{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,14]],"date-time":"2026-05-14T20:29:00Z","timestamp":1778790540045,"version":"3.51.4"},"reference-count":16,"publisher":"Wiley","license":[{"start":{"date-parts":[[2021,3,22]],"date-time":"2021-03-22T00:00:00Z","timestamp":1616371200000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Case Reports in Dermatological Medicine"],"published-print":{"date-parts":[[2021,3,22]]},"abstract":"<jats:p>Background. Halo nevi are often considered benign, and the possibility of malignancy is not always clear to practitioners. We present two case reports suggesting that a halo nevus appearance can be seen in melanoma, even in young adults. A literature search for halo nevi revealing melanoma shows that this is a very rare condition. Case presentation. This report of two young patients indicates the importance of obtaining a detailed history to detect warning signs such as itching, pain, spontaneous bleeding, and previous alterations according to the patient, including a previously totally black colour in an already fully regressed melanoma. Conclusions. The risk of a halo nevus being malignant is higher if there is only one unique halo nevus and no personal or familial history of vitiligo. We postulate that a regressing atypical nevus or a regressing melanoma may be induced by an immunologic reaction as halo nevus type of clinical picture.<\/jats:p>","DOI":"10.1155\/2021\/6672528","type":"journal-article","created":{"date-parts":[[2021,3,23]],"date-time":"2021-03-23T20:05:13Z","timestamp":1616529913000},"page":"1-5","source":"Crossref","is-referenced-by-count":5,"title":["Halo Nevi Are Not Trivial: About 2 Young Patients of Regressed Primary Melanoma That Simulates Halo Nevi"],"prefix":"10.1155","volume":"2021","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6507-5853","authenticated-orcid":true,"given":"S.","family":"De Schrijver","sequence":"first","affiliation":[{"name":"Dermatology Department, CHU UCL Namur, Site Sainte Elisabeth, Place Louise Godin 15, 5000 Namur, Belgium"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1065-3964","authenticated-orcid":true,"given":"I.","family":"Theate","sequence":"additional","affiliation":[{"name":"Institute of Pathology and Genetics (IPG), Avenue George-Lema\u00eetre 25, 6041 Gosselies, Belgium"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7191-2566","authenticated-orcid":true,"given":"O.","family":"Vanhooteghem","sequence":"additional","affiliation":[{"name":"Dermatology Department, CHU UCL Namur, Site Sainte Elisabeth, Place Louise Godin 15, 5000 Namur, Belgium"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","reference":[{"key":"1","doi-asserted-by":"publisher","DOI":"10.1001\/archderm.1965.01600130020003"},{"key":"2","doi-asserted-by":"publisher","DOI":"10.1016\/0190-9622(95)91331-9"},{"key":"3","doi-asserted-by":"publisher","DOI":"10.1016\/s0190-9622(97)70181-6"},{"key":"4","doi-asserted-by":"publisher","DOI":"10.1001\/archderm.1964.01590270053012"},{"key":"5","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaad.2011.11.937"},{"key":"6","doi-asserted-by":"publisher","DOI":"10.1067\/mpd.2001.110276"},{"key":"7","doi-asserted-by":"publisher","DOI":"10.1111\/ijd.12843"},{"key":"8","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0560.1995.tb01417.x"},{"key":"9","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2559.1992.tb00988.x"},{"key":"10","doi-asserted-by":"publisher","DOI":"10.1001\/archderm.142.12.1627"},{"key":"11","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2230.2008.03030.x"},{"key":"12","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2133.2010.10154.x"},{"key":"13","doi-asserted-by":"publisher","DOI":"10.1002\/1097-0142(196807)22:1<69::aid-cncr2820220111>3.0.co;2-d"},{"key":"14","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0560.1975.tb00210.x"},{"key":"15","doi-asserted-by":"publisher","DOI":"10.4103\/0366-6999.218011"},{"key":"16","doi-asserted-by":"publisher","DOI":"10.2340\/00015555-3488"}],"container-title":["Case Reports in Dermatological Medicine"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/downloads.hindawi.com\/journals\/cridm\/2021\/6672528.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/downloads.hindawi.com\/journals\/cridm\/2021\/6672528.xml","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/downloads.hindawi.com\/journals\/cridm\/2021\/6672528.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,3,23]],"date-time":"2021-03-23T20:05:16Z","timestamp":1616529916000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.hindawi.com\/journals\/cridm\/2021\/6672528\/"}},"subtitle":[],"editor":[{"given":"Jacek Cezary","family":"Szepietowski","sequence":"additional","affiliation":[],"role":[{"role":"editor","vocabulary":"crossref"}]}],"short-title":[],"issued":{"date-parts":[[2021,3,22]]},"references-count":16,"alternative-id":["6672528","6672528"],"URL":"https:\/\/doi.org\/10.1155\/2021\/6672528","relation":{},"ISSN":["2090-6471","2090-6463"],"issn-type":[{"value":"2090-6471","type":"electronic"},{"value":"2090-6463","type":"print"}],"subject":[],"published":{"date-parts":[[2021,3,22]]}}}