.12.006"},{"key":"4","doi-asserted-by":"publisher","DOI":"10.1016\/j.rbmo.2013.08.011"},{"key":"5","doi-asserted-by":"publisher","DOI":"10.12688\/f1000research.22403.1"},{"key":"6","doi-asserted-by":"publisher","DOI":"10.1097\/gco.0000000000000620"},{"key":"7","doi-asserted-by":"publisher","DOI":"10.1016\/j.fertnstert.2006.11.042"},{"key":"8","doi-asserted-by":"publisher","DOI":"10.1093\/humupd\/dmw019"},{"key":"9","doi-asserted-by":"publisher","DOI":"10.1136\/acupmed-2017-011629"},{"key":"10","doi-asserted-by":"publisher","DOI":"10.1016\/j.imr.2020.02.003"},{"key":"11","doi-asserted-by":"publisher","DOI":"10.7326\/m14-2385"},{"issue":"5","key":"12","first-page":"32","article-title":"Clinical study of acupuncture on improving endometrial receptivity, emotion of anxiety and depression,and pregnancy outcome in IVF-ET repeated implantation failure patients with syndrome of kidney deficiency and liver stagnation","volume":"33","author":"M. 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