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Chronic prostatitis\/chronic pelvic pain syndrome (CP\/CPPS) is one of the most common diseases in urology, but its pathogenesis remains unclear. As a kind of chronic pain which the patients suffered for more than 3 months, we investigated the influence on patients\u2019 brain functional connectivity in resting state. Methods. We recruited a cohort of 18 right-handed male patients with CP\/CPPS and 21 healthy male right-handed age-matched controls. Their resting-state fMRI data and structural MRI data were preprocessed and processed by RESTPlus V1.22. To assess the integrity of the default mode network (DMN), we utilized the voxel-wised analysis that we set medial prefrontal cortex (mPFC) and posterior cingulate gyrus (PCC) as seed points to compare the global functional connectivity (FC) strength. Results. Compared with healthy control, the FC strength between left mPFC and posterior DMN decreased in the group of CP\/CPPS (<jats:inline-formula>\n                     <a:math xmlns:a=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M1\">\n                        <a:mi>P<\/a:mi>\n                        <a:mo>&lt;<\/a:mo>\n                        <a:mn>0.05<\/a:mn>\n                     <\/a:math>\n                  <\/jats:inline-formula>, GFR correction, voxel <jats:inline-formula>\n                     <c:math xmlns:c=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M2\">\n                        <c:mi>P<\/c:mi>\n                        <c:mo>&lt;<\/c:mo>\n                        <c:mn>0.01<\/c:mn>\n                     <\/c:math>\n                  <\/jats:inline-formula>, cluster <jats:inline-formula>\n                     <e:math xmlns:e=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M3\">\n                        <e:mi>P<\/e:mi>\n                        <e:mo>&lt;<\/e:mo>\n                        <e:mn>0.05<\/e:mn>\n                     <\/e:math>\n                  <\/jats:inline-formula>), and the FC strength between the left anterior cerebellar lobe and posterior DMN increased (<jats:inline-formula>\n                     <g:math xmlns:g=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M4\">\n                        <g:mi>P<\/g:mi>\n                        <g:mo>&lt;<\/g:mo>\n                        <g:mn>0.05<\/g:mn>\n                     <\/g:math>\n                  <\/jats:inline-formula>, GFR correction, voxel <jats:inline-formula>\n                     <i:math xmlns:i=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M5\">\n                        <i:mi>P<\/i:mi>\n                        <i:mo>&lt;<\/i:mo>\n                        <i:mn>0.01<\/i:mn>\n                     <\/i:math>\n                  <\/jats:inline-formula>, cluster <jats:inline-formula>\n                     <k:math xmlns:k=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M6\">\n                        <k:mi>P<\/k:mi>\n                        <k:mo>&lt;<\/k:mo>\n                        <k:mn>0.05<\/k:mn>\n                     <\/k:math>\n                  <\/jats:inline-formula>). In the patient group, there was a positive correlation between the increased FC strength and the score of the Hospital Anxiety and Depression Scale (HADS) anxiety subscale (<jats:inline-formula>\n                     <m:math xmlns:m=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M7\">\n                        <m:mi>r<\/m:mi>\n                        <m:mo>=<\/m:mo>\n                        <m:mn>0.5509<\/m:mn>\n                     <\/m:math>\n                  <\/jats:inline-formula>, <jats:inline-formula>\n                     <o:math xmlns:o=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M8\">\n                        <o:mi>P<\/o:mi>\n                        <o:mo>=<\/o:mo>\n                        <o:mn>0.0178<\/o:mn>\n                     <\/o:math>\n                  <\/jats:inline-formula>) in the left anterior cerebellar lobe, a negative correlation between the decreased FC strength and the score of the National Institutes of Health Chronic Prostatitis Symptom Index (<jats:inline-formula>\n                     <q:math xmlns:q=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M9\">\n                        <q:mi>r<\/q:mi>\n                        <q:mo>=<\/q:mo>\n                        <q:mo>\u2212<\/q:mo>\n                        <q:mn>0.6281<\/q:mn>\n                     <\/q:math>\n                  <\/jats:inline-formula>, <jats:inline-formula>\n                     <s:math xmlns:s=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M10\">\n                        <s:mi>P<\/s:mi>\n                        <s:mo>=<\/s:mo>\n                        <s:mn>0.0053<\/s:mn>\n                     <\/s:math>\n                  <\/jats:inline-formula>) in the area of left mPFC, and a negative correlation between the decreased FC strength and the score of HADS anxiety subscale (<jats:inline-formula>\n                     <u:math xmlns:u=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M11\">\n                        <u:mi>r<\/u:mi>\n                        <u:mo>=<\/u:mo>\n                        <u:mo>\u2212<\/u:mo>\n                        <u:mn>0.5252<\/u:mn>\n                     <\/u:math>\n                  <\/jats:inline-formula>, <jats:inline-formula>\n                     <w:math xmlns:w=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M12\">\n                        <w:mi>P<\/w:mi>\n                        <w:mo>=<\/w:mo>\n                        <w:mn>0.0252<\/w:mn>\n                     <\/w:math>\n                  <\/jats:inline-formula>). Conclusion. Patients with CP\/CPPS had alterations in brain function, which consisted of the default mode network\u2019s compromised integrity. These alterations might play a crucial role in the pathogenesis and development of CP\/CPPS.<\/jats:p>","DOI":"10.1155\/2021\/6690414","type":"journal-article","created":{"date-parts":[[2021,5,7]],"date-time":"2021-05-07T22:17:22Z","timestamp":1620425842000},"page":"1-9","source":"Crossref","is-referenced-by-count":11,"title":["Potential Alterations of Functional Connectivity Analysis in the Patients with Chronic Prostatitis\/Chronic Pelvic Pain Syndrome"],"prefix":"10.1155","volume":"2021","author":[{"given":"Shengyang","family":"Ge","sequence":"first","affiliation":[{"name":"Department of Urology, Huashan Hospital, Fudan University, 12 Central Urumqi Rd, Shanghai 200040, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Qingfeng","family":"Hu","sequence":"additional","affiliation":[{"name":"Department of Urology, Huashan Hospital, Fudan University, 12 Central Urumqi Rd, Shanghai 200040, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yijun","family":"Guo","sequence":"additional","affiliation":[{"name":"Department of Urology, Jing\u2019an District Center Hospital of Shanghai, 259 Xikang Rd, Shanghai 200040, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ke","family":"Xu","sequence":"additional","affiliation":[{"name":"Department of Urology, Huashan Hospital, Fudan University, 12 Central Urumqi Rd, Shanghai 200040, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1257-3100","authenticated-orcid":true,"given":"Guowei","family":"Xia","sequence":"additional","affiliation":[{"name":"Department of Urology, Huashan Hospital, Fudan University, 12 Central Urumqi Rd, Shanghai 200040, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4291-8920","authenticated-orcid":true,"given":"Chuanyu","family":"Sun","sequence":"additional","affiliation":[{"name":"Department of Urology, Huashan Hospital, Fudan University, 12 Central Urumqi Rd, Shanghai 200040, China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","reference":[{"issue":"5","key":"1","first-page":"258","article-title":"The 2001 Giessen Cohort Study on patients with prostatitis syndrome--an evaluation of inflammatory status and search for microorganisms 10 years after a first analysis","volume":"35","author":"H. 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