{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,8]],"date-time":"2026-09-08T10:38:51Z","timestamp":1788863931851,"version":"build-2803163510"},"reference-count":54,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2021,4,10]],"date-time":"2021-04-10T00:00:00Z","timestamp":1618012800000},"content-version":"vor","delay-in-days":99,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["BioMed Research International"],"published-print":{"date-parts":[[2021,1]]},"abstract":"<jats:p><jats:italic>Introduction<\/jats:italic>. The stem bark of <jats:italic>Ficus thonningii<\/jats:italic> is used by Ethiopian traditional healers and the community for the treatment of peptic ulcer disease. Thus, the current study was aimed at evaluating the antiulcer effect of hydro\u2010methanol extract and solvent fractions of <jats:italic>F. thonningii<\/jats:italic>. <jats:italic>Methods<\/jats:italic>. The stem bark of <jats:italic>F. thonningii<\/jats:italic> was collected and shed dried. Then, the stem bark was extracted by 80% hydro\u2010methanol solvents and dried. The part of the dried hydro\u2010methanol extract was further fractionated with n\u2010hexane, chloroform, and distilled water. Dose\u2010dependent pylorus ligation, curative indomethacin\u2010induced, and time\u2010dependent ethanol\u2010induced ulcer models were evaluated for the hydro\u2010methanol extract and solvent fractions. Statistical analysis was done by using the Statistical Package for the Social Sciences (SPSS) version 24. The analyses were carried out using one\u2010way analysis of variance (ANOVA), followed by Tukey\u2019s multiple comparison tests. The result was considered significant when <jats:italic>p<\/jats:italic> &lt; 0.05. <jats:italic>Results<\/jats:italic>. The extract of <jats:italic>F. thonningii<\/jats:italic> showed a significant (<jats:italic>p<\/jats:italic> &lt; 0.001) reduction in total acidity at all the tested doses (100, 200, and 400\u2009mg\/kg). All the tested doses of the hydro\u2010methanol extract significantly reduced the gastric volume as compared to the vehicle (NC) (<jats:italic>p<\/jats:italic> &lt; 0.01). The gastric pH was significantly (<jats:italic>p<\/jats:italic> &lt; 0.05) increased by 200 and 400\u2009mg\/kg. Similarly, 200\u2009mg\/kg and 400\u2009mg\/kg significantly (<jats:italic>p<\/jats:italic> &lt; 0.05) lowered gastric ulceration as compared to the NC. The hydro\u2010methanol extract and aqueous fractions of <jats:italic>F. thonningii<\/jats:italic> at 200\u2009mg\/kg showed significant (<jats:italic>p<\/jats:italic> &lt; 0.05) reduction in the ulcer index on a repeated dose of the hydro\u2010methanol and solvent fractions. Ulcer healing effect on indomethacin\u2010induced ulcer was not significant (<jats:italic>p<\/jats:italic> &gt; 0.05) for all tested doses of the hydro\u2010methanol extract. <jats:italic>Conclusion<\/jats:italic>. The study demonstrated that the stem bark of <jats:italic>F. thonningii<\/jats:italic> has a potential antiulcer activity that might be due to antisecretory or cytoprotective effects.<\/jats:p>","DOI":"10.1155\/2021\/6685395","type":"journal-article","created":{"date-parts":[[2021,4,10]],"date-time":"2021-04-10T16:05:31Z","timestamp":1618070731000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":15,"title":["Evaluation of <i>In Vivo<\/i> Antiulcer Activity of Hydro\u2010Methanol Extract and Solvent Fractions of the Stem Bark of <i>Ficus thonningii<\/i> (Moraceae) on Rodent Models"],"prefix":"10.1155","volume":"2021","author":[{"given":"Habtalem","family":"Adane","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8262-0590","authenticated-orcid":false,"given":"Seyfe Asrade","family":"Atnafie","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7030-2782","authenticated-orcid":false,"given":"Zemene Demelash","family":"Kifle","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Digambar","family":"Ambikar","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2021,4,10]]},"reference":[{"key":"e_1_2_11_1_2","first-page":"160","article-title":"Herbal drugs with anti-ulcer activity","volume":"2","author":"Kaur D.","year":"2012","journal-title":"Journal of Applied Pharmaceutical Science"},{"key":"e_1_2_11_2_2","doi-asserted-by":"publisher","DOI":"10.1155\/2013\/796405"},{"key":"e_1_2_11_3_2","doi-asserted-by":"publisher","DOI":"10.1111\/apt.14561"},{"key":"e_1_2_11_4_2","doi-asserted-by":"publisher","DOI":"10.9790\/0853-13190520"},{"key":"e_1_2_11_5_2","doi-asserted-by":"publisher","DOI":"10.1590\/S0004-28032011000300003"},{"key":"e_1_2_11_6_2","first-page":"4","article-title":"Prevalence of Helicobacter pylori and risk factors among dyspepsia and non-dyspepsia adults at Assosa General Hospital, West Ethiopia: a comparative study","volume":"31","author":"Dilnessa T.","year":"2017","journal-title":"Ethiopian Journal of Health Development"},{"key":"e_1_2_11_7_2","doi-asserted-by":"publisher","DOI":"10.4314\/thrb.v16i1.3"},{"key":"e_1_2_11_8_2","first-page":"73","article-title":"Antimalarial activity of Calpurnia aurea hydroalcoholic leaf extract in mice infected with Plasmodium berghei","volume":"2","author":"Birhanu Z.","year":"2015","journal-title":"JPHOL"},{"key":"e_1_2_11_9_2","doi-asserted-by":"publisher","DOI":"10.5897\/ajmr11.1111"},{"key":"e_1_2_11_10_2","first-page":"254","article-title":"Ethnobotanical investigation of traditional medicinal plants commercialized in the markets of Mashhad, Iran","volume":"3","author":"Amiri M. 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