{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,27]],"date-time":"2026-06-27T22:13:59Z","timestamp":1782598439435,"version":"3.54.5"},"reference-count":34,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2021,1,18]],"date-time":"2021-01-18T00:00:00Z","timestamp":1610928000000},"content-version":"vor","delay-in-days":17,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100002865","name":"Chongqing Municipal Science and Technology Bureau","doi-asserted-by":"publisher","award":["cstc2017shmsA130049"],"award-info":[{"award-number":["cstc2017shmsA130049"]}],"id":[{"id":"10.13039\/501100002865","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004374","name":"Chongqing Medical University","doi-asserted-by":"publisher","award":["KY2019L013"],"award-info":[{"award-number":["KY2019L013"]}],"id":[{"id":"10.13039\/501100004374","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["BioMed Research International"],"published-print":{"date-parts":[[2021,1]]},"abstract":"<jats:p><jats:italic>Background<\/jats:italic>. The objective of this systematic review was to evaluate current studies available reporting the antibiotic spacer combined with Ilizarov methods in the treatment of infected nonunion of tibia and to perform meta\u2010analysis of bone results and infection recurrence to assess the efficacy of an antibiotic spacer combined with Ilizarov methods. <jats:italic>Methods<\/jats:italic>. The MEDLINE, Embase, Cochrane Library, CNKI, and CBM (Chinese Biological Medicine) databases were searched for articles published between January 2000 and July 2020. Assessment of study quality was performed using a modified version of the Newcastle\u2010Ottawa scale. Effect size and 95% confidence intervals were calculated for the main outcome. Heterogeneity was assessed. Fixed\u2010effect modeling and Stata version 15.1 were used to analyze the data. Sensitivity analyses were conducted with the evidence of heterogeneity. <jats:italic>Results<\/jats:italic>. 11 studies involving 210 patients with infected nonunion of tibia were finally included in our meta\u2010analysis. Bone results and infection recurrence were analyzed based on the single\u2010arm meta\u2010analysis. The average of external fixation index (EFI) was 46.88 days\/cm in all studies included. The excellent rate in bone results and the rate of infection recurrence was 65% (95% CI: [0.22, 0.97], <jats:italic>I<\/jats:italic><jats:sup>2<\/jats:sup> = 0.0<jats:italic>%<\/jats:italic>, <jats:italic>P<\/jats:italic> = 0.932) and 6.99% (95% CI: [0.052, 0.325], <jats:italic>I<\/jats:italic><jats:sup>2<\/jats:sup> = 0.0<jats:italic>%<\/jats:italic>, <jats:italic>P<\/jats:italic> = 1.000) in patients with infected nonunion of tibia treated with an antibiotic spacer combined with Ilizarov methods. <jats:italic>Conclusions<\/jats:italic>. Our meta\u2010analysis revealed that the patients with infected nonunion of tibia treated with an antibiotic spacer combined with Ilizarov methods had a high rate of excellent bone results and a low rate of infection recurrence. Therefore, combining the antibiotic spacer with Ilizarov methods may be an applicable choice for repairing and reconstructing infected nonunion of tibia.<\/jats:p>","DOI":"10.1155\/2021\/6668617","type":"journal-article","created":{"date-parts":[[2021,1,18]],"date-time":"2021-01-18T22:20:22Z","timestamp":1611008422000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["A Systematic Review and Meta\u2010Analysis of Combined Antibiotic Spacer with Ilizarov Methods in the Treatment of Infected Nonunion of Tibia"],"prefix":"10.1155","volume":"2021","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7031-8941","authenticated-orcid":false,"given":"Zhibo","family":"Deng","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuexi","family":"Mu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xianding","family":"Sun","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yongqing","family":"Xu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2848-015X","authenticated-orcid":false,"given":"Fubing","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9244-4965","authenticated-orcid":false,"given":"Liangjun","family":"Yin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2021,1,18]]},"reference":[{"key":"e_1_2_11_1_2","doi-asserted-by":"publisher","DOI":"10.1302\/0301-620x.98b10.37946"},{"key":"e_1_2_11_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.injury.2007.08.032"},{"key":"e_1_2_11_3_2","doi-asserted-by":"publisher","DOI":"10.1302\/0301-620x.101b11.Bjj-2019-0189.R1"},{"key":"e_1_2_11_4_2","first-page":"118","article-title":"Segmental tibial defects. 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