{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,21]],"date-time":"2025-10-21T15:44:09Z","timestamp":1761061449826,"version":"3.41.2"},"reference-count":37,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2021,7,16]],"date-time":"2021-07-16T00:00:00Z","timestamp":1626393600000},"content-version":"vor","delay-in-days":196,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100005872","name":"Bahir Dar University","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100005872","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["BioMed Research International"],"published-print":{"date-parts":[[2021,1]]},"abstract":"<jats:p><jats:italic>Background<\/jats:italic>. Soil\u2010transmitted helminths (STHs) and <jats:italic>Schistosoma mansoni<\/jats:italic> are the main causes of morbidity among schoolchildren in the tropics. A school\u2010based deworming program was launched to control and eliminate the infection in endemic countries including Ethiopia. Although periodic deworming is conducted in endemic areas, the prevalence of the infection is high in the country. In addition, periodic evaluation of the efficacy of the anthelminthic drug is limited. <jats:italic>Objective<\/jats:italic>. This study is aimed at checking the efficacy of mebendazole and praziquantel with the respective STHs and <jats:italic>Schistosoma mansoni<\/jats:italic> parasites. <jats:italic>Methods<\/jats:italic>. A longitudinal study was conducted from February to March 2018 among 422 schoolchildren. Stool samples were collected at baseline and at 2 and 4 weeks posttreatment and were processed using the Kato\u2010Katz technique. Schoolchildren positive for STHs were treated with mebendazole and those positive for <jats:italic>Schistosoma mansoni<\/jats:italic> with praziquantel. After two weeks, a second round of stool was collected and examined, and then, single\u2010dose redosing was given to each positive child. Lastly, the third stool sample was collected two weeks after the initiation of the redosing and checked for STHs and <jats:italic>S. mansoni<\/jats:italic> parasites. A close follow\u2010up of students who were treated was done. All the data were entered and analyzed using SPSS version 20 for analysis. Descriptive statistics was used to compute the cure rate and egg reduction rate of mebendazole and praziquantel. <jats:italic>Results<\/jats:italic>. Among 422 participants, the prevalence of STHs, hookworm, <jats:italic>Ascaris lumbricoides<\/jats:italic>, and <jats:italic>S. mansoni<\/jats:italic> was 44.7%, 35.1%, 21.1%, and 13.9%, respectively. The cure rate of mebendazole against <jats:italic>A. lumbricoides<\/jats:italic> increased from 60% in the single dose to 100% in redosing after two weeks. The cure rate of mebendazole against hookworm also increased from 32.4% in the single dose to 91.0% in the redosing. The cure rate of praziquantel against <jats:italic>S. mansoni<\/jats:italic>\u2010infected children was 91.5% in the first round and 100% in the redosing phase. There was a 98.6\u2010100% egg reduction rate in the redosing regimen of both drugs. <jats:italic>Conclusion<\/jats:italic>. The cure and egg reduction rates of single\u2010dose mebendazole in the treatment of hookworm and <jats:italic>A. lumbricoides<\/jats:italic> are lower at week two than at redosing, while cure and egg reduction rates of single\u2010dose praziquantel are satisfactory to treat <jats:italic>S. mansoni<\/jats:italic>. Therefore, single\u2010dose praziquantel to <jats:italic>S. mansoni<\/jats:italic> and redosing of single\u2010dose mebendazole to <jats:italic>A. lumbricoides<\/jats:italic> and hookworm infections can be used for treatment purposes.<\/jats:p>","DOI":"10.1155\/2021\/6682418","type":"journal-article","created":{"date-parts":[[2021,7,16]],"date-time":"2021-07-16T17:36:32Z","timestamp":1626456992000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Efficacy of Mebendazole and Praziquantel against Soil\u2010Transmitted Helminths and <i>Schistosoma mansoni<\/i> Infections among Schoolchildren in Northwest Ethiopia"],"prefix":"10.1155","volume":"2021","author":[{"given":"Kefale","family":"Ejigu","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0116-1888","authenticated-orcid":false,"given":"Tadesse","family":"Hailu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Megbaru","family":"Alemu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2021,7,16]]},"reference":[{"key":"e_1_2_13_1_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.actatropica.2010.07.001"},{"key":"e_1_2_13_2_2","first-page":"86","article-title":"Soil transmitted helminth infections and schistosomiasis in school age children in sub-Saharan Africa: efficacy of chemotherapeutic intervention since World Health Assembly resolution","volume":"2010","author":"Uneke C.","year":"2001","journal-title":"Tanzania Journal of Health Research"},{"key":"e_1_2_13_3_2","article-title":"Ethiopia schistosomiasis and soil-transmitted helminthes control programme: progress and prospects","volume":"55","author":"Negussu N.","year":"2017","journal-title":"Ethiopian Medical Journal"},{"key":"e_1_2_13_4_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0155915"},{"key":"e_1_2_13_5_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(06)68653-4"},{"key":"e_1_2_13_6_2","doi-asserted-by":"publisher","DOI":"10.4269\/ajtmh.2003.68.86"},{"key":"e_1_2_13_7_2","doi-asserted-by":"publisher","DOI":"10.1186\/1475-2875-9-39"},{"key":"e_1_2_13_8_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMra012396"},{"key":"e_1_2_13_9_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(06)69440-3"},{"key":"e_1_2_13_10_2","unstructured":"World Health Organization Preventive chemotherapy in human helminthiasis: coordinated use of anthelminthic drugs in control interventions a manual for health professionals and programme managers 2006 September 2018http:\/\/apps.who.int\/iris\/handle\/10665\/43535."},{"key":"e_1_2_13_11_2","doi-asserted-by":"publisher","DOI":"10.9734\/BMRJ\/2016\/19506"},{"key":"e_1_2_13_12_2","doi-asserted-by":"publisher","DOI":"10.1128\/CMR.13.2.207"},{"key":"e_1_2_13_13_2","doi-asserted-by":"publisher","DOI":"10.4269\/ajtmh.1997.57.25"},{"key":"e_1_2_13_14_2","doi-asserted-by":"publisher","DOI":"10.4269\/ajtmh.1999.60.932"},{"key":"e_1_2_13_15_2","unstructured":"World Health Organization Assessing the efficacy of anthelminthic drugs against schistosomiasis and soil-transmitted helminthiases 2013 November 2018https:\/\/www.who.int\/iris\/handle\/10665\/79019."},{"key":"e_1_2_13_16_2","doi-asserted-by":"publisher","DOI":"10.1177\/0049475518786835"},{"key":"e_1_2_13_17_2","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2334-11-189"},{"key":"e_1_2_13_18_2","article-title":"Soil-transmitted helminth infections and associated risk factors among schoolchildren in Durbete town","volume":"2015","author":"Alelign T.","year":"2015","journal-title":"Northwestern Ethiopia. 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