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To ascertain the seasonal pattern and global public interest in osteoporosis by evaluating search term popularity changes of the disease over a decade. <jats:italic>Methods<\/jats:italic>. We applied Google Trends to retrieve search popularity scores for the term \u201costeoporosis\u201d between January 01, 2004, and December 31, 2019. Cosinor analyses were conducted to examine the seasonality of osteoporosis, and analysis on osteoporosis\u2010related topics including hot topics and rising\u2010related topics was also performed. <jats:italic>Results<\/jats:italic>. The cosinor analyses demonstrated a statistically significant seasonal variation in relative search volume of the \u201costeoporosis\u201d in the world (<jats:italic>p<\/jats:italic> = 0.0083), USA (<jats:italic>p<\/jats:italic> &lt; 0.001), UK (<jats:italic>p<\/jats:italic> &lt; 0.001), Canada (<jats:italic>p<\/jats:italic> &lt; 0.001), Ireland (<jats:italic>p<\/jats:italic> &lt; 0.001), Australia (<jats:italic>p<\/jats:italic> &lt; 0.001), and New Zealand (<jats:italic>p<\/jats:italic> &lt; 0.001), with a peak in the late winter months and trough in the summer months. The peaks in late winter and valley in summer presented an approximately 6\u2010month difference between hemispheres. The top 11 rising topics were denosumab, FRAX, hypocalcaemia, zoledronic acid, ibandronic acid, osteomyelitis, osteopenia, osteoarthritis, bone, calcium, and bone density. <jats:italic>Conclusions<\/jats:italic>. Google search query volumes related to osteoporosis follow strong seasonal patterns with late winter peaks and summer troughs. Further studies aimed at elucidating the possible mechanisms behind seasonality in osteoporosis are needed. Moreover, Internet data including the top rising topics may alert physicians to strengthen the propaganda of osteoporosis timely, so as to further promote the development of public health interventions.<\/jats:p>","DOI":"10.1155\/2021\/6663559","type":"journal-article","created":{"date-parts":[[2021,6,5]],"date-time":"2021-06-05T00:36:08Z","timestamp":1622853368000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Seasonal Variation and Global Public Interest in the Internet Searches for Osteoporosis"],"prefix":"10.1155","volume":"2021","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2737-4048","authenticated-orcid":false,"given":"Chao","family":"Wang","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiong","family":"Shu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jianfeng","family":"Tao","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yanzhuo","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yue","family":"Yuan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6918-6216","authenticated-orcid":false,"given":"Chengai","family":"Wu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2021,6,4]]},"reference":[{"key":"e_1_2_10_1_2","doi-asserted-by":"publisher","DOI":"10.1016\/s0140-6736(06)68891-0"},{"key":"e_1_2_10_2_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00198-020-05318-y"},{"key":"e_1_2_10_3_2","doi-asserted-by":"publisher","DOI":"10.1002\/jbmr.2269"},{"key":"e_1_2_10_4_2","doi-asserted-by":"publisher","DOI":"10.1016\/s0140-6736(18)32112-3"},{"key":"e_1_2_10_5_2","doi-asserted-by":"publisher","DOI":"10.5152\/eurjrheum.2016.048"},{"key":"e_1_2_10_6_2","doi-asserted-by":"publisher","DOI":"10.1007\/BF01623184"},{"key":"e_1_2_10_7_2","doi-asserted-by":"publisher","DOI":"10.1093\/bmb\/ldaa005"},{"key":"e_1_2_10_8_2","doi-asserted-by":"publisher","DOI":"10.1097\/BOR.0000000000000365"},{"key":"e_1_2_10_9_2","doi-asserted-by":"publisher","DOI":"10.1016\/s0002-9343(02)01473-0"},{"key":"e_1_2_10_10_2","doi-asserted-by":"publisher","DOI":"10.1001\/jama.287.20.2691"},{"key":"e_1_2_10_11_2","unstructured":"EysenbachG. 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