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Encapsulating peritoneal sclerosis (EPS) is a rare but serious complication of peritoneal dialysis (PD). So far, there is no biomarker\u2010based prediction tool available for EPS. Matrix metalloproteinase\u20102 (MMP\u20102) is a protein involved in the breakdown of the extracellular matrix, and the effluent MMP\u20102 can be a potential biomarker of EPS. This study is aimed at developing a nomogram for EPS based on effluent MMP\u20102 levels. <jats:italic>Patients and Methods<\/jats:italic>. We enrolled 18 EPS patients and 90 gender\u2010matched PD patients without EPS in this cross\u2010sectional case\u2010controlled study. The effluent MMP\u20102 levels and possible risk factors for EPS were analyzed using multivariable logistic regression, and a nomogram was developed. The nomogram was validated using 200 bootstrap resamples to reduce overfit bias. <jats:italic>Results<\/jats:italic>. The effluent MMP\u20102 levels in EPS patients were significantly higher than those in normal PD patients (<jats:italic>p<\/jats:italic> &lt; 0.001, Manny\u2010Whitney <jats:italic>U<\/jats:italic> test). Effluent MMP\u20102 levels and PD duration were independently associated with EPS risks (<jats:italic>p<\/jats:italic> &lt; 0.001 and <jats:italic>p<\/jats:italic> = 0.001) in multivariate logistic regression. A nomogram based on MMP\u20102 levels and PD duration was proposed. The AUC of MMP\u20102 was 0.824, and the AUC of the nomogram was 0.907 (<jats:italic>p<\/jats:italic> = 0.05). <jats:italic>Conclusion<\/jats:italic>. A nomogram based on effluent MMP\u20102 levels and PD duration may predict EPS with high accuracy.<\/jats:p>","DOI":"10.1155\/2021\/6666441","type":"journal-article","created":{"date-parts":[[2021,1,20]],"date-time":"2021-01-20T02:20:10Z","timestamp":1611109210000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["A Matrix Metalloproteinase\u20102\u2010Based Nomogram to Assess the Risk of Encapsulating Peritoneal Sclerosis in Peritoneal Dialysis 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