{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,8,29]],"date-time":"2025-08-29T00:03:35Z","timestamp":1756425815269,"version":"3.44.0"},"reference-count":29,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2021,7,19]],"date-time":"2021-07-19T00:00:00Z","timestamp":1626652800000},"content-version":"vor","delay-in-days":199,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100008903","name":"Ministry of Health and Welfare","doi-asserted-by":"publisher","award":["HI14C1324"],"award-info":[{"award-number":["HI14C1324"]}],"id":[{"id":"10.13039\/100008903","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100008005","name":"Yonsei University College of Medicine","doi-asserted-by":"publisher","award":["6-2019-0184"],"award-info":[{"award-number":["6-2019-0184"]}],"id":[{"id":"10.13039\/501100008005","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Mediators of Inflammation"],"published-print":{"date-parts":[[2021,1]]},"abstract":"<jats:p>Serum interleukin\u2010 (IL\u2010) 27 level has been reported to increase in patients with several autoimmune diseases; however, its significance in patients with antineutrophil cytoplasmic antibody\u2010 (ANCA\u2010) associated vasculitis (AAV) is unknown. In this study, we investigated the associations between serum IL\u201027, laboratory features, and activity of AAV and evaluate the predictive ability of serum IL\u201027 level for disease activity. This study included 77 AAV patients, and we collected clinical and laboratory data at blood sampling. Inflammation\u2010related variables included white blood cell, neutrophil, lymphocyte and platelet counts, serum albumin, erythrocyte sedimentation rate, and C\u2010reactive protein levels. Serum IL\u201027 and IL\u201018 levels were measured from stored sera using Human Magnetic Luminex\u00ae assay. High disease activity of AAV was defined as the highest tertile of Birmingham vasculitis activity score (BVAS) (\u226511). The mean age of the enrolled patients was 59.9 years, and 38 (49.4%) were diagnosed as microscopic polyangiitis. In the multivariable analysis, serum albumin (<jats:italic>\u03b2<\/jats:italic> = \u22120.419) and serum IL\u201027 level (<jats:italic>\u03b2<\/jats:italic> = 0.221) were significantly associated with BVAS. Furthermore, patients with renal manifestation exhibited higher serum IL\u201027 (mean 308.7\u2009pg\/mL vs. 105.8\u2009pg\/mL) and IL\u201018 levels (mean 376.7\u2009pg\/mL vs. 270.4\u2009pg\/mL) than those without. On applying the optimal cut\u2010off of serum IL\u201027 level for predicting high activity, AAV patients with serum IL \u2212 27\u2009level \u2265 300.8\u2009pg\/mL had a significantly higher risk for having high disease activity than those with serum IL \u2212 27\u2009level &lt; 300.8\u2009pg\/mL (relative risk 3.380, 95% confidence interval 1.223, 9.345, <jats:italic>P<\/jats:italic> = 0.016). These results suggest that serum IL\u201027 level is associated with the cross\u2010sectional activity and the presence of renal manifestation and could be used to predict high disease activity in patients with AAV.<\/jats:p>","DOI":"10.1155\/2021\/6668884","type":"journal-article","created":{"date-parts":[[2021,7,19]],"date-time":"2021-07-19T14:20:09Z","timestamp":1626704409000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Predictive Ability of Serum IL\u201027 Level for Assessing Activity of Antineutrophil Cytoplasmic Antibody\u2010Associated Vasculitis"],"prefix":"10.1155","volume":"2021","author":[{"given":"Taejun","family":"Yoon","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sung Soo","family":"Ahn","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jung 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