{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,1]],"date-time":"2025-10-01T16:24:18Z","timestamp":1759335858737,"version":"3.37.3"},"reference-count":44,"publisher":"Wiley","license":[{"start":{"date-parts":[[2021,4,5]],"date-time":"2021-04-05T00:00:00Z","timestamp":1617580800000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100003453","name":"Natural Science Foundation of Guangdong Province","doi-asserted-by":"publisher","award":["2019A15155011733","201804010089","GDREC2018206A"],"award-info":[{"award-number":["2019A15155011733","201804010089","GDREC2018206A"]}],"id":[{"id":"10.13039\/501100003453","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004000","name":"Guangzhou Science and Technology Program key projects","doi-asserted-by":"publisher","award":["2019A15155011733","201804010089","GDREC2018206A"],"award-info":[{"award-number":["2019A15155011733","201804010089","GDREC2018206A"]}],"id":[{"id":"10.13039\/501100004000","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Research Ethics Committee of Guangdong General Hospital","award":["2019A15155011733","201804010089","GDREC2018206A"],"award-info":[{"award-number":["2019A15155011733","201804010089","GDREC2018206A"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Oncology"],"published-print":{"date-parts":[[2021,4,5]]},"abstract":"<jats:p>Hepatectomy is currently one of the most effective treatments for hepatocellular carcinoma (HCC). However, postoperative liver failure (PHLF) is a serious complication and the leading cause of mortality in patients with HCC after hepatectomy. This study attempted to develop a novel nomogram based on noninvasive liver reserve and fibrosis models, platelet-albumin-bilirubin grade (PALBI) and fibrosis-4 index (FIB-4), able to predict PHLF grade B-C. This was a single-centre retrospective study of 574 patients with HCC undergoing hepatectomy between 2014 and 2018. The independent risk factors of PHLF were screened using univariate and multivariate logistic regression analyses. Multivariate logistic regression was performed using the training set, and the nomogram was developed and visualised. The utility of the model was evaluated in a validation set using the receiver operating characteristic (ROC) curve. A total of 574 HCC patients were included (383 in the training set and 191 for the validation set) and included PHLF grade B-C complications of 14.8, 15.4, and 13.6%, respectively. Overall, cirrhosis (<jats:inline-formula>\n                     <a:math xmlns:a=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M1\">\n                        <a:mi>P<\/a:mi>\n                        <a:mo>&lt;<\/a:mo>\n                        <a:mn>0.026<\/a:mn>\n                     <\/a:math>\n                  <\/jats:inline-formula>, OR\u2009=\u20092.296, 95% confidence interval (CI) 1.1.02\u20134.786), major hepatectomy (<jats:inline-formula>\n                     <c:math xmlns:c=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M2\">\n                        <c:mi>P<\/c:mi>\n                        <c:mo>=<\/c:mo>\n                        <c:mn>0.031<\/c:mn>\n                     <\/c:math>\n                  <\/jats:inline-formula>, OR\u2009=\u20092.211, 95% CI 1.077\u20134.542), ascites (<jats:inline-formula>\n                     <e:math xmlns:e=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M3\">\n                        <e:mi>P<\/e:mi>\n                        <e:mo>=<\/e:mo>\n                        <e:mn>0.014<\/e:mn>\n                     <\/e:math>\n                  <\/jats:inline-formula>, OR\u2009=\u20093.588, 95% 1.299\u20139.913), intraoperative blood loss (<jats:inline-formula>\n                     <g:math xmlns:g=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M4\">\n                        <g:mi>P<\/g:mi>\n                        <g:mo>&lt;<\/g:mo>\n                        <g:mn>0.001<\/g:mn>\n                     <\/g:math>\n                  <\/jats:inline-formula>, OR\u2009=\u20094.683, 95% CI 2.281\u20139.616), PALBI score &gt;\u22122.53 (, OR\u2009=\u20093.609, 95% CI 1.486\u20138.764), and FIB-4 score \u22651.45 (<jats:inline-formula>\n                     <i:math xmlns:i=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M5\">\n                        <i:mi>P<\/i:mi>\n                        <i:mo>&lt;<\/i:mo>\n                        <i:mn>0.001<\/i:mn>\n                     <\/i:math>\n                  <\/jats:inline-formula>, OR\u2009=\u20095.267, 95% CI 2.077\u201313.351) were identified as independent risk factors associated with PHLF grade B-C in the training set. The areas under the ROC curves for the nomogram model in predicting PHLF grade B-C were significant for both the training and validation sets (0.832 vs 0.803). The proposed nomogram predicted PHLF grade B-C among patients with HCC with a better prognostic accuracy than other currently available fibrosis and noninvasive liver reserve models.<\/jats:p>","DOI":"10.1155\/2021\/6665267","type":"journal-article","created":{"date-parts":[[2021,4,7]],"date-time":"2021-04-07T22:50:24Z","timestamp":1617835824000},"page":"1-10","source":"Crossref","is-referenced-by-count":11,"title":["Development and Validation of a Nomogram Based on Noninvasive Liver Reserve and Fibrosis (PALBI and FIB-4) Model to Predict Posthepatectomy Liver Failure Grade B-C in Patients with Hepatocellular Carcinoma"],"prefix":"10.1155","volume":"2021","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2574-903X","authenticated-orcid":true,"given":"Wenhui","family":"Zhong","sequence":"first","affiliation":[{"name":"Department of Hepatobiliary Surgery, Guangdong Provincial People\u2019s Hospital, Guangdong Academy of Medical Sciences, Guangzhou 510000, Guangdong, China"},{"name":"Shantou University of Medical College, Shantou 515041, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6795-662X","authenticated-orcid":true,"given":"Feng","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Hepatobiliary Surgery, Guangdong Provincial People\u2019s Hospital, Guangdong Academy of Medical Sciences, Guangzhou 510000, Guangdong, China"},{"name":"Shantou University of Medical College, Shantou 515041, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5172-3212","authenticated-orcid":true,"given":"Kaijun","family":"Huang","sequence":"additional","affiliation":[{"name":"Department of Hepatobiliary Surgery, Guangdong Provincial People\u2019s Hospital, Guangdong Academy of Medical Sciences, Guangzhou 510000, Guangdong, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2880-2147","authenticated-orcid":true,"given":"Yiping","family":"Zou","sequence":"additional","affiliation":[{"name":"Department of Hepatobiliary Surgery, Guangdong Provincial People\u2019s Hospital, Guangdong Academy of Medical Sciences, Guangzhou 510000, Guangdong, China"},{"name":"Shantou University of Medical College, Shantou 515041, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0469-6298","authenticated-orcid":true,"given":"Yubin","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Hepatobiliary Surgery, Guangdong Provincial People\u2019s Hospital, Guangdong Academy of Medical Sciences, Guangzhou 510000, Guangdong, China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","reference":[{"key":"1","doi-asserted-by":"publisher","DOI":"10.1002\/ijc.32975"},{"key":"2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhep.2019.11.017"},{"issue":"1","key":"3","doi-asserted-by":"crossref","first-page":"e2","DOI":"10.1056\/NEJMc1906565","article-title":"Hepatocellular carcinoma","volume":"381","author":"Y. 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