{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,27]],"date-time":"2026-02-27T03:50:10Z","timestamp":1772164210498,"version":"3.50.1"},"reference-count":40,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2021,11,15]],"date-time":"2021-11-15T00:00:00Z","timestamp":1636934400000},"content-version":"vor","delay-in-days":318,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["BioMed Research International"],"published-print":{"date-parts":[[2021,1]]},"abstract":"<jats:p>\n                    <jats:italic>Background<\/jats:italic>\n                    . With the COVID\u201019 epidemic breakout in China, up to 25% of diagnosed cases are considered to be severe. To effectively predict the progression of COVID\u201019 via patients\u2019 clinical features at an early stage, the prevalence of these clinical factors and their relationships with severe illness were assessed.\n                    <jats:italic>Methods<\/jats:italic>\n                    . In this study, electronic databases (PubMed, Embase, Web of Science, and Chinese database) were searched to obtain relevant studies, including information on severe patients. Publication bias analysis, sensitivity analysis, prevalence, sensitivity, specificity, likelihood ratio, diagnosis odds ratio calculation, and visualization graphics were achieved through software Review Manager 5.3, Stata 15, Meta\u2010DiSc 1.4, and R.\n                    <jats:italic>Results<\/jats:italic>\n                    . Data of 3.547 patients from 24 studies were included in this study. The results revealed that patients with chronic respiratory system diseases (pooled positive likelihood 6.07, 95% CI: 3.12\u201011.82), chronic renal disease (4.79, 2.04\u201011.25), cardiovascular disease (3.45, 2.19\u20105.44), and symptoms of the onset of chest tightness (3.8, 1.44\u201010.05), shortness of breath (3.18, 2.24\u20104.51), and diarrhea (2.04, 1.38\u20103.04) exhibited increased probability of progressing to severe illness. C\u2010reactive protein, ratio of neutrophils to lymphocytes, and erythrocyte sedimentation rate increased a lot in severe patients compared to nonsevere. Yet, it was found that clinical features including fever, cough, and headache, as well as some comorbidities, have little warning value.\n                    <jats:italic>Conclusions<\/jats:italic>\n                    . The clinical features and laboratory examination could be used to estimate the process of infection in COVID\u201019 patients. The findings contribute to the more efficient prediction of serious illness for patients with COVID\u201019 to reduce mortality.\n                  <\/jats:p>","DOI":"10.1155\/2021\/6671291","type":"journal-article","created":{"date-parts":[[2021,11,15]],"date-time":"2021-11-15T17:05:08Z","timestamp":1636995908000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Clinical Features and Laboratory Examination to Identify Severe Patients with COVID\u201019: A Systematic Review and Meta\u2010Analysis"],"prefix":"10.1155","volume":"2021","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3198-8061","authenticated-orcid":false,"given":"Yan","family":"Meng","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4379-7403","authenticated-orcid":false,"given":"Jinpeng","family":"Wang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5475-2094","authenticated-orcid":false,"given":"Kaicheng","family":"Wen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9857-2394","authenticated-orcid":false,"given":"Wacili","family":"Da","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3470-0414","authenticated-orcid":false,"given":"Keda","family":"Yang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0619-5406","authenticated-orcid":false,"given":"Siming","family":"Zhou","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8133-1156","authenticated-orcid":false,"given":"Zhengbo","family":"Tao","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7352-7407","authenticated-orcid":false,"given":"Hang","family":"Liu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1702-9833","authenticated-orcid":false,"given":"Lin","family":"Tao","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2021,11,15]]},"reference":[{"key":"e_1_2_8_1_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(20)30211-7"},{"key":"e_1_2_8_2_2","first-page":"67","article-title":"The 2019 novel coronavirus outbreak - a global threat","volume":"68","author":"Khot W. 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