{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,26]],"date-time":"2025-10-26T15:06:46Z","timestamp":1761491206518,"version":"3.37.3"},"reference-count":45,"publisher":"Wiley","license":[{"start":{"date-parts":[[2021,3,23]],"date-time":"2021-03-23T00:00:00Z","timestamp":1616457600000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81771891"],"award-info":[{"award-number":["81771891"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Oncology"],"published-print":{"date-parts":[[2021,3,23]]},"abstract":"<jats:p>In clinical practice, tegafur, gimeracil, and oteracil potassium (S-1) therapy is commonly administered to treat nasopharyngeal carcinoma (NPC). However, its efficacy and safety remain controversial in both randomized controlled trials (RCTs) and non-RCTs. We aimed to evaluate the efficacy and safety of S-1 treatment for NPC. We searched PubMed, Ovid, EMBASE, the Cochrane Library, China National Knowledge Infrastructure, Wanfang Database, and VIP databases for RCTs of chemotherapy with or without S-1 for NPC, from 2001 to 2020. A meta-analysis was performed using RevMan5.3 and Stata15. Randomized controlled trials published in journals were included irrespective of blinding and language used. Patients were diagnosed with NPC through a clinicopathological examination; patients of all cancer stages and ages were included. Overall, 25 trials and 1858 patients were included. There were significant differences in the complete remission (OR\u2009=\u20092.42, 95% CI (1.88\u20133.10), <jats:inline-formula>\n                     <a:math xmlns:a=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M1\">\n                        <a:mi>P<\/a:mi>\n                        <a:mo>&lt;<\/a:mo>\n                        <a:mn>0.05<\/a:mn>\n                     <\/a:math>\n                  <\/jats:inline-formula>) and overall response rate (OR\u2009=\u20092.68, 95% CI (2.08\u20133.45), <jats:inline-formula>\n                     <c:math xmlns:c=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M2\">\n                        <c:mi>P<\/c:mi>\n                        <c:mo>&lt;<\/c:mo>\n                        <c:mn>0.05<\/c:mn>\n                     <\/c:math>\n                  <\/jats:inline-formula>) between the S-1 and non-S-1 groups. However, there was no significant difference in partial remission (OR\u2009=\u20091.10, 95% CI (0.87\u20131.39), <jats:inline-formula>\n                     <e:math xmlns:e=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M3\">\n                        <e:mi>P<\/e:mi>\n                        <e:mo>=<\/e:mo>\n                        <e:mn>0.42<\/e:mn>\n                     <\/e:math>\n                  <\/jats:inline-formula>) and seven adverse reactions (leukopenia, thrombocytopenia, nausea and vomiting, diarrhea, dermatitis, oral mucositis, and anemia) between the S-1 and non-S-1 groups. Additionally, statistical analyses with six subgroups were performed. S-1 was found to be a satisfactory chemotherapeutic agent combined with radiotherapy, intravenous chemotherapy, or chemoradiotherapy for NPC. As an oral medicine, the adverse reactions of S-1, especially gastrointestinal reactions, can be tolerated by patients, thereby optimizing their quality of life. S-1 may be a better choice for the treatment of NPC. This trial is registered with CRD42019122041.