{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T01:48:46Z","timestamp":1787017726675,"version":"build-2736575974"},"reference-count":22,"publisher":"Wiley","license":[{"start":{"date-parts":[[2021,6,7]],"date-time":"2021-06-07T00:00:00Z","timestamp":1623024000000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Advances in Pharmacological and Pharmaceutical Sciences"],"published-print":{"date-parts":[[2021,6,7]]},"abstract":"<jats:p>\n                    Background. Epilepsy is one of the most common serious neurological disorders, responsible for substantial morbidity and mortality due to limited efficacy and negative properties of antiepileptic drugs. Medicinal plants are believed to be an important source of new chemical substances with potential therapeutic effects. Pentas schimperiana (A. Rich.) Vatke is a medicinal plant used in Ethiopian traditional medicine for the treatment of epilepsy. However, it lacks scientific investigation on its anticonvulsant activity. Therefore, this study was conducted to evaluate the anticonvulsant activity of 80% methanol root bark extract and solvent fractions of Pentas schimperiana (A. Rich.) Vatke in mice. Methods. Anticonvulsant activity was evaluated by using the pentylenetetrazole and maximal electroshock-induced seizure test. The 80% methanolic root bark extract was subjected to successive fractionation with solvents differing polarity, i.e., chloroform, butanol, and water. The test groups received 100, 200, and 400\u2009mg\/kg bodyweight of extract and its solvent fractions. Result. The ME400 and BF400 at the higher dose exhibited a significant (\n                    <jats:inline-formula>\n                      <a:math xmlns:a=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M1\">\n                        <a:mi>p<\/a:mi>\n                        <a:mo>&lt;<\/a:mo>\n                        <a:mn>0.001<\/a:mn>\n                      <\/a:math>\n                    <\/jats:inline-formula>\n                    ) anticonvulsant effect in both the pentylenetetrazole and maximal electroshock-induced seizure test compared with control. However, chloroform fraction only showed a significant (\n                    <jats:inline-formula>\n                      <c:math xmlns:c=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M2\">\n                        <c:mi>p<\/c:mi>\n                        <c:mo>&lt;<\/c:mo>\n                        <c:mn>0.001<\/c:mn>\n                      <\/c:math>\n                    <\/jats:inline-formula>\n                    ) anticonvulsant effect in the PTZ-induced seizure test, while aqueous fraction had least anticonvulsant activity in both seizure-induced tests. Phytochemical screening of Pentas schimperiana (A. Rich.) Vatke root bark extract revealed the presence of alkaloids, saponins, flavonoids, phenols, steroids, terpenoids, and tannins. Conclusion. This study indicated that the plant has anticonvulsant activity and is considered as a potential source to develop a new antiepileptic drug.\n                  <\/jats:p>","DOI":"10.1155\/2021\/6689879","type":"journal-article","created":{"date-parts":[[2021,6,9]],"date-time":"2021-06-09T01:35:15Z","timestamp":1623202515000},"page":"1-7","source":"Crossref","is-referenced-by-count":13,"title":["Evaluation of Anticonvulsant Activity of 80% Methanolic Root Bark Extract and Solvent Fractions of Pentas schimperiana (A. Rich.) Vatke (Rubiaceae) in Swiss Albino Mice"],"prefix":"10.1155","volume":"2021","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8296-3104","authenticated-orcid":true,"given":"Nebeyi","family":"Fisseha","sequence":"first","affiliation":[{"name":"Department of Pharmacy, Mizan Tepi University, Mizan Teferi, Ethiopia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3478-6235","authenticated-orcid":true,"given":"Workineh","family":"Shibeshi","sequence":"additional","affiliation":[{"name":"Department of Pharmacology, School of