{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,28]],"date-time":"2026-09-28T22:57:44Z","timestamp":1790636264493,"version":"4.1.0"},"reference-count":35,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2021,6,2]],"date-time":"2021-06-02T00:00:00Z","timestamp":1622592000000},"content-version":"vor","delay-in-days":152,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["BioMed Research International"],"published-print":{"date-parts":[[2021,1]]},"abstract":"<jats:p><jats:italic>Background<\/jats:italic>. The hypermobile type of Ehlers\u2013Danlos syndrome (hEDS) is likely the most common hereditary disorder of connective tissue mainly characterized by joint hypermobility. Patients with hEDS suffer joint pain, in particular low back pain, commonly resistant to drug therapy. The aim of this research was to evaluate a neurocognitive rehabilitation approach based not only on the motion and function recovery but also on the pain management. <jats:italic>Methods<\/jats:italic>. In this nonrandomized clinical trial, eighteen hEDS patients (4 males and 14 females) with mean age 21 years (range 13\u201055) were recruited and evaluated before and after three months of rehabilitation treatment. <jats:italic>Results<\/jats:italic>. The outcome scores showed significant statistical results after treatment in reducing pain symptoms (numerical rating scale, <jats:italic>P<\/jats:italic> = 0.003; McGill (total score), <jats:italic>P<\/jats:italic> = 0.03), fatigue (fatigue severity scale, <jats:italic>P<\/jats:italic> = 0.03), fear of movement (Tampa scale, <jats:italic>P<\/jats:italic> = 0.003), and pain\u2010associated disability (Oswestry disability index, <jats:italic>P<\/jats:italic> = 0.03). <jats:italic>Conclusion<\/jats:italic>. The clinical results observed in our study seem to confirm the role of a specific neurocognitive rehabilitation program in the chronic pain management in the Ehlers\u2013Danlos syndrome; the rehabilitation treatment should be tailored on patient problems and focused not only in the recovery of movement but also on pain perception.<\/jats:p>","DOI":"10.1155\/2021\/6664864","type":"journal-article","created":{"date-parts":[[2021,6,2]],"date-time":"2021-06-02T22:28:37Z","timestamp":1622672917000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":14,"title":["Pain Management through Neurocognitive Therapeutic Exercises in Hypermobile Ehlers\u2013Danlos Syndrome Patients with Chronic Low Back 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