<\/jats:p>","DOI":"10.1155\/2021\/6690275","type":"journal-article","created":{"date-parts":[[2021,3,23]],"date-time":"2021-03-23T21:35:15Z","timestamp":1616535315000},"page":"1-15","source":"Crossref","is-referenced-by-count":5,"title":["Activity and Safety of Tegafur, Gimeracil, and Oteracil Potassium for Nasopharyngeal Carcinoma: A Systematic Review and Meta-Analysis"],"prefix":"10.1155","volume":"2021","author":[{"given":"Ximing","family":"Zhang","sequence":"first","affiliation":[{"name":"School of Basic Medical Sciences, Guangzhou Medical University, Guangzhou 511436, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiumei","family":"Tian","sequence":"additional","affiliation":[{"name":"Department of Biomedical Engineering, School of Basic Medical Sciences, Guangzhou Medical University, Guangzhou 511436, China"},{"name":"Affiliated Stomatology Hospital of Guangzhou Medical University, Guangzhou 511436, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5414-1376","authenticated-orcid":true,"given":"Yuezi","family":"Wei","sequence":"additional","affiliation":[{"name":"Department of Biomedical Engineering, School of Basic Medical Sciences, Guangzhou Medical University, Guangzhou 511436, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hao","family":"Deng","sequence":"additional","affiliation":[{"name":"Department of Preventive Medicine, School of Public Health, Guangzhou Medical University, Guangzhou 511436, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lichun","family":"Ma","sequence":"additional","affiliation":[{"name":"Department of Preventive Medicine, School of Public Health, Guangzhou Medical University, Guangzhou 511436, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ziyang","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Preventive Medicine, School of Public Health, Guangzhou Medical University, Guangzhou 511436, China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","reference":[{"key":"1","first-page":"425","article-title":"A study of TPS1 and TPF neoadjuvant chemotherapy on curative effect for treatment of patients with locally advanced nasopharyngeal carcinoma","volume":"7","author":"Y. Q. Han","year":"2017","journal-title":"Anti-Tumor Pharmacy"},{"key":"2","doi-asserted-by":"publisher","DOI":"10.1186\/s13014-019-1387-9"},{"key":"3","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejca.2015.08.006"},{"key":"4","doi-asserted-by":"publisher","DOI":"10.1016\/s1470-2045(15)70126-9"},{"key":"5","doi-asserted-by":"publisher","DOI":"10.1016\/j.radonc.2014.05.005"},{"key":"6","doi-asserted-by":"publisher","DOI":"10.3322\/caac.21338"},{"key":"7","doi-asserted-by":"publisher","DOI":"10.7314\/apjcp.2012.13.6.2495"},{"key":"8","first-page":"336","article-title":"Therapeutic effect of tegafur, gimeracil and oteracil capsule combined with celecoxib on patients with advanced gastric cancer","volume":"32","author":"W. Z. Kou","year":"2015","journal-title":"Journal of Xinxiang Medical University"},{"key":"9","doi-asserted-by":"publisher","DOI":"10.3892\/mco.2015.529"},{"key":"10","doi-asserted-by":"publisher","DOI":"10.3892\/ol_00000017"},{"key":"11","doi-asserted-by":"publisher","DOI":"10.1200\/jco.2009.26.2543"},{"key":"12","doi-asserted-by":"publisher","DOI":"10.1007\/s10120-010-0566-z"},{"key":"13","doi-asserted-by":"publisher","DOI":"10.1007\/s00280-008-0836-1"},{"key":"14","first-page":"2498","article-title":"A clinical observation of S-1 chemotherapy combined with radiotherapy for the treatment of advanced nasopharyngeal carcinoma","volume":"20","author":"H. L. Wu","year":"2012","journal-title":"Journal of Modern Oncology"},{"key":"15","first-page":"16","article-title":"Clinical observation of combination lobaplatin and S-1 concurrent chemoradiotherapy for treatment of loco-regionally advanced nasopharyngeal carcinoma","volume":"16","author":"M. Chen","year":"2016","journal-title":"World Latest Medicine Information"},{"key":"16","first-page":"107","article-title":"Efficacy and safety of S-1 in elderly patients with advanced nasopharyngeal carcinoma","volume":"16","author":"M. Q. Zhu","year":"2014","journal-title":"Chinese Journal of Medical Guide"},{"key":"17","first-page":"1823","article-title":"Effect of oral low-dose gimeracil and oteracil potassium capsules