{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,31]],"date-time":"2025-10-31T07:59:24Z","timestamp":1761897564398,"version":"3.40.5"},"reference-count":29,"publisher":"Wiley","license":[{"start":{"date-parts":[[2021,6,25]],"date-time":"2021-06-25T00:00:00Z","timestamp":1624579200000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Advances in Virology"],"published-print":{"date-parts":[[2021,6,25]]},"abstract":"<jats:p>This study aims to assess the risk of severe forms of COVID-19, based on clinical, laboratory, and imaging markers in patients initially admitted to the ward. This is a retrospective observational study, with data from electronic medical records of inpatients, with laboratory confirmation of COVID-19, between March and September 2020, in a hospital from Juiz de Fora-MG, Brazil. Participants (n\u2009=\u200974) were separated into two groups by clinical evolution: those who remained in the ward and those who progressed to the ICU. Mann\u2013Whitney U test was taken for continuous variables and the chi-square test or Fisher\u2019s exact test for categorical variables. Comparing the proposed groups, lower values of lymphocytes (<jats:inline-formula>\n                     <a:math xmlns:a=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M1\">\n                        <a:mi>p<\/a:mi>\n                     <\/a:math>\n                  <\/jats:inline-formula>\u2009=\u2009&lt;0.001) and increases in serum creatinine (<jats:inline-formula>\n                     <c:math xmlns:c=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M2\">\n                        <c:mi>p<\/c:mi>\n                     <\/c:math>\n                  <\/jats:inline-formula>\u2009=\u20090.009), LDH (<jats:inline-formula>\n                     <e:math xmlns:e=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M3\">\n                        <e:mi>p<\/e:mi>\n                     <\/e:math>\n                  <\/jats:inline-formula>\u2009=\u20090.057), troponin (<jats:inline-formula>\n                     <g:math xmlns:g=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M4\">\n                        <g:mi>p<\/g:mi>\n                     <\/g:math>\n                  <\/jats:inline-formula>\u2009=\u20090.018), IL-6 (<jats:inline-formula>\n                     <i:math xmlns:i=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M5\">\n                        <i:mi>p<\/i:mi>\n                     <\/i:math>\n                  <\/jats:inline-formula>\u2009=\u20090.053), complement C4 (<jats:inline-formula>\n                     <k:math xmlns:k=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M6\">\n                        <k:mi>p<\/k:mi>\n                     <\/k:math>\n                  <\/jats:inline-formula>\u2009=\u20090.040), and CRP (<jats:inline-formula>\n                     <m:math xmlns:m=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M7\">\n                        <m:mi>p<\/m:mi>\n                     <\/m:math>\n                  <\/jats:inline-formula>\u2009=\u20090.053) showed significant differences or statistical tendency for clinical deterioration. The average age of the groups was 47.9\u2009\u00b1\u200916.5 and 66.5\u2009\u00b1\u20097.3 years (<jats:inline-formula>\n                     <o:math xmlns:o=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M8\">\n                        <o:mi>p<\/o:mi>\n                     <\/o:math>\n                  <\/jats:inline-formula>\u2009=\u20090.001). Hypertension (<jats:inline-formula>\n                     <q:math xmlns:q=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M9\">\n                        <q:mi>p<\/q:mi>\n                     <\/q:math>\n                  <\/jats:inline-formula>\u2009=\u20090.064), heart disease (<jats:inline-formula>\n                     <s:math xmlns:s=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M10\">\n                        <s:mi>p<\/s:mi>\n                     <\/s:math>\n                  <\/jats:inline-formula>\u2009=\u20090.048), and COPD (<jats:inline-formula>\n                     <u:math xmlns:u=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M11\">\n                        <u:mi>p<\/u:mi>\n                     <\/u:math>\n                  <\/jats:inline-formula>\u2009=\u20090.039) were more linked to ICU admission, as well as the presence of tachypnea on admission (<jats:inline-formula>\n                     <w:math xmlns:w=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M12\">\n                        <w:mi>p<\/w:mi>\n                     <\/w:math>\n                  <\/jats:inline-formula>\u2009=\u20090.051). Ground-glass involvement &gt;25% of the lung parenchyma or pleural effusion on chest CT showed association with evolution to ICU (<jats:inline-formula>\n                     <y:math xmlns:y=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M13\">\n                        <y:mi>p<\/y:mi>\n                     <\/y:math>\n                  <\/jats:inline-formula>\u2009=\u20090.027), as well as bilateral opacifications (<jats:inline-formula>\n                     <ab:math xmlns:ab=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M14\">\n                        <ab:mi>p<\/ab:mi>\n                     <\/ab:math>\n                  <\/jats:inline-formula>\u2009=\u20090.030) when compared to unilateral ones. Laboratory, clinical, and imaging markers may have significant relation with worse outcomes and the need for intensive treatment, being helpful as predictive factors.