{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T17:33:54Z","timestamp":1790703234239,"version":"4.1.0"},"reference-count":70,"publisher":"Wiley","license":[{"start":{"date-parts":[[2021,7,2]],"date-time":"2021-07-02T00:00:00Z","timestamp":1625184000000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Tunisian Minister of Higher Education and Scientific Research"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["International Journal of Analytical Chemistry"],"published-print":{"date-parts":[[2021,7,2]]},"abstract":"<jats:p>Rumex crispus L. (R. crispus) is regarded as an aromatic plant. It was used for its excellent biological properties in traditional medicine. The aerial part was extracted successively by maceration with three solvents increasing polarity (cyclohexane (CYH), dichloromethane (DCM), and methanol (MeOH)) to evaluate their chemical compositions and biological activities. The extracts were rich in phenolic compounds (13.0 to 249.8\u2009mg GAE\/g of dry weight (dw)). The MeOH extract has presented remarkable IC50\u2009=\u20096.2\u2009\u03bcg\/mL for anti-DPPH and 31.6\u2009\u03bcg\/mL for anti-AChE. However, the DCM extract has the highest cytotoxic activity against the two cancer cells (HCT-116 and MCF-7) (69.2 and 77.2% inhibition at 50\u2009\u03bcg\/mL, respectively). Interestingly, GC-MS analysis enabled to identify three new compounds in R. crispus extracts, such as L-(\u2212)-arabitol (5), D-(\u2212) fructopyranose (7) detected only in MeOH extract, and 2, 5-dihydroxyacetophenone (3) detected in all extracts. For HPLC chromatograms, cardamonin (8), 5-hydroxy-3\u2032-methoxyflavone (17), and 3\u2032-hydroxy-b-naphthoflavone (18) showed the highest concentrations of 74.0, 55.5, and 50.4\u2009mg\/g of dw, respectively, among others who are identified. Some phenolic compounds were identified and quantified by HPLC in more than one organic extract, such as 4\u2032, 5-dihydroxy-7-methoxyflavone (13), 4\u2032, 5-dihydroxy-7-methoxyflavone (14), 5-hydroxy-3\u2032-methoxyflavone (17), and 3\u2032-hydroxy-b-naphthoflavone (18), were found for the first time in the R. crispus extracts. Our results showed that the biological activities of this plant might be linked to their phenolic compounds and that the polar extracts could be considered as new natural supplements to be used in food and pharmaceuticals.<\/jats:p>","DOI":"10.1155\/2021\/6675436","type":"journal-article","created":{"date-parts":[[2021,7,3]],"date-time":"2021-07-03T18:05:07Z","timestamp":1625335507000},"page":"1-16","source":"Crossref","is-referenced-by-count":23,"title":["Phytochemical Composition, Antioxidant, Antiacetylcholinesterase, and Cytotoxic Activities of Rumex crispus L."],"prefix":"10.1155","volume":"2021","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1609-4887","authenticated-orcid":true,"given":"Mohamed Marouane","family":"Saoudi","sequence":"first","affiliation":[{"name":"Laboratoire de Chimie Analytique et \u00c9lectrochimie, Facult\u00e9 des Sciences de Tunis, Universit\u00e9 de Tunis El Manar, Campus Universitaire, Tunis 2092, Tunisia"},{"name":"Laboratoire de G\u00e9nie Chimique, Universit\u00e9 Paul Sabatier, CNRS, INPT, UPS, Toulouse, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2439-5145","authenticated-orcid":true,"given":"Jalloul","family":"Bouajila","sequence":"additional","affiliation":[{"name":"Laboratoire de G\u00e9nie Chimique, Universit\u00e9 Paul Sabatier, CNRS, INPT, UPS, Toulouse, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7686-7597","authenticated-orcid":true,"given":"Rami","family":"Rahmani","sequence":"additional","affiliation":[{"name":"Laboratoire de G\u00e9nie Chimique, Universit\u00e9 Paul Sabatier, CNRS, INPT, UPS, Toulouse, France"},{"name":"Unit\u00e9 de Recherche \u201cValorisation des Biomol\u00e9cules Actives\u201d, Institut Sup\u00e9rieur de Biologie Appliqu\u00e9e de M\u00e9denine, Route El Jorf\u2014km 22.5, Medenine 4119, Universit\u00e9 de Gab\u00e8s, Gab\u00e8s, Tunisia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1660-8312","authenticated-orcid":true,"given":"Khaled","family":"Alouani","sequence":"additional","affiliation":[{"name":"Laboratoire de Chimie Analytique et \u00c9lectrochimie, Facult\u00e9 des Sciences de Tunis, Universit\u00e9 de Tunis El Manar, Campus Universitaire, Tunis 2092, Tunisia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","reference":[{"key":"1","doi-asserted-by":"publisher","DOI":"10.12816\/0003082"},{"key":"2","doi-asserted-by":"publisher","DOI":"10.3390\/molecules20011118"},{"key":"3","doi-asserted-by":"publisher","DOI":"10.1097\/FPC.0000000000000202"},{"key":"4","doi-asserted-by":"publisher","DOI":"10.4103\/0973-7847.70902"},{"issue":"2","key":"5","first-page":"1074","article-title":"Use of natural antioxidants to scavenge free radicals: a major cause of diseases","volume":"2","author":"S. 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