on advanced colorectal cancer giving up intravenous chemotherapy","volume":"19","author":"W. D. Fang","year":"2011","journal-title":"Journal of Modern Oncology"},{"key":"18","doi-asserted-by":"publisher","DOI":"10.1007\/s10637-018-00720-0"},{"key":"19","first-page":"443","article-title":"S-1 combined with concurrent radiotherapy for elderly patients with locally advanced nasopharyngeal carcinoma","volume":"19","author":"C. W. You","year":"2012","journal-title":"Chinese Journal of Clinical Oncology and Rehabilitation"},{"key":"20","doi-asserted-by":"publisher","DOI":"10.2147\/cmar.s234271"},{"key":"21","doi-asserted-by":"publisher","DOI":"10.1111\/cas.12657"},{"key":"22","first-page":"2852","article-title":"Comparison of radiotherapy respectively combined with docetaxel, cisplatin, or S-1 in the treatment of locally advanced nasopharyngeal carcinoma","volume":"27","author":"F. Xian","year":"2019","journal-title":"Journal of Modern Oncology"},{"key":"23","doi-asserted-by":"publisher","DOI":"10.2147\/cmar.s165804"},{"key":"24","doi-asserted-by":"publisher","DOI":"10.1515\/med-2017-0017"},{"volume-title":"Cochrane Handbook for Systematic Reviews of Interventions, Version 5.1.0","year":"2011","author":"J. Higgins","key":"25"},{"key":"26","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.b2535"},{"key":"27","first-page":"1825","article-title":"S-1 joint synchronization efficacy of radiation therapy for patients with locally advanced nasopharyngeal carcinoma","volume":"20","author":"Z. Y. Li","year":"2013","journal-title":"Chinese Journal of Cancer Prevention and Treatment"},{"key":"28","first-page":"40","article-title":"Comparative analyses of curative effect of SP and FP regimen chemotherapy in the treatment of advanced nasopharyngeal carcinoma","volume":"9","author":"Y. P. Cai","year":"2014","journal-title":"China Practical Medical"},{"key":"29","first-page":"532","article-title":"Curative effect of intensity-modulated radiotherapy combined with tegafur, gimeracil and oteracil potassium capsule for treatment of elderly patients with localized advanced nasopharyngeal carcinoma","volume":"34","author":"L. J. Chen","year":"2017","journal-title":"Journal of Xinxiang Medical University"},{"key":"30","article-title":"Effect of S-1 combined with docetaxel in the treatment of patients with advanced nasopharyngeal carcinoma","volume":"31","author":"H. Chen","year":"2018","journal-title":"Medical Equipment"},{"key":"31","first-page":"5329","article-title":"Effect observation of radical radiotherapy combined with S-1 and radical radiotherapy alone in the treatment of early nasopharyngeal carcinoma","volume":"26","author":"B. Y. He","year":"2015","journal-title":"Modern Diagnosis and Treatment"},{"key":"32","first-page":"264","article-title":"Recent curative effect and adverse reaction of S-1 and cisplatin concurrent chemoradiotherapy in the treatment of IMRT III and IV for stage a nasopharyngeal carcinoma","volume":"32","author":"N. X. Huang","year":"2019","journal-title":"Heilongjiang Medical Journal"},{"key":"33","article-title":"Effect of intensity modulated radiotherapy combined with S-1 on local advanced nasopharyngeal carcinoma in the elderly","volume":"238","author":"P. J. Liu","year":"2018","journal-title":"The Journal of Psychology"},{"key":"34","first-page":"72","article-title":"The short-term clinical efficacy and safety of docetaxel combined with cisplatin and S-1 in locally advanced nasopharynx cancer","volume":"9","author":"L. Liu","year":"2019","journal-title":"Anti-Tumor Pharmacy"},{"key":"35","first-page":"125","article-title":"Short-term efficacy and toxicity of S-1 combined with radical radiotherapy and radical radiotherapy for early nasopharyngeal carcinoma","volume":"18","author":"P. Mutaxi","year":"2014","journal-title":"World