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Proteinuria is an early consequence of podocyte injury and a typical sign of kidney disease. Steroid\u2010sensitive patients react well with glucocorticoids, but there is a high chance of multiple relapses. CD80, also known as B7\u20101, is generally expressed on antigen\u2010presenting cells (APCs) in steroid\u2010sensitive MCD patients. Various glomerular disease models associated with proteinuria demonstrated that the detection of CD80 with the increase of urinary CD80 was strongly associated closely with frequent\u2010relapse MCD patients. The role of CD80 in MCD became controversial because one contradicts finding. This review covers the treatment alternatives for MCD with the insight of CD80 as a potential therapeutic target. The promising effectiveness of CD20 (rituximab) antibody and CD80 inhibitor (abatacept) encourages further investigation of CD80 as a therapeutic target in frequent\u2010relapse MCD patients. Therapeutic\u2010based antibody towards CD80 (galiximab) had never been investigated in MCD or any kidney\u2010related disease; hence, the role of CD80 is still undetermined. A new therapeutic approach towards MCD is essential to provide broader effective treatment options besides the general immunosuppressive agents with gruesome adverse effects.<\/jats:p>","DOI":"10.1155\/2021\/6671552","type":"journal-article","created":{"date-parts":[[2021,1,11]],"date-time":"2021-01-11T23:02:02Z","timestamp":1610406122000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":10,"title":["CD80 Insights as Therapeutic Target in the Current and Future Treatment Options of Frequent\u2010Relapse Minimal Change Disease"],"prefix":"10.1155","volume":"2021","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7191-5860","authenticated-orcid":false,"given":"Yoong Mond","family":"Teh","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7589-5150","authenticated-orcid":false,"given":"Soo Kun","family":"Lim","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6920-8542","authenticated-orcid":false,"given":"Norhana","family":"Jusoh","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4192-4245","authenticated-orcid":false,"given":"Kahar","family":"Osman","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6742-3364","authenticated-orcid":false,"given":"Siti Aisyah","family":"Mualif","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2021,1,6]]},"reference":[{"key":"e_1_2_10_1_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.cqn.2014.11.004"},{"key":"e_1_2_10_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(03)14184-0"},{"key":"e_1_2_10_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijpam.2017.12.004"},{"key":"e_1_2_10_4_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(74)91880-7"},{"key":"e_1_2_10_5_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00467-011-1947-1"},{"key":"e_1_2_10_6_2","doi-asserted-by":"publisher","DOI":"10.1038\/ki.1991.232"},{"key":"e_1_2_10_7_2","doi-asserted-by":"publisher","DOI":"10.1007\/s12519-015-0003-9"},{"key":"e_1_2_10_8_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00467-018-3885-7"},{"key":"e_1_2_10_9_2","doi-asserted-by":"publisher","DOI":"10.1053\/j.ajkd.2014.09.022"},{"key":"e_1_2_10_10_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMra1106556"},{"key":"e_1_2_10_11_2","unstructured":"NachmanP.andJenetteJ. 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