{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,5,14]],"date-time":"2025-05-14T02:43:29Z","timestamp":1747190609179,"version":"3.40.5"},"reference-count":54,"publisher":"Wiley","license":[{"start":{"date-parts":[[2021,4,17]],"date-time":"2021-04-17T00:00:00Z","timestamp":1618617600000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Hubei University of Chinese Medicine","award":["3001\u201350150","B2020093","2020BCB015ss"],"award-info":[{"award-number":["3001\u201350150","B2020093","2020BCB015ss"]}]},{"name":"Research Project of the Education Department of Hubei province","award":["3001\u201350150","B2020093","2020BCB015ss"],"award-info":[{"award-number":["3001\u201350150","B2020093","2020BCB015ss"]}]},{"name":"Hubei Provincial Scientific and Research Department","award":["3001\u201350150","B2020093","2020BCB015ss"],"award-info":[{"award-number":["3001\u201350150","B2020093","2020BCB015ss"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Evidence-Based Complementary and Alternative Medicine"],"published-print":{"date-parts":[[2021,4,17]]},"abstract":"<jats:p>Chronic gastritis (CG) places a considerable burden on the healthcare system worldwide. Traditional Chinese Medicine (TCM) formulas characterized by multicompounds and multitargets have been acknowledged with striking effects in the treatment of CG in China\u2019s history. Nevertheless, their accurate mechanisms of action are still ambiguous. In this study, we analyzed the effective compounds, potential targets, and related biological pathway of Lianpu Drink (LPD), a TCM formula which has been reported to have a therapeutic effect on CG, by contrasting a \u201ccompound-target-disease\u201d network. According to the results, 92 compounds and 5762 putative targets of LPD were screened; among them, 8 compounds derived from different herbs in LPD and 30 common targets related to LPD and CG were selected as candidate compounds and precision targets, respectively. Meanwhile, the predicted common targets were verified by Kyoto Encyclopedia of Genes and Genomes (KEGG) signaling pathway analysis and pharmacological experiments. The results demonstrated that quercetin, ephedrine, trigonelline, crocetin, and \u03b2-sitosterol were major effective compounds of LPD responsible for the CG treatment by inhibiting the activation of the JAK 2-STAT 3 signaling pathway to reduce the expressions of cyclin D1 and Bcl-2 proteins. The study provides evidence for the mechanism of understanding of LPD for the treatment of CG.<\/jats:p>","DOI":"10.1155\/2021\/6693472","type":"journal-article","created":{"date-parts":[[2021,4,19]],"date-time":"2021-04-19T22:33:06Z","timestamp":1618871586000},"page":"1-13","source":"Crossref","is-referenced-by-count":2,"title":["Study on the Mechanism of Lianpu Drink for the Treatment of Chronic Gastritis Based on Network Pharmacology"],"prefix":"10.1155","volume":"2021","author":[{"given":"Shuhan","family":"Zhou","sequence":"first","affiliation":[{"name":"Clinical College, Hubei University of Chinese Medicine, Wuhan 430000, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yanjun","family":"Duan","sequence":"additional","affiliation":[{"name":"College of Basic Medicine, Hubei University of Chinese Medicine, Wuhan 430000, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yu","family":"Deng","sequence":"additional","affiliation":[{"name":"Clinical College, Hubei University of Chinese Medicine, Wuhan 430000, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Miao","family":"Wang","sequence":"additional","affiliation":[{"name":"Clinical College, Hubei University of Chinese Medicine, Wuhan 430000, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chaoqun","family":"Huang","sequence":"additional","affiliation":[{"name":"Clinical College, Hubei University of Chinese Medicine, Wuhan 430000, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zhiyi","family":"Liu","sequence":"additional","affiliation":[{"name":"Clinical College, Hubei University of Chinese Medicine, Wuhan 430000, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiaohui","family":"Xu","sequence":"additional","affiliation":[{"name":"Clinical College, Hubei University of Chinese Medicine, Wuhan 430000, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1107-6372","authenticated-orcid":true,"given":"Wenliang","family":"Lv","sequence":"additional","affiliation":[{"name":"Clinical College, Hubei University of Chinese Medicine, Wuhan 430000, China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","reference":[{"key":"1","first-page":"504","article-title":"Chronic gastritis: a clinico-pathological classification","volume":"83","author":"P. 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Liu","year":"2012","journal-title":"China Journal of Chinese Medicine"},{"issue":"6","key":"14","first-page":"867","article-title":"Efficacy of Banxia Xiexin decoction in a rat model of chronic atrophic gastritis","volume":"39","author":"Y. Bai","year":"2019","journal-title":"Journal of Traditional Chinese Medicine = Chung I Tsa Chih Ying Wen pan"},{"key":"15","first-page":"76","article-title":"Proteomic analysis of gastric mucosa in chronic gastritis rats of Pi-Wei damp-heat syndrome treated by Sanren decoction: an experimental study","volume":"33","author":"S. Y. Liao","year":"2013","journal-title":"Zhongguo Zhong Xi Yi Jie He Za Zhi"},{"key":"16","doi-asserted-by":"publisher","DOI":"10.1002\/cjoc.201800156"},{"key":"17","doi-asserted-by":"publisher","DOI":"10.1016\/j.phymed.2018.09.228"},{"key":"18","first-page":"930","article-title":"Virtual evaluation on anti-inflammatory activity of iridoids from cape jasmine fruit and adhesive rehmannia root","volume":"40","author":"J. Xing","year":"2009","journal-title":"Chinese Traditional and Herbal Drugs"},{"key":"19","first-page":"99","article-title":"Clinical effect of particles of Houpu Sijunzi decoction in the treatment of chronic gastritis","volume":"11","author":"X. Q. Yang","year":"2014","journal-title":"China Medical Herald"},{"key":"20","first-page":"26","article-title":"Clinical study on Pinellia heart-draining decoction for treating chronic atrophic gastritis","volume":"35","author":"S. Y. Li","year":"2015","journal-title":"Henan Traditional Chinese Medicine"},{"volume-title":"Mengying Wang Medical Book","year":"1999","author":"Z. X. Sheng","key":"21"},{"key":"22","first-page":"1792","article-title":"Summary of clinical application of coptis and officinal Magnolia bark beverage","volume":"39","author":"M. 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