{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T17:50:04Z","timestamp":1790790604822,"version":"4.1.0"},"reference-count":32,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2021,10,7]],"date-time":"2021-10-07T00:00:00Z","timestamp":1633564800000},"content-version":"vor","delay-in-days":279,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81600970"],"award-info":[{"award-number":["81600970"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["BioMed Research International"],"published-print":{"date-parts":[[2021,1]]},"abstract":"<jats:p><jats:italic>Background<\/jats:italic>. Migraine has a great impact on public health. Current acute therapies do not satisfy all migraineurs. The novel serotonin 5\u2010HT<jats:sub>1F<\/jats:sub> receptor agonist appears more promising for aborting migraine attacks. <jats:italic>Objective<\/jats:italic>. To evaluate the clinical efficacy and safety of lasmiditan in treating acute migraine attacks. <jats:italic>Methods<\/jats:italic>. The literature search was performed in PubMed, Embase, and the Cochrane Central Register of Controlled Trials for randomized controlled trials (RCTs) which assessed the effect and safety of lasmiditan on migraine. The risk of bias was assessed using the Cochrane Collaboration\u2019s risk of bias tool. Results were extracted and pooled as risk ratios (RRs) with a fixed or random\u2010effects model. <jats:italic>Results<\/jats:italic>. Based on the four included RCTs, pooled estimates showed that lasmiditan with the 50\u2009mg, 100\u2009mg, and 200\u2009mg doses was superior to placebo at 2\u2009h after the first dose in terms of pain freedom, absence of migraine\u2010associated symptoms, headache relief, no\/mild disability, and global impression of change (very much\/much better) (RRs ranged from 1.13 to 1.96), except for nausea\u2010free and vomiting\u2010free. Both lasmiditan 100\u2009mg and 200\u2009mg resulted in significantly fewer patients using rescue medication (100\u2009mg: RR = 0.75, 95% CI (0.61, 0.92), <jats:italic>P<\/jats:italic> = 0.007; 200\u2009mg: RR = 0.81, 95% CI (0.66, 0.99), <jats:italic>P<\/jats:italic> = 0.04) at 2\u201024\u2009h postdose, compared with placebo. Safety data showed that the proportion of patients reporting at least one treatment\u2010emergent adverse event (TEAE) and the incidence of most common TEAEs such as dizziness, paresthesia, fatigue, somnolence, and nausea was higher in the lasmiditan groups (50\u2009mg, 100\u2009mg, and 200\u2009mg), compared with placebo. There was no significant difference between lasmiditan and placebo in terms of cardiovascular\u2010related TEAEs (RR = 2.75, 95% CI (0.81, 9.37), <jats:italic>P<\/jats:italic> = 0.11). Compared with lasmiditan 100\u2009mg, lasmiditan 200\u2009mg was more effective in pain freedom at 2\u2009h after the first dose (RR = 0.83, 95% CI (0.74, 0.94), <jats:italic>P<\/jats:italic> = 0.004) but associated with a higher risk of reporting at least one TEAE (RR = 0.88, 95% CI (0.81, 0.96), <jats:italic>P<\/jats:italic> = 0.006). <jats:italic>Conclusions<\/jats:italic>. Lasmiditan with the 50\u2009mg, 100\u2009mg, and 200\u2009mg doses are effective and safe in acute migraine treatment. Lasmiditan 200\u2009mg is more effective than lasmiditan 100\u2009mg in pain freedom, while lasmiditan 100\u2009mg is better tolerated in the short\u2010term follow\u2010up. Further larger sample\u2010size RCTs are required to verify the applicability and tolerability in the long term.<\/jats:p>","DOI":"10.1155\/2021\/6663591","type":"journal-article","created":{"date-parts":[[2021,10,10]],"date-time":"2021-10-10T03:19:20Z","timestamp":1633835960000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["The Effect and Safety of 5\u2010HT<sub>1F<\/sub> Receptor Agonist Lasmiditan on Migraine: A Systematic Review and 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