{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,17]],"date-time":"2026-04-17T00:40:29Z","timestamp":1776386429531,"version":"3.51.2"},"reference-count":10,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2021,5,24]],"date-time":"2021-05-24T00:00:00Z","timestamp":1621814400000},"content-version":"vor","delay-in-days":143,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Case Reports in Endocrinology"],"published-print":{"date-parts":[[2021,1]]},"abstract":"<jats:p>Graves\u2019 disease is the most common cause of hyperthyroidism, which is characterized by thyroid antibodies and the following clinical manifestations: goiter, ophthalmopathy, and pretibial myxedema. On the other hand, Henoch\u2013Sch\u00f6nlein purpura is an IgA\u2010mediated small\u2010vessel vasculitis. Review of the literature showed a relationship between propylthiouracil overdose and the following Henoch\u2013Sch\u00f6nlein purpura (IgA vasculitis) as a side effect. The patient was a 31\u2010year\u2010old woman with a chief complaint of tremor and significant weight loss who contracted pruritic palpable purpura during her disease course. Then, she underwent the treatment of hyperthyroidism by methimazole which intensified her cutaneous lesions. The diagnosis of Henoch\u2013Sch\u00f6nlein purpura (IgA vasculitis) was confirmed after skin biopsy. Finally, she was treated with colchicine, prednisolone, and radioiodine ablation, which caused her lesions to disappear. The temporal priority of pruritic palpable skin lesions to hyperthyroidism treatment with methimazole suggested that Henoch\u2013Sch\u00f6nlein purpura (IgA vasculitis) was related to hyperthyroidism and was intensified by antithyroid agents in this patient.<\/jats:p>","DOI":"10.1155\/2021\/6669653","type":"journal-article","created":{"date-parts":[[2021,5,24]],"date-time":"2021-05-24T14:50:08Z","timestamp":1621867808000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Henoch\u2013Sch\u00f6nlein Purpura (IgA Vasculitis) in Association with Thyrotoxicosis"],"prefix":"10.1155","volume":"2021","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3402-4401","authenticated-orcid":false,"given":"Mojgan","family":"Sanjari","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1300-2940","authenticated-orcid":false,"given":"Mohammadreza","family":"Shakibi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4042-7506","authenticated-orcid":false,"given":"Moeinadin","family":"Safavi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2021,5,24]]},"reference":[{"key":"e_1_2_5_1_2","doi-asserted-by":"publisher","DOI":"10.1016\/s0140-6736(03)14073-1"},{"key":"e_1_2_5_2_2","doi-asserted-by":"publisher","DOI":"10.1002\/art.1780330809"},{"key":"e_1_2_5_3_2","doi-asserted-by":"publisher","DOI":"10.1093\/ndt\/gfl109"},{"key":"e_1_2_5_4_2","doi-asserted-by":"publisher","DOI":"10.1016\/0140-6736(93)91761-a"},{"key":"e_1_2_5_5_2","doi-asserted-by":"publisher","DOI":"10.1093\/oxfordjournals.ndt.a027846"},{"key":"e_1_2_5_6_2","doi-asserted-by":"publisher","DOI":"10.1093\/ndt\/gfh959"},{"key":"e_1_2_5_7_2","doi-asserted-by":"publisher","DOI":"10.1590\/s0004-27302007000100022"},{"key":"e_1_2_5_8_2","doi-asserted-by":"publisher","DOI":"10.4158\/ep09304.cr"},{"key":"e_1_2_5_9_2","doi-asserted-by":"publisher","DOI":"10.1093\/ndt\/gfl287"},{"key":"e_1_2_5_10_2","article-title":"Henoch-Sch\u00f6nlein purpura in adults and autoimmune thyroiditis","volume":"27","author":"Garcia-Porrua C.","year":"2000","journal-title":"The Journal of Rheumatology"}],"container-title":["Case Reports in Endocrinology"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/downloads.hindawi.com\/journals\/crie\/2021\/6669653.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/downloads.hindawi.com\/journals\/crie\/2021\/6669653.xml","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1155\/2021\/6669653","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,11,7]],"date-time":"2025-11-07T00:05:51Z","timestamp":1762473951000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1155\/2021\/6669653"}},"subtitle":[],"editor":[{"given":"Toshihiro","family":"Kita","sequence":"additional","affiliation":[],"role":[{"role":"editor","vocabulary":"crossref"}]}],"short-title":[],"issued":{"date-parts":[[2021,1]]},"references-count":10,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2021,1]]}},"alternative-id":["10.1155\/2021\/6669653"],"URL":"https:\/\/doi.org\/10.1155\/2021\/6669653","archive":["Portico"],"relation":{},"ISSN":["2090-6501","2090-651X"],"issn-type":[{"value":"2090-6501","type":"print"},{"value":"2090-651X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,1]]},"assertion":[{"value":"2020-12-12","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2021-05-10","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2021-05-24","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"6669653"}}