{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,7,30]],"date-time":"2025-07-30T14:24:09Z","timestamp":1753885449051,"version":"3.41.2"},"reference-count":14,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2021,6,24]],"date-time":"2021-06-24T00:00:00Z","timestamp":1624492800000},"content-version":"vor","delay-in-days":174,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100016126","name":"Beijing Hospital Authority","doi-asserted-by":"publisher","award":["QMS20191701"],"award-info":[{"award-number":["QMS20191701"]}],"id":[{"id":"10.13039\/100016126","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["BioMed Research International"],"published-print":{"date-parts":[[2021,1]]},"abstract":"<jats:p><jats:italic>Objective<\/jats:italic>. Little observational data exist regarding the use of cisplatin, etoposide, and bleomycin (BEP) chemotherapy regimen in patients with gestational trophoblastic neoplasia (GTN). <jats:italic>Methods<\/jats:italic>. This is a retrospective study of 95 patients with GTN in our center from June\/2010 to June\/2018. All patients received at least 2 cycles of BEP chemotherapy. The primary outcomes were the rate of complete remission (CR) and overall survival (OS). The secondary outcomes were disease\u2010free survival (DFS), pregnancy rates after BEP exposure, drug resistance rate, and other adverse events. <jats:italic>Results<\/jats:italic>. Of the 95 patients included, 66 (69.5%) patients received BEP as primary treatment and 29 (30.5%) were Salvage chemotherapy. The median age at diagnosis was 37 years (range 29.75\u201046) and 34 years (range 27\u201040) in two groups, respectively. The median WHO prognostic scores were 6 (range 3.5\u20108), and 77.32% of patients were FIGO stage III\u2010IV in the primary treatment group. The median WHO prognostic scores were 5 (range 3\u20109), and 66.55% of patients were FIGO stage III\u2010IV in the salvage treatment group. Median cycles of BEP treatment were 4 (3, 5) and 3 (2, 4) in two groups, respectively. In the primary chemotherapy group, 18.2% received additional hysterectomy, 4.5% received UAE for vaginal bleeding, and 1.52% received whole\u2010brain radiotherapy. In the salvage chemotherapy group, 20.7% received hysterectomy, 6.9% received lobectomy, 3.4% received hysteroscopic lesion resection, and 3.4% received whole\u2010brain radiotherapy. CR rates to initial chemotherapy were 86.4%, including 87.9% in the primary chemotherapy group and 82.8% in the salvage chemotherapy group. No predictive factor of chemotherapy resistance was identified. The rate of 5 year\u2010DFS was 96.52% (95% CI 86.78\u201399.12) in the primary chemotherapy group and 92.44% (95% CI 73.02\u201098.06) in the salvage chemotherapy group. The rate of 5 year\u2010OS was 98.31% (95% CI 88.57\u201399.76) and 95.65% (95% CI 79.93\u201099.38) in the two groups, respectively. During the treatment, neutropenia, thrombocytopenia, anemia, and liver dysfunction occurred in 80.3%, 6.1%, 25.8%, and 50% primary chemotherapy patients and 82.8%, 31%, 10.3%, and 86.2% salvage chemotherapy patients. In patients with fertility requirements, live birth rates were 100% (10\/10) in primary chemotherapy patients and 80% (4\/5) in salvage chemotherapy patients. <jats:italic>Conclusions<\/jats:italic>. BEP regimen was effective in the treatment of GTINs. The treatment was well tolerated, with no safety concerns on patients\u2019 fertility.<\/jats:p>","DOI":"10.1155\/2021\/6661698","type":"journal-article","created":{"date-parts":[[2021,6,24]],"date-time":"2021-06-24T22:35:07Z","timestamp":1624574107000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Real\u2010World Study of Cisplatin, Etoposide, and Bleomycin Chemotherapy Regimen in Gestational Trophoblastic Neoplasia"],"prefix":"10.1155","volume":"2021","author":[{"given":"Ming","family":"Wang","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lianna","family":"Shen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiaohong","family":"Xu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wei","family":"Duan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jinwei","family":"Miao","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Weimin","family":"Kong","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Li","family":"Su","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2242-9348","authenticated-orcid":false,"given":"Yumei","family":"Wu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2021,6,24]]},"reference":[{"key":"e_1_2_11_1_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajog.2010.06.072"},{"key":"e_1_2_11_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0020-7292(03)90120-2"},{"key":"e_1_2_11_3_2","doi-asserted-by":"publisher","DOI":"10.1002\/14651858.CD005196.pub4"},{"key":"e_1_2_11_4_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ygyno.2005.02.004"},{"key":"e_1_2_11_5_2","doi-asserted-by":"publisher","DOI":"10.1002\/14651858.CD008891.pub3"},{"key":"e_1_2_11_6_2","first-page":"726","article-title":"BEP for high-risk gestational trophoblastic tumor: results from a cohort of 45 patients","volume":"36","author":"Song S. Q.","year":"2015","journal-title":"European Journal of Gynaecological Oncology"},{"key":"e_1_2_11_7_2","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2000.18.4.854"},{"key":"e_1_2_11_8_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijgo.2007.03.037"},{"key":"e_1_2_11_9_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1525-1438.2007.00999.x"},{"key":"e_1_2_11_10_2","doi-asserted-by":"publisher","DOI":"10.1093\/annonc\/mdn181"},{"key":"e_1_2_11_11_2","first-page":"88","article-title":"Management of gestational trophoblastic neoplasia with 5-fluorouracil and actinomycin D in northern China","volume":"54","author":"Zhao Y.","year":"2009","journal-title":"Journal of Reproductive Medicine"},{"key":"e_1_2_11_12_2","doi-asserted-by":"publisher","DOI":"10.1016\/s0029-7844(02)02508-5"},{"key":"e_1_2_11_13_2","doi-asserted-by":"publisher","DOI":"10.1093\/annonc\/mdn162"},{"key":"e_1_2_11_14_2","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.1998.16.2.702"}],"container-title":["BioMed Research International"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/downloads.hindawi.com\/journals\/bmri\/2021\/6661698.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/downloads.hindawi.com\/journals\/bmri\/2021\/6661698.xml","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1155\/2021\/6661698","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,12,31]],"date-time":"2024-12-31T16:10:06Z","timestamp":1735661406000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1155\/2021\/6661698"}},"subtitle":[],"editor":[{"given":"A.Seval","family":"Ozgu-Erdinc","sequence":"additional","affiliation":[],"role":[{"role":"editor","vocabulary":"crossref"}]}],"short-title":[],"issued":{"date-parts":[[2021,1]]},"references-count":14,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2021,1]]}},"alternative-id":["10.1155\/2021\/6661698"],"URL":"https:\/\/doi.org\/10.1155\/2021\/6661698","archive":["Portico"],"relation":{},"ISSN":["2314-6133","2314-6141"],"issn-type":[{"type":"print","value":"2314-6133"},{"type":"electronic","value":"2314-6141"}],"subject":[],"published":{"date-parts":[[2021,1]]},"assertion":[{"value":"2020-10-29","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2021-06-15","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2021-06-24","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"6661698"}}