{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,31]],"date-time":"2025-12-31T08:03:18Z","timestamp":1767168198387,"version":"build-2238731810"},"reference-count":28,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2021,3,15]],"date-time":"2021-03-15T00:00:00Z","timestamp":1615766400000},"content-version":"vor","delay-in-days":73,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Youth Project of Shanghai Pudong New Area Municipal Health Bureau","award":["PW2018B-04"],"award-info":[{"award-number":["PW2018B-04"]}]},{"name":"Youth Project of Shanghai Pudong New Area Municipal Health Bureau","award":["PWZbr2017-10"],"award-info":[{"award-number":["PWZbr2017-10"]}]},{"name":"Youth Project of Shanghai Pudong New Area Municipal Health Bureau","award":["PWRd 2017-06"],"award-info":[{"award-number":["PWRd 2017-06"]}]},{"name":"Important Weak Subject Construction Project of Pudong Health and Family Planning Commission of Shanghai","award":["PW2018B-04"],"award-info":[{"award-number":["PW2018B-04"]}]},{"name":"Important Weak Subject Construction Project of Pudong Health and Family Planning Commission of Shanghai","award":["PWZbr2017-10"],"award-info":[{"award-number":["PWZbr2017-10"]}]},{"name":"Important Weak Subject Construction Project of Pudong Health and Family Planning Commission of Shanghai","award":["PWRd 2017-06"],"award-info":[{"award-number":["PWRd 2017-06"]}]},{"name":"Pudong New Area Health and Family Planning Commission Subject Leader Course Project","award":["PW2018B-04"],"award-info":[{"award-number":["PW2018B-04"]}]},{"name":"Pudong New Area Health and Family Planning Commission Subject Leader Course Project","award":["PWZbr2017-10"],"award-info":[{"award-number":["PWZbr2017-10"]}]},{"name":"Pudong New Area Health and Family Planning Commission Subject Leader Course Project","award":["PWRd 2017-06"],"award-info":[{"award-number":["PWRd 2017-06"]}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["BioMed Research International"],"published-print":{"date-parts":[[2021,1]]},"abstract":"<jats:p>\n                    <jats:italic>Objective<\/jats:italic>\n                    . To detect the endothelial function of external iliac artery in rats with different stages of atherosclerosis by high\u2010resolution ultrasound, so as to provide experimental methodological basis for evaluating the function of vascular endothelial cells by ultrasound.\n                    <jats:italic>Methods<\/jats:italic>\n                    . The animals were randomly divided into the control group (\n                    <jats:italic>n<\/jats:italic>\n                    = 6) and the atherosclerosis model group (\n                    <jats:italic>n<\/jats:italic>\n                    = 15). The atherosclerosis group was further divided into 4\u2010week group, 8\u2010week group, and 12\u2010week group, with 5 animals in each group. After separating and grinding rat spleen, the obtained cells were cultured by density gradient centrifugation. After the cells adhered, the morphology of the cells was observed under a microscope and identified by DiI\u2010Ac\u2010LDL and FITC\u2010UEA\u2010I double staining. The activities of LDH and SOD, the contents of MDA and GSH, and the contents of NO in plasma were detected by biochemical methods.\n                    <jats:italic>Results<\/jats:italic>\n                    . The protective effect of rosanilin on brain injury in rats with acute hypobaric hypoxia and its regulation on the expression of pAkt protein; ox\u2010LDL inhibited the proliferation activity of EPCs in a concentration\u2010dependent manner. The expression of KLF2 and S1PR1 in HAEC can be knocked down by small interfering RNA, and knocking down KLF2 can not only downregulate the expression of S1PR1 but also downregulate HAVEN. With the development of atherosclerosis, the endothelium\u2010dependent relaxation function and endothelium\u2010independent relaxation function of the control group and the atherosclerosis model at 4, 8, and 12 weeks were damaged in different degrees and gradually aggravated.\n                    <jats:italic>Conclusion<\/jats:italic>\n                    . Atherosclerosis is a disease with both morphological and functional damage, and vascular endothelial function is damaged in the early stage with corresponding pathological changes. Ultrasound is an effective method to evaluate vascular endothelial function.\n                  <\/jats:p>","DOI":"10.1155\/2021\/6680356","type":"journal-article","created":{"date-parts":[[2021,3,15]],"date-time":"2021-03-15T21:35:29Z","timestamp":1615844129000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["[Retracted] Study on Damage Mechanism and Repair of Vascular Endothelial Cells Based on Ultrasound 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