Latest Medicine Information"},{"key":"36","first-page":"39","article-title":"The short-terms effects and adverse reactions of IMRT chemotherapy with S-1 and cisplatin in the treatment of III, IV a phase nasopharyngeal cancer","volume":"697","author":"Q. Fan","year":"2019","journal-title":"Electronic Journal of Clinical Medical Literature"},{"key":"37","first-page":"2827","article-title":"Effect of S-1 concurrent chemoradiotherapy on locally advanced nasopharyngeal cancer","volume":"22","author":"Z. W. Wang","year":"2014","journal-title":"Journal of Modern Oncology"},{"key":"38","first-page":"175","article-title":"Application of S-1 in maintenance therapy after first-line treatment in patients with advanced nasopharyngeal carcinoma","volume":"28","author":"Y. Wang","year":"2018","journal-title":"Shenzhen Journal of Integrated Traditional Chinese and Western Medicine"},{"key":"39","first-page":"93","article-title":"Comparison of S-1 combined with radical radiation therapy and single radical radiation therapy in treatment of early nasopharyngeal carcinoma","volume":"33","author":"J. Yang","year":"2012","journal-title":"Journal of Kunming Medical College"},{"key":"40","first-page":"658","article-title":"Effect of tegafur combined with simultaneous integrated boost intensity modulated radiotherapy on local advanced nasopharyngeal carcinoma in the elderly and on immune function","volume":"25","author":"F. Yang","year":"2019","journal-title":"Geriatrics Health Care"},{"key":"41","first-page":"72","article-title":"Clinical observation of docetaxel combined with S-1 in the treatment of 3 cases in advanced nasopharyngeal carcinoma","volume":"25","author":"H. Q. Yu","year":"2016","journal-title":"Chinese Journal of Ethnomedicine and Ethnopharmacy"},{"key":"42","article-title":"The clinical effect of S-1 reverse intensity modulated radiotherapy on advanced nasopharyngeal carcinoma in the elderly","volume":"21","author":"Z. H. Zheng","year":"2015","journal-title":"Contemporary Medicine"},{"key":"43","article-title":"Clinical observation of nedaplatin combined with S-1 in the treatment of patients with distant metastatic nasopharyngeal carcinoma","volume":"10","author":"Y. Zou","year":"2015","journal-title":"Chinese Journal of Primary Medicine and Pharmacy"},{"key":"44","first-page":"1078","article-title":"The effect of S-1 combined with docetaxel in the treatment of patients with advanced chronic nasopharyngeal carcinoma","volume":"2007","author":"A. Y. Qin","year":"2019","journal-title":"Chronic Pathematology Journal"},{"key":"45","first-page":"95","volume-title":"Meta-analysis Software Application and Case Analysis","author":"M. H. Zheng","year":"2013","edition":"1st"}],"container-title":["Journal of Oncology"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/downloads.hindawi.com\/journals\/jo\/2021\/6690275.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/downloads.hindawi.com\/journals\/jo\/2021\/6690275.xml","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/downloads.hindawi.com\/journals\/jo\/2021\/6690275.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,3,23]],"date-time":"2021-03-23T21:35:39Z","timestamp":1616535339000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.hindawi.com\/journals\/jo\/2021\/6690275\/"}},"subtitle":[],"editor":[{"given":"Pierfrancesco","family":"Franco","sequence":"additional","affiliation":[],"role":[{"role":"editor","vocabulary":"crossref"}]}],"short-title":[],"issued":{"date-parts":[[2021,3,23]]},"references-count":45,"alternative-id":["6690275","6690275"],"URL":"https:\/\/doi.org\/10.1155\/2021\/6690275","relation":{},"ISSN":["1687-8469","1687-8450"],"issn-type":[{"type":"electronic","value":"1687-8469"},{"type":"print","value":"1687-8450"}],"subject":[],"published":{"date-parts":[[2021,3,23]]}}}