{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T20:44:55Z","timestamp":1791233095029,"version":"4.1.0"},"reference-count":50,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2021,6,1]],"date-time":"2021-06-01T00:00:00Z","timestamp":1622505600000},"content-version":"vor","delay-in-days":151,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100008402","name":"Chengdu University of Traditional Chinese Medicine","doi-asserted-by":"publisher","award":["QNXZ2018006"],"award-info":[{"award-number":["QNXZ2018006"]}],"id":[{"id":"10.13039\/501100008402","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["816738578"],"award-info":[{"award-number":["816738578"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81603300"],"award-info":[{"award-number":["81603300"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["BioMed Research International"],"published-print":{"date-parts":[[2021,1]]},"abstract":"<jats:p><jats:italic>Background. Magnolia officinalis<\/jats:italic> Rehd. and Wils. is widely used in Asian countries because of its multiple pharmacological effects. This study investigated the gastroprotective effect and mechanisms of the ethanol extracts from the bark of Magnolia officinalis (MOE) against ethanol\u2010induced gastric mucosal damage in rats. <jats:italic>Methods.<\/jats:italic> MOE was prepared by reflux extraction with 70% ethanol, and its main compounds were analyzed by UPLC\u2010Q\u2010Exactive Orbitrap\u2010MS. DPPH, ABTS, and FRAP methods were used to evaluate the antioxidant capacity of MOE in <jats:italic>vitro<\/jats:italic>. The gastroprotective effects of MOE were evaluated by the area of gastric injury, H&amp;E (hematoxylin\u2010eosin), and PAS (periodic acid\u2010Schiff). The mechanism was explored by measuring the levels of cytokines and protein in the NF\u2010<jats:italic>\u03ba<\/jats:italic>B signaling pathway. <jats:italic>Results.<\/jats:italic> 30 compounds were identified from MOE, mainly including lignans and alkaloids. MOE presented a high antioxidant activity in several oxidant <jats:italic>in vitro<\/jats:italic> systems. Gastric ulcer index and histological examination showed that MOE reduced ethanol\u2010induced gastric mucosal injury in a dose\u2010dependent manner. MOE pretreatment significantly restored the depleted activity of superoxide dismutase (SOD), glutathione peroxidase (GSH\u2010Px) enzymes, reduced malondialdehyde (MDA), and prostaglandin E2 (PGE2) levels in the gastric tissue in rats. In addition, MOE also inhibited the activation of nuclear factor kappa B (NF\u2010<jats:italic>\u03ba<\/jats:italic>B) pathway and decreased the production of proinflammatory cytokines. <jats:italic>Conclusions.<\/jats:italic> The gastroprotective effect of MOE was attributed to the inhibition of oxidative stress and the NF\u2010<jats:italic>\u03ba<\/jats:italic>B inflammatory pathway. The results provided substantial evidence that MOE could be a promising phytomedicine for gastric ulcer prevention.<\/jats:p>","DOI":"10.1155\/2021\/6688414","type":"journal-article","created":{"date-parts":[[2021,6,1]],"date-time":"2021-06-01T15:10:38Z","timestamp":1622560238000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":10,"title":["Gastroprotective Effect of Ethanol Extracts from Bark of Magnolia officinalis on Ethanol\u2010Induced Gastric Mucosal Damage in Rats"],"prefix":"10.1155","volume":"2021","author":[{"given":"Xiao","family":"Wang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shu","family":"Fu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chen","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xin","family":"Nie","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wan","family":"Liao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ming","family":"Zhao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8720-8722","authenticated-orcid":false,"given":"Fang","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2021,6]]},"reference":[{"key":"e_1_2_12_1_2","doi-asserted-by":"publisher","DOI":"10.1007\/s10787-018-0451-7"},{"key":"e_1_2_12_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijbiomac.2018.01.008"},{"key":"e_1_2_12_3_2","doi-asserted-by":"publisher","DOI":"10.3390\/nu10111680"},{"key":"e_1_2_12_4_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.carbpol.2020.116620"},{"key":"e_1_2_12_5_2","doi-asserted-by":"publisher","DOI":"10.1159\/000357855"},{"key":"e_1_2_12_6_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.intimp.2017.09.011"},{"key":"e_1_2_12_7_2","doi-asserted-by":"publisher","DOI":"10.1002\/ptr.6148"},{"key":"e_1_2_12_8_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jep.2019.112473"},{"key":"e_1_2_12_9_2","doi-asserted-by":"publisher","DOI":"10.1631\/jzus.B1600299"},{"key":"e_1_2_12_10_2","doi-asserted-by":"publisher","DOI":"10.1055\/a-0642-1966"},{"key":"e_1_2_12_11_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.pharmthera.2011.01.010"},{"key":"e_1_2_12_12_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.eujim.2011.09.002"},{"key":"e_1_2_12_13_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.fct.2017.12.058"},{"key":"e_1_2_12_14_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jff.2017.08.028"},{"key":"e_1_2_12_15_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jep.2017.06.045"},{"key":"e_1_2_12_16_2","volume-title":"Pharmacopoeia