Pharmacy, Addis Ababa University, Addis Ababa, Ethiopia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4007-6443","authenticated-orcid":true,"given":"Daniel","family":"Bisrat","sequence":"additional","affiliation":[{"name":"Department of Pharmacognosy, School of Pharmacy, Addis Ababa University, Addis Ababa, Ethiopia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","reference":[{"key":"1","doi-asserted-by":"publisher","DOI":"10.1016\/s0140-6736(12)61381-6"},{"key":"2","doi-asserted-by":"publisher","DOI":"10.2147\/ndt.s84852"},{"key":"3","doi-asserted-by":"publisher","DOI":"10.1016\/s0140-6736(14)60456-6"},{"key":"4","volume-title":"Epilepsy: A Manual for Medical and Clinical Officers in Africa","author":"P. 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Acute Oral Toxicity","author":"OECD","year":"2008"},{"issue":"9","key":"13","doi-asserted-by":"crossref","first-page":"1329","DOI":"10.3109\/13880209.2014.981280","article-title":"Anticonvulsant activity of aqueous fraction of Carissa edulis root bark","volume":"53","author":"J. Ya\u2019u","year":"2015","journal-title":"Pharmaceutical Biology"},{"issue":"3","key":"14","first-page":"319","article-title":"Comparative assays of antiepileptic drugs in mice and rats","volume":"106","author":"E. A. Swinyard","year":"1952","journal-title":"The Journal of Pharmacology and Experimental Therapeutics"},{"key":"15","first-page":"5","volume-title":"Phytochemical Methods. A Guide to Modern Techniques of Plant Analysis","author":"J. B. Herborne","year":"1973"},{"key":"16","doi-asserted-by":"publisher","DOI":"10.1128\/aac.43.7.1729"},{"issue":"3","key":"17","first-page":"223","article-title":"Antiepileptic drugs: pharmacological mechanisms and clinical efficacy with consideration of promising developmental stage compounds","volume":"42","author":"M. A. Rogawski","year":"1990","journal-title":"Pharmacological Reviews"},{"key":"18","doi-asserted-by":"crossref","DOI":"10.1201\/9780429186851","volume-title":"Neuropharmacology Methods in Epilepsy Research","author":"S. L. Peterson","year":"2019"},{"key":"19","article-title":"The maximal electroshock seizure model in the preclinical assessment of potential new antiepileptic drugs","volume":"31","author":"M. M. Castel-Branco","year":"2009","journal-title":"Methods and Findings in Experimental and Clinical Pharmacology"},{"key":"20","doi-asserted-by":"publisher","DOI":"10.1016\/j.seizure.2011.01.003"},{"key":"21","doi-asserted-by":"publisher","DOI":"10.1016\/j.jep.2015.06.039"},{"key":"22","doi-asserted-by":"crossref","first-page":"49","DOI":"10.22159\/ijpps.2016.v8i9.11716","article-title":"Evaluation of the anticonvulsant activity of Mimosa pudica root linn in Swiss albino mice","volume":"8","author":"C. Prathima","year":"2016","journal-title":"International Journal of Pharmacy and Pharmaceutical Science"}],"container-title":["Advances in Pharmacological and Pharmaceutical Sciences"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/downloads.hindawi.com\/journals\/aps\/2021\/6689879.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/downloads.hindawi.com\/journals\/aps\/2021\/6689879.xml","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/downloads.hindawi.com\/journals\/aps\/2021\/6689879.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,6,9]],"date-time":"2021-06-09T01:35:32Z","timestamp":1623202532000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.hindawi.com\/journals\/aps\/2021\/6689879\/"}},"subtitle":[],"editor":[{"given":"Ghulam","family":"Hussain","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"editor"}]}],"short-title":[],"issued":{"date-parts":[[2021,6,7]]},"references-count":22,"alternative-id":["6689879","6689879"],"URL":"https:\/\/doi.org\/10.1155\/2021\/6689879","relation":{},"ISSN":["2633-4690","2633-4682"],"issn-type":[{"value":"2633-4690","type":"electronic"},{"value":"2633-4682","type":"print"}],"subject":[],"published":{"date-parts":[[2021,6,7]]}}}