{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,2,21]],"date-time":"2025-02-21T12:18:00Z","timestamp":1740140280142,"version":"3.37.3"},"reference-count":36,"publisher":"Wiley","license":[{"start":{"date-parts":[[2021,4,13]],"date-time":"2021-04-13T00:00:00Z","timestamp":1618272000000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100003621","name":"Ministry of Science, ICT and Future Planning","doi-asserted-by":"publisher","award":["NRF-2020R1F1A1065731"],"award-info":[{"award-number":["NRF-2020R1F1A1065731"]}],"id":[{"id":"10.13039\/501100003621","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Evidence-Based Complementary and Alternative Medicine"],"published-print":{"date-parts":[[2021,4,13]]},"abstract":"<jats:p>Sasang constitutional (SC) medicine classifies people into Soeum (SE), Soyang (SY), Taeeum (TE), and Taeyang (TY) types based on psychological and physical traits. However, biomarkers of these types are still unclear. We aimed to identify biomarkers among the SC types using network pharmacology methods. Target genes associated with the SC types were identified by grouping herb targets that preserve and strengthen the requisite energy (Bomyeongjiju). The herb targets were obtained by constructing an herb-compound-target network. We identified 371, 185, 146, and 89 target genes and their unique biological processes related to SE, SY, TE, and TY types, respectively. While the targets of SE and SY types were the most similar among the target pairs of the SC types, those of TY type overlapped with only a few other SC-type targets. Moreover, SE, SY, TE, and TY were related to \u201cdiseases of the digestive system,\u201d \u201cdiseases of the nervous system,\u201d \u201cendocrine, nutritional, and metabolic diseases,\u201d and \u201ccongenital malformations, deformations, and chromosomal abnormalities,\u201d respectively. We successfully identified the target genes, biological processes, and diseases related to each SC type. We also demonstrated that a drug-centric approach using network pharmacology analysis provides a deeper understanding of the concept of Sasang constitutional medicine at a phenotypic level.<\/jats:p>","DOI":"10.1155\/2021\/6665130","type":"journal-article","created":{"date-parts":[[2021,4,14]],"date-time":"2021-04-14T22:32:36Z","timestamp":1618439556000},"page":"1-10","source":"Crossref","is-referenced-by-count":2,"title":["Investigating the Biomarkers of the Sasang Constitution via Network Pharmacology Approach"],"prefix":"10.1155","volume":"2021","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3902-3755","authenticated-orcid":true,"given":"Won-Yung","family":"Lee","sequence":"first","affiliation":[{"name":"Department of Physiology, College of Korean Medicine, Gachon University, Seongnam, Republic of Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8441-2675","authenticated-orcid":true,"given":"Choong-Yeol","family":"Lee","sequence":"additional","affiliation":[{"name":"Department of Physiology, College of Korean Medicine, Gachon University, Seongnam, Republic of Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8281-9148","authenticated-orcid":true,"given":"Chang-Eop","family":"Kim","sequence":"additional","affiliation":[{"name":"Department of Physiology, College of Korean Medicine, Gachon University, Seongnam, Republic of Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7270-0987","authenticated-orcid":true,"given":"Ji-Hwan","family":"Kim","sequence":"additional","affiliation":[{"name":"Department of Sasang Constitutional Medicine, College of Korean Medicine, Gachon University, Seongnam, Republic of Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","reference":[{"key":"1","doi-asserted-by":"publisher","DOI":"10.1093\/ecam\/nep100"},{"key":"2","doi-asserted-by":"publisher","DOI":"10.1093\/ecam\/nep092"},{"key":"3","doi-asserted-by":"publisher","DOI":"10.1016\/j.imr.2020.100668"},{"key":"4","doi-asserted-by":"publisher","DOI":"10.1089\/acm.2016.0177"},{"key":"5","doi-asserted-by":"publisher","DOI":"10.1186\/1472-6882-13-72"},{"key":"6","doi-asserted-by":"publisher","DOI":"10.1186\/s12906-015-0925-8"},{"key":"7","doi-asserted-by":"publisher","DOI":"10.1155\/2012\/646794"},{"key":"8","doi-asserted-by":"publisher","DOI":"10.1093\/ecam\/nep162"},{"key":"9","doi-asserted-by":"publisher","DOI":"10.1080\/00207450701242883"},{"key":"10","doi-asserted-by":"publisher","DOI":"10.1089\/acm.2011.0434"},{"key":"11","doi-asserted-by":"publisher","DOI":"10.1155\/2018\/9214960"},{"key":"12","doi-asserted-by":"publisher","DOI":"10.1155\/2019\/8783496"},{"key":"13","doi-asserted-by":"publisher","DOI":"10.1016\/j.eujim.2013.05.003"},{"key":"14","doi-asserted-by":"publisher","DOI":"10.1093\/ecam\/neq052"},{"key":"15","doi-asserted-by":"publisher","DOI":"10.3390\/biom9080362"},{"key":"16","doi-asserted-by":"publisher","DOI":"10.1016\/j.jgr.2017.09.001"},{"key":"17","doi-asserted-by":"publisher","DOI":"10.3390\/biom9090407"},{"key":"18","volume-title":"Gugyeokanuihakdaegye 15-Dong-Mu-Yu-Go","author":"D. 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