{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,5,14]],"date-time":"2025-05-14T02:44:25Z","timestamp":1747190665479,"version":"3.40.5"},"reference-count":20,"publisher":"Wiley","license":[{"start":{"date-parts":[[2021,3,8]],"date-time":"2021-03-08T00:00:00Z","timestamp":1615161600000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Case Reports in Critical Care"],"published-print":{"date-parts":[[2021,3,8]]},"abstract":"<jats:p>Spontaneous splenic rupture is a life-threatening condition leading to a rapidly progressing hypovolemic shock due to intra-abdominal blood loss, with a mortality rate of about 10%. Spontaneous splenic rupture can be caused by widely different disorders including acute and chronic infections, neoplastic disorders, and inflammatory noninfectious disorders. In this case report, we present a 67-year-old male patient with hemorrhagic shock caused by an acute bleeding from the splenic artery. The patient was massively transfused with blood products and fluids and underwent laparotomy for hemostatic control and clinical stabilization. Multiorgan involvement by amyloid light-chain amyloidosis (AL-amyloidosis) caused by plasma cell dyscrasia, specifically with infiltration of the spleen artery, was found to be the underlying cause of his life-threatening bleeding. Based on this case, we discuss the features of serious spleen bleeding, massive transfusion therapy in the intensive care setting, and AL-amyloidosis pathophysiology and treatment.<\/jats:p>","DOI":"10.1155\/2021\/6676407","type":"journal-article","created":{"date-parts":[[2021,3,9]],"date-time":"2021-03-09T21:05:06Z","timestamp":1615323906000},"page":"1-6","source":"Crossref","is-referenced-by-count":1,"title":["Spontaneous Splenic Artery Rupture as the First Symptom of Systemic Amyloidosis"],"prefix":"10.1155","volume":"2021","author":[{"given":"\u00d8yvind","family":"Bruserud","sequence":"first","affiliation":[{"name":"Department of Anaesthesia and Intensive Care, Haukeland University Hospital, Bergen, Norway"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tor Henrik Anderson","family":"Tvedt","sequence":"additional","affiliation":[{"name":"Department of Medicine, Haukeland University Hospital, Bergen, Norway"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Aymen Bushra","family":"Ahmed","sequence":"additional","affiliation":[{"name":"Department of Medicine, Haukeland University Hospital, Bergen, Norway"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Olav Karsten","family":"Vintermyr","sequence":"additional","affiliation":[{"name":"Department of Pathology, Haukeland University Hospital, Bergen, Norway"},{"name":"Department of Clinical Science, University of Bergen, Bergen, Norway"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tor","family":"Hervig","sequence":"additional","affiliation":[{"name":"Department of Clinical Science, University of Bergen, Bergen, Norway"},{"name":"Department of Immunology and Transfusion Medicine, Haugesund Hospital, Norway"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anne Berit","family":"Guttormsen","sequence":"additional","affiliation":[{"name":"Department of Anaesthesia and Intensive Care, Haukeland University Hospital, Bergen, Norway"},{"name":"Department of Clinical Medicine, University of Bergen, Bergen, Norway"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5439-8411","authenticated-orcid":true,"given":"H\u00e5kon","family":"Reikvam","sequence":"additional","affiliation":[{"name":"Department of Medicine, Haukeland University Hospital, Bergen, Norway"},{"name":"Department of Clinical Science, University of Bergen, Bergen, Norway"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","reference":[{"key":"1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMra1705649"},{"key":"2","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2012-12-473066"},{"key":"3","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2004.03.029"},{"key":"4","doi-asserted-by":"publisher","DOI":"10.1097\/TA.0000000000001333"},{"key":"5","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2014-05-575340"},{"key":"6","doi-asserted-by":"publisher","DOI":"10.1001\/2013.jamasurg.387"},{"key":"7","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2015.12"},{"key":"8","doi-asserted-by":"publisher","DOI":"10.1097\/CCM.0b013e31829a6ecb"},{"key":"9","doi-asserted-by":"crossref","first-page":"44","DOI":"10.1093\/milmed\/usy120","article-title":"Whole blood transfusion","volume":"183","author":"A. 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