{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,26]],"date-time":"2026-10-26T13:52:43Z","timestamp":1793022763050,"version":"4.5.0"},"reference-count":40,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2021,3,5]],"date-time":"2021-03-05T00:00:00Z","timestamp":1614902400000},"content-version":"vor","delay-in-days":63,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Military Medical Science and Technology Youth Training Program","award":["18QNP022"],"award-info":[{"award-number":["18QNP022"]}]},{"name":"Military Medical Science and Technology Youth Training Program","award":["TC201903"],"award-info":[{"award-number":["TC201903"]}]},{"name":"Tangdu Hospital","award":["18QNP022"],"award-info":[{"award-number":["18QNP022"]}]},{"name":"Tangdu Hospital","award":["TC201903"],"award-info":[{"award-number":["TC201903"]}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["BioMed Research International"],"published-print":{"date-parts":[[2021,1]]},"abstract":"<jats:p><jats:italic>Background<\/jats:italic>. Longbone infected bone defect remains a great challenge due to multiple surgeries, long\u2010term treatment duration, and uncertain prognosis. Treatment principles include eradication\/debridement, stabilization, and antibiotic administration. An antibiotic cement\u2010coated nail has shown great prospects due to both local antibiotic elution and stabilization of bone defects. However, the current fabrication technique remains to be improved. <jats:italic>Methods<\/jats:italic>. For the first time, we described a new method for custom\u2010made cement\u2010coated nail fabrication based on a 3D printing technique. A retrospective study of 19 consecutive patients with long bone infected bone defects from one medical center was conducted who met the inclusion and exclusion criteria from November 2016 to May 2020. The treatment involved thorough debridement, custom\u2010made antibiotic cement\u2010coated nail filling, and culture\u2010specific systemic antibiotic treatment guided by a multidisciplinary team. Clinical and radiographic examinations (X\u2010ray and CT scans) were used to evaluate bony union. Clinical and laboratory examinations were used to evaluate the infection control. The SF\u201036 score was used to evaluate patients\u2019 quality of life pre\u2010 and postoperatively. <jats:italic>Results<\/jats:italic>. The mean follow\u2010up was 98.8 weeks (ranging from 40 to 192). All cases achieved infection control, 3 cases achieved bone healing after one\u2010stage operation, and 12 cases achieved bone healing after a two\u2010stage bone graft procedure. At the last follow\u2010up, none of the 19 patients had infection recurrence or 1 case had failure of the protective plate. The pre\u2010 and postoperative SF\u201036 score showed that there were statistical differences in all the 9 aspects. <jats:italic>Conclusions<\/jats:italic>. The precise custom\u2010made antibiotic cement\u2010coated intramedullary nail through the 3D printing technique used in this study is an effective strategy for the treatment of infected bone defects of long bone. This technique may help to increase the infection control rate and promote bone healing.<\/jats:p>","DOI":"10.1155\/2021\/6693906","type":"journal-article","created":{"date-parts":[[2021,3,6]],"date-time":"2021-03-06T02:20:34Z","timestamp":1614997234000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":14,"title":["Custom\u2010Made Antibiotic Cement\u2010Coated Nail for the Treatment of Infected Bone Defect"],"prefix":"10.1155","volume":"2021","author":[{"given":"Guoliang","family":"Wang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wen","family":"Luo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yong","family":"Zhou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhenfeng","family":"Zhu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zihou","family":"Zhao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shiyu","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jing","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xuebin","family":"Feng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yao","family":"Zheng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiahe","family":"Liang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiangpu","family":"Yi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5826-0070","authenticated-orcid":false,"given":"Yong","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7930-5189","authenticated-orcid":false,"given":"Yunfei","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2021,3,5]]},"reference":[{"key":"e_1_2_11_1_2","first-page":"176","article-title":"The infected nonunion of the tibia","volume":"315","author":"Toh C.-L.","year":"1995","journal-title":"Clinical Orthopaedics and Related Research"},{"key":"e_1_2_11_2_2","doi-asserted-by":"publisher","DOI":"10.5435\/00124635-200510000-00006"},{"key":"e_1_2_11_3_2","first-page":"259","article-title":"Approach to adult osteomyelitis","volume":"16","author":"Cierny G.","year":"1987","journal-title":"Orthopaedic Review"},{"key":"e_1_2_11_4_2","doi-asserted-by":"publisher","DOI":"10.1097\/00003086-198611000-00020"},{"key":"e_1_2_11_5_2","doi-asserted-by":"publisher","DOI":"10.1097\/BCO.0b013e318230efcf"},{"key":"e_1_2_11_6_2","doi-asserted-by":"publisher","DOI":"10.1097\/BOT.0b013e31803ea9e6"},{"key":"e_1_2_11_7_2","doi-asserted-by":"publisher","DOI":"10.1097\/01.blo.0000143741.92384.18"},{"key":"e_1_2_11_8_2","first-page":"387","article-title":"Management of adult osteomyelitis","volume":"75","author":"Colyer R. 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