<\/jats:p>","DOI":"10.1155\/2021\/6689669","type":"journal-article","created":{"date-parts":[[2021,6,29]],"date-time":"2021-06-29T19:05:07Z","timestamp":1624993507000},"page":"1-7","source":"Crossref","is-referenced-by-count":7,"title":["Evaluation of the Risk of Clinical Deterioration among Inpatients with COVID-19"],"prefix":"10.1155","volume":"2021","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5221-5300","authenticated-orcid":true,"given":"V\u00edctor O.","family":"Costa","sequence":"first","affiliation":[{"name":"Medicine, Faculdade de Ci\u00eancias M\u00e9dicas e da Sa\u00fade de Juiz de Fora\u2013SUPREMA, Juiz de Fora 36033-003, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Eveline M.","family":"Nicolini","sequence":"additional","affiliation":[{"name":"Thoracic Surgery, Hospital Monte Sinai, Juiz de Fora 36033-318, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1463-064X","authenticated-orcid":true,"given":"Bruna M. A.","family":"da Costa","sequence":"additional","affiliation":[{"name":"Nursing, Faculdade de Ci\u00eancias M\u00e9dicas e da Sa\u00fade de Juiz de Fora\u2013Suprema, Juiz de Fora 36033-003, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6728-6275","authenticated-orcid":true,"given":"Fabr\u00edcio M.","family":"Teixeira","sequence":"additional","affiliation":[{"name":"Medicine, Faculdade de Ci\u00eancias M\u00e9dicas e da Sa\u00fade de Juiz de Fora\u2013SUPREMA, Juiz de Fora 36033-003, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0961-5557","authenticated-orcid":true,"given":"J\u00falia P.","family":"Ferreira","sequence":"additional","affiliation":[{"name":"Medicine, Faculdade de Ci\u00eancias M\u00e9dicas e da Sa\u00fade de Juiz de Fora\u2013SUPREMA, Juiz de Fora 36033-003, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marcos A.","family":"Moura","sequence":"additional","affiliation":[{"name":"Infectology, Faculdade de Ci\u00eancias M\u00e9dicas e da Sa\u00fade de Juiz de Fora-Suprema, Juiz de Fora 36033-003, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jorge","family":"Montessi","sequence":"additional","affiliation":[{"name":"Thoracic Surgery, Hospital Monte Sinai, Juiz de Fora 36033-318, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rog\u00e9rio L.","family":"Campos","sequence":"additional","affiliation":[{"name":"Psychiatrist and Emergency, Hospital Monte Sinai, Juiz de Fora 36033-318, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Andrea N.","family":"Guaraldo","sequence":"additional","affiliation":[{"name":"Intensive Therapy, Hospital Monte Sinai, Juiz de Fora 36033-318, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Patr\u00edcia M.","family":"Costa","sequence":"additional","affiliation":[{"name":"Intensive Therapy and Dermatology Hospital Monte Sinai, Juiz de Fora 36033-318, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","reference":[{"key":"1","doi-asserted-by":"publisher","DOI":"10.1590\/0102-311x00115320"},{"volume-title":"Coronav\u00edrus Brasil","year":"2020","author":"Ministry of Health","key":"2"},{"volume-title":"WHO Coronavirus Disease (COVID-19) Dashboard","year":"2020","author":"World Health Organization","key":"3"},{"volume-title":"Protocolo Institucional Atendimento ao Paciente com Suspeita ou Confirma\u00e7\u00e3o de COVID-19","year":"2020","author":"Syria Charitable Association","key":"4"},{"key":"5","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijid.2020.03.017"},{"key":"6","doi-asserted-by":"publisher","DOI":"10.1016\/j.jinf.2020.05.064"},{"key":"7","doi-asserted-by":"publisher","DOI":"10.1016\/j.jinf.2020.04.021"},{"volume-title":"Secretaria de Vigil\u00e2ncia em sa\u00fade. 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Francone","year":"2020","journal-title":"European Journal of Radiology"},{"key":"28","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejrad.2020.109009"},{"key":"29","doi-asserted-by":"publisher","DOI":"10.1186\/s12916-020-01726-3"}],"container-title":["Advances in Virology"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/downloads.hindawi.com\/journals\/av\/2021\/6689669.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/downloads.hindawi.com\/journals\/av\/2021\/6689669.xml","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/downloads.hindawi.com\/journals\/av\/2021\/6689669.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,6,29]],"date-time":"2021-06-29T19:05:17Z","timestamp":1624993517000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.hindawi.com\/journals\/av\/2021\/6689669\/"}},"subtitle":[],"editor":[{"given":"Jay C.","family":"Brown","sequence":"additional","affiliation":[],"role":[{"role":"editor","vocabulary":"crossref"}]}],"short-title":[],"issued":{"date-parts":[[2021,6,25]]},"references-count":29,"alternative-id":["6689669","6689669"],"URL":"https:\/\/doi.org\/10.1155\/2021\/6689669","relation":{},"ISSN":["1687-8647","1687-8639"],"issn-type":[{"type":"electronic","value":"1687-8647"},{"type":"print","value":"1687-8639"}],"subject":[],"published":{"date-parts":[[2021,6,25]]}}}