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Buzhong Yiqi prescription (BZYQ) has a significant clinical effect on the treatment of patients with obesity exhibiting PCOS and phlegm-dampness syndrome caused by spleen deficiency (SPSD). Hence, this study aimed to explore gut microbiota and fecal metabolite alterations in such patients treated with BZYQ. Fifty eligible patients with obesity manifesting PCOS and SPSD participated and agreed to undergo 3\u2009months of BZYQ treatment. Results showed that BZYQ significantly alleviated the serum dehydroepiandrosterone sulfate <jats:inline-formula>\n                     <a:math xmlns:a=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M1\">\n                        <a:mfenced open=\"(\" close=\")\" separators=\"|\">\n                           <a:mrow>\n                              <a:mi>p<\/a:mi>\n                              <a:mo>&lt;<\/a:mo>\n                              <a:mn>0.001<\/a:mn>\n                           <\/a:mrow>\n                        <\/a:mfenced>\n                     <\/a:math>\n                  <\/jats:inline-formula> and testosterone levels <jats:inline-formula>\n                     <f:math xmlns:f=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M2\">\n                        <f:mfenced open=\"(\" close=\")\" separators=\"|\">\n                           <f:mrow>\n                              <f:mi>p<\/f:mi>\n                              <f:mo>&lt;<\/f:mo>\n                              <f:mn>0.001<\/f:mn>\n                           <\/f:mrow>\n                        <\/f:mfenced>\n                     <\/f:math>\n                  <\/jats:inline-formula> and markedly changed the gut microbiota structure in these patients. Furthermore, 106 differential fecal metabolites and 14 KEGG enrichment pathways were quantified. The phylum Spirochaetae and the genera [Eubacterium]_rectale_group, Escherichia-Shigella, and Fusicatenibacter were significantly more abundant, but Megamonas was significantly less abundant after treatment than before treatment. Disorders in the gut microbiota and fecal metabolites of these patients were closely related to hyperandrogenemia and insulin resistance. In conclusion, BZYQ could ameliorate the serum androgen level and had an impact on the gut microbiota and metabolites in patients with obesity manifesting PCOS and SPSD.<\/jats:p>","DOI":"10.1155\/2021\/6671367","type":"journal-article","created":{"date-parts":[[2021,3,15]],"date-time":"2021-03-15T22:06:58Z","timestamp":1615846018000},"page":"1-19","source":"Crossref","is-referenced-by-count":20,"title":["Impact of Buzhong Yiqi Prescription on the Gut Microbiota of Patients with Obesity Manifesting Polycystic Ovarian Syndrome"],"prefix":"10.1155","volume":"2021","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9723-2398","authenticated-orcid":true,"given":"Zhexin","family":"Ni","sequence":"first","affiliation":[{"name":"Department of Traditional Chinese Gynecology, Changhai Hospital, Naval Medical University, Shanghai 200433, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7006-4999","authenticated-orcid":true,"given":"Wen","family":"Cheng","sequence":"additional","affiliation":[{"name":"Department of Traditional Chinese Gynecology, Changhai Hospital, Naval Medical University, Shanghai 200433, China"},{"name":"Shanghai University of Traditional Chinese Medicine, Shanghai 201203, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2701-9636","authenticated-orcid":true,"given":"Jie","family":"Ding","sequence":"additional","affiliation":[{"name":"Department of Traditional Chinese Gynecology, Changhai Hospital, Naval Medical University, Shanghai 200433, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4055-1053","authenticated-orcid":true,"given":"Ruipin","family":"Yao","sequence":"additional","affiliation":[{"name":"Department of Traditional Chinese Gynecology, Changhai Hospital, Naval Medical University, Shanghai 200433, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3881-5195","authenticated-orcid":true,"given":"Danying","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Traditional Chinese Gynecology, Changhai Hospital, Naval Medical University, Shanghai 200433, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9053-4537","authenticated-orcid":true,"given":"Dongxia","family":"Zhai","sequence":"additional","affiliation":[{"name":"Department of Traditional Chinese Gynecology, Changhai Hospital, Naval Medical University, Shanghai 200433, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1600-4244","authenticated-orcid":true,"given":"Ling","family":"Zhou","sequence":"additional","affiliation":[{"name":"Department of Traditional Chinese Gynecology, Changhai Hospital, Naval Medical University, Shanghai 200433, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1614-2655","authenticated-orcid":true,"given":"Chaoqin","family":"Yu","sequence":"additional","affiliation":[{"name":"Department of Traditional Chinese Gynecology, Changhai Hospital, Naval Medical University, Shanghai 200433, China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","reference":[{"key":"1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tem.2018.11.001"},{"key":"2","doi-asserted-by":"publisher","DOI":"10.1016\/s2095-4964(17)60331-5"},{"key":"3","doi-asserted-by":"publisher","DOI":"10.1093\/humupd\/dms030"},{"key":"4","doi-asserted-by":"publisher","DOI":"10.1089\/acu.2019.1375"},{"key":"5","doi-asserted-by":"publisher","DOI":"10.1016\/j.phrs.2019.02.024"},{"key":"6","doi-asserted-by":"publisher","DOI":"10.1016\/j.resmic.2018.09.002"},{"key":"7","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2017-02153"},{"key":"8","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0146509"},{"key":"9","doi-asserted-by":"publisher","DOI":"10.1530\/ec-19-0522"},{"key":"10","doi-asserted-by":"publisher","DOI":"10.1038\/s41591-019-0509-0"},{"key":"11","first-page":"1475","article-title":"Intervention effect on modified Buzhong Yiqi decoction in treating rats of liver stagnation and spleen deficiency syndrome","volume":"32","author":"X. 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