of the People\u2019s Republic of China","author":"Commission CP","year":"2015"},{"key":"e_1_2_12_17_2","volume-title":"Pharmacological and Pharmacological Experiments of Traditional Chinese Medicine Beijing","author":"Peng C.","year":"2008"},{"key":"e_1_2_12_18_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jep.2020.113104"},{"key":"e_1_2_12_19_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.fct.2019.05.047"},{"key":"e_1_2_12_20_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jep.2017.07.006"},{"key":"e_1_2_12_21_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jep.2018.05.040"},{"key":"e_1_2_12_22_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.taap.2013.05.035"},{"key":"e_1_2_12_23_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpba.2019.03.044"},{"key":"e_1_2_12_24_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijbiomac.2018.12.089"},{"key":"e_1_2_12_25_2","doi-asserted-by":"publisher","DOI":"10.1002\/ptr.2160"},{"key":"e_1_2_12_26_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jep.2011.07.010"},{"key":"e_1_2_12_27_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.phymed.2018.06.036"},{"key":"e_1_2_12_28_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jep.2013.04.027"},{"key":"e_1_2_12_29_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jep.2014.12.057"},{"key":"e_1_2_12_30_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jep.2019.02.041"},{"key":"e_1_2_12_31_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jep.2005.01.020"},{"key":"e_1_2_12_32_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jep.2016.10.049"},{"key":"e_1_2_12_33_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijbiomac.2017.08.175"},{"key":"e_1_2_12_34_2","doi-asserted-by":"publisher","DOI":"10.56808\/2985-1130.2903"},{"key":"e_1_2_12_35_2","doi-asserted-by":"publisher","DOI":"10.3389\/fphar.2019.00183"},{"key":"e_1_2_12_36_2","doi-asserted-by":"publisher","DOI":"10.1152\/physrev.00040.2012"},{"key":"e_1_2_12_37_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.cbi.2018.01.014"},{"key":"e_1_2_12_38_2","doi-asserted-by":"publisher","DOI":"10.1089\/jmf.2018.4231"},{"key":"e_1_2_12_39_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopha.2019.01.043"},{"key":"e_1_2_12_40_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.intimp.2016.06.016"},{"key":"e_1_2_12_41_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.cbi.2017.06.007"},{"key":"e_1_2_12_42_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.intimp.2018.03.031"},{"key":"e_1_2_12_43_2","doi-asserted-by":"publisher","DOI":"10.4314\/tjpr.v13i10.11"},{"key":"e_1_2_12_44_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.carbpol.2018.01.004"},{"key":"e_1_2_12_45_2","doi-asserted-by":"publisher","DOI":"10.3389\/fphar.2018.00140"},{"key":"e_1_2_12_46_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.lfs.2018.01.016"},{"key":"e_1_2_12_47_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopha.2018.01.118"},{"key":"e_1_2_12_48_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0071762"},{"key":"e_1_2_12_49_2","doi-asserted-by":"publisher","DOI":"10.1002\/jsfa.9511"},{"key":"e_1_2_12_50_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopha.2018.12.002"}],"container-title":["BioMed Research International"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/downloads.hindawi.com\/journals\/bmri\/2021\/6688414.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/downloads.hindawi.com\/journals\/bmri\/2021\/6688414.xml","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1155\/2021\/6688414","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,12,31]],"date-time":"2024-12-31T07:05:46Z","timestamp":1735628746000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1155\/2021\/6688414"}},"subtitle":[],"editor":[{"given":"Paul Vernyuy","family":"Tan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"editor"}]}],"short-title":[],"issued":{"date-parts":[[2021,1]]},"references-count":50,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2021,1]]}},"alternative-id":["10.1155\/2021\/6688414"],"URL":"https:\/\/doi.org\/10.1155\/2021\/6688414","archive":["Portico"],"relation":{},"ISSN":["2314-6133","2314-6141"],"issn-type":[{"value":"2314-6133","type":"print"},{"value":"2314-6141","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,1]]},"assertion":[{"value":"2020-12-15","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2021-04-15","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2021-06-01","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"6688414"}}